Anti-atherosclerosis of oligomeric proanthocyanidins from Rhodiola rosea on rat model via hypolipemic, antioxidant, anti-inflammatory activities together with regulation of endothelial function

Zhou, Qian; Han, Xue; Li, Rongbin; Zhao, Wen; Bai, Bingyao; Yan, Chenjing; Dong, Xinhua

doi:10.1016/j.phymed.2018.10.002

Cited by 43 publications

(37 citation statements)

References 73 publications

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“…Within the IL1B promoter region in question, we found the only unannotated SNP (rs549858786), which can reduce the expression of this gene (Table 5). As for our keyword search in PubMed [38], it resulted in a pharmaceutical original research article [135] on IL1B deficiency as a physiological marker of successful treatment of atherosclerosis using oligomeric proanthocyanidins from Rhodiola rosea, as detailed in Table 5. This time, we surprisingly found an article [136] on proinflammatory effects of cigarette smoke condensates as an atherogenic risk factor, suggesting that passive smoking can be as dangerous as active one.…”

Section: Human Genes Associated With Obesitymentioning

confidence: 99%

Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It

Пономаренко

Рассказов

Chadaeva

et al. 2020

IJMS

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(1) Background: The World Health Organization (WHO) regards atherosclerosis-related myocardial infarction and stroke as the main causes of death in humans. Susceptibility to atherogenesis-associated diseases is caused by single-nucleotide polymorphisms (SNPs). (2) Methods: Using our previously developed public web-service SNP_TATA_Comparator, we estimated statistical significance of the SNP-caused alterations in TATA-binding protein (TBP) binding affinity for 70 bp proximal promoter regions of the human genes clinically associated with diseases syntonic or dystonic with atherogenesis. Additionally, we did the same for several genes related to the maintenance of mitochondrial genome integrity, according to present-day active research aimed at retarding atherogenesis. (3) Results: In dbSNP, we found 1186 SNPs altering such affinity to the same extent as clinical SNP markers do (as estimated). Particularly, clinical SNP marker rs2276109 can prevent autoimmune diseases via reduced TBP affinity for the human MMP12 gene promoter and therefore macrophage elastase deficiency, which is a well-known physiological marker of accelerated atherogenesis that could be retarded nutritionally using dairy fermented by lactobacilli. (4) Conclusions: Our results uncovered SNPs near clinical SNP markers as the basis of neutral drift accelerating atherogenesis and SNPs of genes encoding proteins related to mitochondrial genome integrity and microRNA genes associated with instability of the atherosclerotic plaque as a basis of directional natural selection slowing atherogenesis. Their sum may be stabilizing the natural selection that sets the normal level of atherogenesis.

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Section: Human Genes Associated With Obesitymentioning

confidence: 99%

Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It

Пономаренко

Рассказов

Chadaeva

et al. 2020

IJMS

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“…Our lab has, for the first time, successfully purified six compounds (catechin, epicatechin, procyanidin B7, procyanidin B6, procyanidin B3 and procyanidin B1) from proanthocyanidins, with high speed counter-current chromatography. So far, proanthocyanidins have been shown to possess multiple biological functions, such as anti-oxidation, anti-inflammation, anti-tumor, anti-bacteria, sleep improvement, anti-hyperglycemia and lowering blood lipids [23][24][25]. However, there are few reports about the effects of proanthocyanidins in lipid metabolism dysregulation in T2DM, and the mechanism is far from being illustrated.…”

Section: Introductionmentioning

confidence: 99%

Proanthocyanidins Ameliorated Deficits of Lipid Metabolism in Type 2 Diabetes Mellitus Via Inhibiting Adipogenesis and Improving Mitochondrial Function

Tie

Wang

Liang

et al. 2020

IJMS

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Proanthocyanidins are the major active compounds extracted from Iris lactea Pall. var. Chinensis (Fisch.) Koidz (I. lactea). Proanthocyanidins exhibit a variety of pharmacological activities such as anti-oxidation, anti-inflammation, anti-tumor, and lowering blood lipids. However, the underlying mechanism of its regulating effect on lipid metabolism in diabetic conditions remains unclear. The present study investigated the effects of I. lactea-derived proanthocyanidins on lipid metabolism in mice of type 2 diabetes mellitus (T2DM). Results demonstrated a beneficial effect of total proanthocyanidins on dysregulated lipid metabolism and hepatic steatosis in high-fat-diet/streptozocin (STZ)-induced T2DM. To identify the mechanisms, six flavan-3-ols were isolated from proanthocyanidins of I. lacteal and their effects on adipogenesis and dexamethasone (Dex)-induced mitochondrial dysfunctions in 3T3-L1 adipocytes were determined. In vitro studies showed flavan-3-ols inhibited adipogenesis and restored mitochondrial function after Dex-induced insulin resistance, being suggested by increased mitochondrial membrane potential, intracellular ATP contents, mitochondrial mass and mitochondrial biogenesis, and reduced reactive oxygen species. Among the six flavan-3-ols, procyanidin B3 and procyanidin B1 exhibited the strongest effects. Our study suggests potential of proanthocyanidins as therapeutic target for diabetes.

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“…In addition, RRE has been shown to have antioxidant and anti-inflammatory effect, and inhibitory effect on IL-1β, TNF-α and IL-6 production [19,20,42]. Data showing that psychological disorders negatively affect duration of conception are available in the literature [43]. In our study, duration of conception was prolonged in the stress group where oxidative and proinflammatory cytokine levels elevated compared to the healthy and RRE treated groups.…”

Section: Discussionmentioning

confidence: 44%

The effect of rhodiola rosea root extract on stress-induced ovarian damage, infertility and reproductive disorders in female rats

Kadıoğlu¹,

Gündoğdu²,

Kurt³

et al. 2020

Clinical and Experimental Obstetrics & Gynecology

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The aim of the study was to examine the possible effect of Rhodiola rosea root extract (RRE) on ovarian damage, infertility (IF), delay in conception (DC), decrease in the number of offspring (NO) in female rats that have been stressed with compulsory immobilization method (CIM) and on retardation of intrauterine physical development (IPD) in offspring. Materials and methods: Female Albino Wistar rats were divided like: healthy (HG), stress-induced control (SC), and stress + 50 mg/kg RRE (S + REG) groups including sixteen rats in each group. Six rats from each group were killed for conducting biochemical and histopathological examinations in ovarian tissues and others were observed for IF, DC, NO, and IPD. Results: It was found that RRE significantly prevented the increase in oxidative parameters and proinflammatory cytokine levels in ovarian tissue of animals stressed with CIM. RRE suppressed the increase in IF rate and DC whereas caused a decrease in NO and in IPD retardation. Conclusion: These results suggested RRE may have beneficial effects in the treatment of stress induced reproductive dysfunction. Content: The effect of RRE on oxidative and inflammatory changes in ovarian tissue and reproductive changes of animals exposed to stress with compulsory immobilization method.

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Anti-atherosclerosis of oligomeric proanthocyanidins from Rhodiola rosea on rat model via hypolipemic, antioxidant, anti-inflammatory activities together with regulation of endothelial function

Cited by 43 publications

References 73 publications

Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It

Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It

Proanthocyanidins Ameliorated Deficits of Lipid Metabolism in Type 2 Diabetes Mellitus Via Inhibiting Adipogenesis and Improving Mitochondrial Function

The effect of rhodiola rosea root extract on stress-induced ovarian damage, infertility and reproductive disorders in female rats

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