Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE−/− mice through modulation of proinflammatory cytokines and oxidative stress

Lactobacillus plantarum improves LPS-induced Caco2 cell line intestinal barrier damage via cyclic AMP-PKA signaling

“…Silencing experiments confirmed that the protective effect of LP may be realized through inhibition of MAPK and NFκB pathways [ 36 ]. A number of experiments have also shown that LP reduces inflammation and increase tight junction protein expression to protect host cells by inhibiting the NFκB pathway [ 37 – 41 ]. Studies have shown that lactobacillus inhibits the upregulation of IL-6 and CXCL8 through TLR negative regulators (A20, Tollip, SIGIRR, and IRAKM), P38 MAPK and P65 NF-κB signaling pathways, thus playing a protective role in regulating immunity [ 42 , 43 ].…”

Dosage of Dual-Protein Nutrition Differentially Impacts the Formation of Atherosclerosis in ApoE−/− Mice

“…Then, the mixture of PCR products was purified with Gene JET Gel Extraction Kit (Thermo Scientific Inc., Waltham, MA, USA). Sequencing libraries were generated using NEB Next Ultra DNA Library Prep Kit for Illumina (NEB Inc., Beijing, China) following the manufacturer's recommendations, and the library quality was assessed on the Qubit 2.0 Fluorometer (Thermo Scientific Inc., Waltham, MA, USA) and Agilent Bioanalyzer 2100 system [22]. The library was sequenced on an Illumina MiSeq platform and 250/300 bp paired-end reads were generated.…”

Potential Benefits of Probiotics and Prebiotics for Coronary Heart Disease and Stroke

“…Supplementation of probiotic L. mucosae A1 exhibited effectiveness in the treatment of hyperlipidemia and atherosclerosis and improved gut microbiota dysbiosis, including increased richness and diversity in ApoE -/- mice on a Western diet [ 91 ]. The anti-atherosclerotic effects of L. plantarum ATCC 14917 were also observed in ApoE -/- mice via modulation of proinflammatory cytokines TNFα and IL1-β, oxidative stress, and gut microbiota [ 92 ]. Administration of this probiotic strain increased the proportion of Bacteroidetes , whereas it attenuated the abundance of Firmicutes , Verrucomicrobia, and Proteobacteria .…”