Anti-aging properties of Curcuma heyneana Valeton &amp; Zipj: A scientific approach to its use in Javanese tradition

Kusumawati, Idha; Kurniawan, Kresma Oky; Rullyansyah, Subhan; Prijo, Tri Anggono; Widyowati, Retno; Ekowati, Juni; Hestianah, Eka Pramyrtha; Ma’at, Suprapto; Matsunami, Katsuyoshi

doi:10.1016/j.jep.2018.06.038

Cited by 30 publications

(35 citation statements)

References 28 publications

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“…Skin aging can seriously alter a person's physical appearance, which in some cases can have a negative impact on the person's social life. There are two main pathways responsible for the aging process in human skin: firstly, intrinsic aging or natural aging caused by the passage of time or by the deleterious effect of skin matrix metalloproteinases (MMP-1) that degrade structural skin proteins such as collagen fiber (Quan and Fisher, 2015); secondly, extrinsic aging or photoaging that is mostly caused by skin surface exposure to ultraviolet (UV) rays (Kusumawati et al, 2018). ) (Sharma et al, 2012) are known to be toxic in cells.…”

Section: Introductionmentioning

confidence: 99%

Asian hornet Vespa velutina nigrithorax venom: Evaluation and identification of the bioactive compound responsible for human keratinocyte protection against oxidative stress

Silva

Colas

et al. 2020

Toxicon

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The present study aimed to explore the potential use of antioxidant molecules of the Asian hornet venom (Vespa velutina nigrithorax) to prevent or reduce skin aging. We developed a first technical platform that combined a DPPH radical scavenging chemical assay and cytotoxicity and ROS (reactive oxygen species) production in HaCaT keratinocyte cells exposed to UVB to evaluate the antioxidant property of V. velutina venom. We further employed Thin Layer Chromatography (TLC) combined with the DPPH assay as a targeted separation approach to isolate the antioxidant compounds responsible for the free radical scavenging property of V. velutina venom. In parallel, the latter was fractionated by a HPLC-DAD non-targeted separation approach. From this experiment, nine fractions were generated which were again evaluated separately for their antioxidant properties using DPPH assays. Results showed that only one fraction exhibited significant antioxidant activity in which serotonin was identified as the major compound by a UHPLC-ESI-QTOF HRMS/MS approach. We finally demonstrated, using purified serotonin molecule, that this bioactive structure is mostly responsible for the free radical scavenging property of the crude venom as evidenced by DPPH and ROS assays in HaCaT cells exposed to UVB.

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Section: Introductionmentioning

confidence: 99%

Asian hornet Vespa velutina nigrithorax venom: Evaluation and identification of the bioactive compound responsible for human keratinocyte protection against oxidative stress

Silva

Colas

et al. 2020

Toxicon

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“…Rimpang temugiring mengandung senyawa kurkumin [8], yang berpotensi sebagai tabir surya. Sesuai penelitian Kusumawati, et al (2018), aktivitas antioksidan ekstrak temugiring ditentukan secara in vitro menggunakan DPPH, diperoleh nilai IC50 338.18±8.17 µg/mL. Dalam penelitian tersebut diketahui bahwa konsentrasi kurkumin mempunyai korelasi dengan aktivitas antioksidan ekstrak temugiring.…”

Section: Pendahuluanunclassified

“…Hal ini menunjukkan bahwa ekstrak temugiring mengandung senyawa kurkumin yang berpotensi sebagai antioksidan dan sebagai kandidat dalam phytocosmeceutical [9]. Dengan demikian, rimpang temugiring berpotensi sebagai bahan aktif sediaan tabir surya.…”

Section: Pendahuluanunclassified

Pengaruh Variasi Konsentrasi Ekstrak Temugiring (Curcuma heyneana) dalam Sediaan Krim Terhadap Nilai SPF

