Anti‐atopic dermatitis effects of hydrolyzed celery extract in mice

Nchang, Denis; Cho, Byoung Ok; Shin, Jae Young; Kang, Hyun Ju; Kim, Ji-su; Choi, Jiwon; Jang, Seon Il

doi:10.1111/jfbc.13198

Cited by 11 publications

(12 citation statements)

References 38 publications

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“…Although the exact mechanisms are not clear, it is possible that the apigenin-induced FLG upregulation could result from its antioxidant properties [ 206 ]. A more recent study in a mice model of AD revealed that both apigenin and other biologically active compounds present in celery, apigetrin and luteolin have ameliorative effects on AD signs and symptoms [ 207 ]. Additionally, apigenin has been suggested to be a promising agent for itch-reducing therapy, through its modulation of the IL-31 cytokine [ 208 ].…”

Section: Acquired Flg Deficiency–regulation Of Flg Expressionmentioning

confidence: 99%

New Treatments for Atopic Dermatitis Targeting Skin Barrier Repair via the Regulation of FLG Expression

Dębińska

2021

JCM

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Atopic dermatitis (AD) is one of the most common chronic, inflammatory skin disorders with a complex etiology and a broad spectrum of clinical phenotypes. Despite its high prevalence and effect on the quality of life, safe and effective systemic therapies approved for long-term management of AD are limited. A better understanding of the pathogenesis of atopic dermatitis in recent years has contributed to the development of new therapeutic approaches that target specific pathophysiological pathways. Skin barrier dysfunction and immunological abnormalities are critical in the pathogenesis of AD. Recently, the importance of the downregulation of epidermal differentiation complex (EDC) molecules caused by external and internal stimuli has been extensively emphasized. The purpose of this review is to discuss the innovations in the therapy of atopic dermatitis, including biologics, small molecule therapies, and other drugs by highlighting regulatory mechanisms of skin barrier-related molecules, such as filaggrin (FLG) as a crucial pathway implicated in AD pathogenesis.

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Section: Acquired Flg Deficiency–regulation Of Flg Expressionmentioning

confidence: 99%

New Treatments for Atopic Dermatitis Targeting Skin Barrier Repair via the Regulation of FLG Expression

Dębińska

2021

JCM

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“…A previous study reported that CA‐treated wheat germ extract enhanced the anti‐inflammatory activity of wheat germ (Jeong et al., 2017). Hydrochloric acid‐hydrolyzed celery extract was shown to have improved anti‐inflammatory activities and ameliorated atopic dermatitis‐like symptoms in primary splenocytes and mice (Che et al., 2020; Shin et al., 2019). Several enzymes have been employed for the extraction of targeted bioactive flavonoids from plants including citrus peels, grapes, and apples (Gómez‐García et al., 2012; Li et al., 2006; Zheng et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Citric acid and enzyme‐assisted modification of flavonoids from celery ( Apium graveolens ) extract and their anti‐inflammatory activity in HMC‐1.2 cells

et al. 2021

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Apium graveolens (celery) of the family Apiaceae contains bioactive compounds including luteolin and apigenin. The purpose of this study was to increase the extraction yield of apigenin and luteolin in celery extract using green technology and to evaluate their biological activities. The results showed that CA and β‐glucosidase‐assisted celery extraction transformed apiin in the celery to apigenin with an increase in luteolin concentration. The CA and β‐glucosidase‐treated celery extract (CAGE) improved the anti‐inflammatory properties of celery extract by inhibiting the expression and production of inflammatory cytokines (IL‐6, IL‐8, IL‐31, and TNF‐α) in IL‐33‐stimulated mast cells (HMC‐1.2 cells). Their mechanism of action was tied to the inhibition of ERK, JNK, IKKα, IκBα, and NF‐κB activation by CAGE in the stimulated cells. In conclusion, CA and enzyme treatment can be considered as a useful biotechnology tool for the improvement of bioactive compounds in celery and hence improve on their bioactivity. Practical applications Apium graveolens commonly called celery is an edible agricultural product cultivated throughout the world and known as a “superfood.” Celery contains bioactive compounds including apigenin and luteolin that contribute to their described biological activities. However, extracting celery using normal extraction procedures such as hot water and ethanol methods yields only a small amount of apigenin and luteolin. In the present study, we introduced an eco‐friendly method using citric and β‐glucosidase to obtain apigenin and luteolin‐rich celery extract with improved anti‐inflammatory activities. The present work will spark studies on the conversion of less biologically active compounds in functional food materials to more active compounds using CA and β‐glucosidase, and the development of functional food with specifically enriched bioactive substances at the industrial levels.

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“…The key flavonoid in celery has been identified as apigenin, which is present in aglycone and glycoside forms such as apiin (apigenin-7-apioglucoside) and apigetrin (apigenin-7-glucoside). Compared to its glycosides, apigenin has been reported to have more potent bioactivity in the form of stronger anti-inflammatory [2] and antioxidant [3] properties. Apigenin has also independently garnered interest due to its wide range of pharmacological benefits including anti-carcinogenic and anti-toxicant effects [4].…”

Section: Introductionmentioning

confidence: 99%

Optimisation of an Aglycone-Enhanced Celery Extract with Germinated Soy Supplementation Using Response Surface Methodology

Lau

Koh

Dayal

et al. 2021

Foods

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In this study, the extraction conditions of bioactive aglycones from a celery extract supplemented with germinated soy were optimised by a response surface methodology. For subsequent enzymatic hydrolysis to enhance the apigenin content, increased production of its precursor apigetrin was firstly achieved through acidic extraction at optimal conditions, involving water at pH 1, at 75 °C for 2 h. Subsequently, a central composite design was conducted to analyse the pH (3–11) and temperature (25–35 °C) effects on the aglycone levels (apigenin, daidzein and genistein). The optimal extraction conditions were pH 7.02 and 29.99 °C, which resulted in a 40-fold increase in apigenin. The novel and cost-effective application of germinated soy β-glucosidase for the conversion of aglycones in non-soy foods is demonstrated. The enhanced bioactivities of aglycones may suggest potential applications for similar formulations as functional food ingredients.

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Anti‐atopic dermatitis effects of hydrolyzed celery extract in mice

Cited by 11 publications

References 38 publications

New Treatments for Atopic Dermatitis Targeting Skin Barrier Repair via the Regulation of FLG Expression

New Treatments for Atopic Dermatitis Targeting Skin Barrier Repair via the Regulation of FLG Expression

Citric acid and enzyme‐assisted modification of flavonoids from celery ( Apium graveolens ) extract and their anti‐inflammatory activity in HMC‐1.2 cells

Optimisation of an Aglycone-Enhanced Celery Extract with Germinated Soy Supplementation Using Response Surface Methodology

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