Biochemical Pharmacology volume 81, issue 1, P32-42 2011 DOI: 10.1016/j.bcp.2010.09.002 View full text
Justine Rudner, Simon J. Elsaesser, Verena Jendrossek, Stephan M. Huber

Abstract: The non-steroidal anti-inflammatory drug Celecoxib is a specific inhibitor of cyclooxygenase-2. Apart from its inhibitor function, Celecoxib induces apoptosis through the intrinsic pathway which is controlled by the Bcl-2 family members. In Jurkat T lymphoma cells, treatment with Celecoxib results in a rapid decline of the anti-apoptotic Bcl-2-related protein Mcl-1. The depletion of Mcl-1 is sufficient for apoptosis induction and can be blocked by overexpression of Bcl-xL but not by the close homologue Bcl-2. …

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