Syarifah¹,

Andini²,

Alfad³

et al. 2022

J. Islamic Pharm.

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Temugiring (Curcuma heyneana) contains flavonoid and curcumin compounds that have the potential as sunscreen. Therefore, the extract concentration added in the cream formulation must be determined precisely since it may affect the Sun Protection Factor (SPF) value. This research aims to determine the effect of concentration variations of temugiring extract on the SPF value of the temugiring extract cream. In this research, ethanol extract temugiring were obtained by maceration employing ethanol. Then, temugiring extract obtained was formulated in cream formulations with variations in the extract concentration 5%, 7.5%, and 10%. Furthermore, the SPF value was conducted using the UV-Vis spectrophotometry method. The results show that concentration variations of temugiring extract produced different SPF values for each cream formula. The SPF value for formulas 1, 2, and 3 was 3. 307±0.11; 3.497±0.18; 4.966±0.24. Therefore, it can be concluded that the concentration variations of temugiring extract affect the SPF value and creams with concentrations of temugiring extract 5%; 7.5%; and 10% have the potential as sunscreens with minimal until moderate categories.

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“…Rimpang temu giring mengandung minyak atsiri 0,8-3%, amilum, damar, lemak, tanin dan zat pahit, zat warna kuning, saponin, dan flavonoid (Setiawan dkk., 1999;Gunawan dkk., 1989dalam Widyaningsih, 2011. Menurut Kusumawati et al (2018), bagian rimpang temu giring telah digunakan secara tradisional untuk perawatan kulit, kosmetik dan kesegaran tubuh oleh para wanita di Jawa dan Bali. Rimpang temu giring memiliki berbagai bioaktivitas sebagai antioksidan, dan antiinflamasi.…”

Section: Pendahuluanunclassified

Aktivitas Antioksidan Sari Rimpang Temu Giring (Curcuma heyneana) Terfermentasi Lactobacillus bulgaricus

Yustin¹,

Wijayanti²

2018

JC-T

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Temu giring (Curcuma heyneana) telah lama digunakan oleh masyarakat Indonesia terutama untuk menjaga kesehatan kulit. Temu giring mengandung flavonoid dan fenoloik yang dapat dimanfaatkan sebagai antioksidan. Fermentasi pada sari temu giring dilakukan agar senyawa kompleks dipecah menjadi senyawa yang lebih sederhana. Penelitian ini bertujuan untuk mengetahui adanya aktivitas antioksidan sari rimpang temu giring terfermentasi Lactobacillus bulgaricus. Tahap penelitian ini meliputi pembuatan sari rimpang temu giring, fermentasi, identifikasi fitokimia dan pengujian aktivitas antioksidan dengan metode spektrofotometri menggunakan reagen DPPH. Pembuatan sari temu giring dilakukan menggunakan air, selanjutnya difermentasi dengan bakteri Lactobacillus bulgaricus selama 24 jam pada suhu 37°C. Pengujian organoleptis yang dilakukan meliputi warna, bau, rasa serta dilakukan juga uji pH. Hasil identifikasi fitokimia sari temu giring segar dan terfermentasi positif mengandung fenolik dan flavonoid. Sari rimpang temu giring terfermentasi menunjukkan aktivitas antioksidan dengan nilai IC 50 sebesar 3,49 ppm, sehingga dapat disimpulkan bahwa sari rimpang temu giring terfermentasi memiliki aktivitas antioksidan yang tergolong sangat kuat. Kata-kata kunci:antioksidan, fermentasi, temu giring

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Anti-aging properties of Curcuma heyneana Valeton & Zipj: A scientific approach to its use in Javanese tradition

Abstract: The results show that C. heyneana contains antioxidant compounds and has potent anti-aging activity, indicating that it can be used as an anti-aging drug candidate or as a phyto-cosmeceutical.

Cited by 30 publications

References 28 publications

Asian hornet Vespa velutina nigrithorax venom: Evaluation and identification of the bioactive compound responsible for human keratinocyte protection against oxidative stress

Asian hornet Vespa velutina nigrithorax venom: Evaluation and identification of the bioactive compound responsible for human keratinocyte protection against oxidative stress

Pengaruh Variasi Konsentrasi Ekstrak Temugiring (Curcuma heyneana) dalam Sediaan Krim Terhadap Nilai SPF

Aktivitas Antioksidan Sari Rimpang Temu Giring (Curcuma heyneana) Terfermentasi Lactobacillus bulgaricus

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