Anti-adhesive activity of herbal extracts against Campylobacter jejuni

Anti-adhesion activity of thyme (Thymus vulgarisL.) extract, thyme post-distillation waste, and olive (Olea europeaL.) leaf extract againstCampylobacter jejunion polystyrene and intestine epithelial cells

“…With significantly inhibited adhesion of C. jejuni for PSI cl1 and H4 cells promoted by TE treatment, the present study adds to the reports of good potential anti‐adhesion activities for okra fruit extract, liquorice, and other plant extracts . By inhibiting adhesion of Campylobacter to eukaryotic cells, we can thus potentially also modulate Campylobacter pathogenicity.…”

“…According to the study of Botsoglou et al, extract from olive leaves provides a good source of biologically active compounds. 29 In the present study, the major compounds quantified in OE were verbascoside (5), luteolin-7-O-glucoside (6) and oleuropein (7). Considering the extract yield (14.6%), 1.56 mg g −1 of 5, 4.19 mg g −1 of 6, and 27.7 mg g −1 of 7 were extracted from the dried olive leaves.…”

“…With significantly inhibited adhesion of C. jejuni for PSI cl1 and H4 cells promoted by TE treatment, the present study adds to the reports of good potential anti-adhesion activities for okra fruit extract, liquorice, and other plant extracts. 7 By inhibiting adhesion of Campylobacter to eukaryotic cells, we can thus potentially also modulate Campylobacter pathogenicity. The pronounced anti-adhesion activities against C. jejuni for these PSI cl1 and H4 cells were stable and comparable to the adhesion to the abiotic surface, with no significant influence on the adhesion of C. jejuni at concentrations >50 μg mL −1 .…”

“…This situation has, however, become reversed more recently, as a result of increasing antibiotic resistance of microorganisms . Herbs are a source of natural antimicrobials that might also target Campylobacter adhesion . Owing to the existence of a large variety of active compounds, such anti‐adhesive agents have a great advantage in combating infections without selection pressure for the emergence of resistant bacteria, while also not causing deleterious effects to the host microbiota .…”

Alpinia katsumadai Extracts Inhibit Adhesion and Invasion of Campylobacter jejuni in Animal and Human Foetal Small Intestine Cell Lines

“…Consequently, targeting C. jejuni adhesion as a crucial step in the pathogenesis of infection represents an alternative approach to the elimination of potential infection at an early stage. In addition, as anti‐adhesion therapy is not bactericidal, resistance is less likely to occur compared to the more standard antibiotic therapies (Bensch et al , ). Campylobacter spp.…”