Anti-Atopic Effects of Mixed Extracts from Date Plum, Persimmon, and Mulberry Leaves

Cho, Byoung Ok; Yin, Hong; Shin, Jae Young; Fang, Chong Zhou; Chang, Che Denis; Jang, Seon Il

doi:10.3746/jkfn.2016.45.4.501

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…These results suggest that metabolite of strain K-07 can ameliorate skin barrier and anti-inflammatory effects. In addition, anti-atopic effects of mixed extracts from date plum, persimmon, and mulberry leaves (DPME) have been suggested from the perspective of natural anti-inflammatory ingredients [ 27 ]. DPME can reduce the production of pro-inflammatory mediators (NO, TNF-α, and IL-6) in LPS-stimulated RAW264.7 macrophages.…”

Section: Discussionmentioning

confidence: 99%

Fermented Angelicae tenussimae with Aspergillus oryzae Improves Skin Barrier Properties, Moisturizing, and Anti-Inflammatory Responses

Sohn

Kim

et al. 2022

IJMS

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Angelicae tenussimae root has been used as a traditional medicine in Asia. Recently, anti-melanogenic and anti-photogenic effects of fermented A. tenuissima root (FAT) were identified. However, information about the anti-atopic dermatitis action of FAT is limited. Thus, the purpose of this study is to determine the applicability of FAT to AD by identifying the efficacy of FAT on the skin barrier and inflammatory response, which are the main pathogenesis of AD. Expression levels of skin barrier components and the production of inflammatory mediators in human keratinocyte and mouse macrophage cells were measured by quantitative RT-PCR or ELISA. FAT upregulated the expression of skin barrier components (filaggrin, involucrin, loricurin, SPTLC1) and inhibited the secretion of an inflammatory chemokine TARC in HaCaT cells. Furthermore, it suppressed pro-inflammatory cytokines (IL-6, TNF-α) and nitric oxide production in LPS-induced RAW264.7 cells. In addition, ligustilide increased filaggrin and SPTLC1, and also lowered pro-inflammatory mediators that increased in atopic environments, such as in FAT results. This means that ligustilide, one of the active ingredients derived from FAT, can ameliorate AD, at least in part, by promoting skin barrier formation and downregulating inflammatory mediators. These results suggest that FAT is a potential functional cosmetic material for the care and management of AD.

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Section: Discussionmentioning

confidence: 99%

Fermented Angelicae tenussimae with Aspergillus oryzae Improves Skin Barrier Properties, Moisturizing, and Anti-Inflammatory Responses

Sohn

Kim

et al. 2022

IJMS

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Studies on the Cellular Physiological Activity of Lonicera japonica·Glycyrrhiza uralensis·Lentinula edodes Complex Extracts

Choi¹,

Choi²,

Seo³

2021

J Korean Soc Cosmetol

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With ultraviolet rays, pollution and external stimuli acting as oxidation stress on the skin in line with recent changes in the global environment, modern people are increasingly relying on the frequency and dependence of cosmetics with certain effects. In particular, the characteristics of the skin of the elderly are that inflammation tends to occur due to the deterioration of the barrier function of the skin. To minimize this, research and development of cosmetics using natural materials that do not stimulate the skin and have effective effects are continuously increasing. The purpose of this study was to analyze the physiological activity of the Lonicera japonica•Glycyrrhiza uralensis FISCH•Lentinula edodes (LGL) complex extracts to confirm its potential as a cosmetic material. Our method are cytotoxicity test of LGL complex extracts in the HaCaT and RAW264.7 cells. RAW 264.7 The effects of cell protection from inflammation were measure in cells to identify anti-inflammatory effects. Also, to identify antioxidant effects, DPPH radical scavenging activity test and analysis of the total phenol and total flavonoid contents., tyrosinase inhibitory activity, elastase inhibitory activity, measured cell survival rate by UV-B irradiation in HaCaT. The results of this study are as follows. In the cytotoxicity test, the LGL complex extracts showed stable cell viability. RAW 264.7 cells treated with the LGL complex extracts showed a superior concentration-dependent inhibitory effects on Nitric oxide (NO) synthesis than cells treated with Lipopolysaccharide (LPS). In the DPPH radical scavenging activity test, the LGL complex extracts showed a high scavenging activity at 200 μg/mL of 50% EtOH. In the anti-inflammatory test. Moreover, the results of the analysis on the antioxidant activity of the LGL complex extracts confirmed the phenolic and flavonoid contents. In addition, when UV-B was run on HaCaT cells and absorbance was measured, the cell protection effect was shown to increase dependent on concentrations in the LGL complex extracts DW and 50% EtOH extracts. The tyrosinase inhibitory activity was found to increase concentration-dependent activity in 50% EtOH and 100% EtOH extracts of LGL complex extracts, indicating that active inhibition was more effective than positive control arbutin. Elastase inhibitory activity is shown to increase concentration-dependent at LGL complex extracts DW, 50% EtOH. Based on these results, the LGL complex extracts were found to have excellent cellular physiological activity. Accordingly, basic data on the development of functional cosmetics are provided and systematic and continuous research on the safety of natural products is required.

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Anti-Atopic Effects of Mixed Extracts from Date Plum, Persimmon, and Mulberry Leaves

Cited by 2 publications

References 33 publications

Fermented Angelicae tenussimae with Aspergillus oryzae Improves Skin Barrier Properties, Moisturizing, and Anti-Inflammatory Responses

Fermented Angelicae tenussimae with Aspergillus oryzae Improves Skin Barrier Properties, Moisturizing, and Anti-Inflammatory Responses

Studies on the Cellular Physiological Activity of Lonicera japonica·Glycyrrhiza uralensis·Lentinula edodes Complex Extracts

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