Anti–γ-Enolase Autoimmune Retinopathy Manifesting in Early Childhood

Multiomics profiling of APECED peripheral blood highlights compositional increases in alternatively activated B cell subsets

“…Other APECED enriched IgG autoantibody targets of interest were against mast cell alpha beta tryptase TPSAB1, the glycine receptor subunit GLRA1, and neuron specific enolase ENO2. These autoantibody species have been previously observed in Sjogrens (36), Rheumatoid Arthritis (37), motor disorders (38), and eye disease (39), respectively. These autoantibody profiling results help to outline the extent of broken B cell tolerance in our patient cohort and demonstrate patient to patient variability in autoantibody species and levels.…”

“…Other APECED enriched IgG autoantibody targets of interest were against mast cell alpha beta tryptase TPSAB1, the glycine receptor subunit GLRA1, and neuron specific enolase ENO2. These autoantibody species have been previously observed in Sjogrens (36), Rheumatoid Arthritis (37), motor disorders (38), and eye disease (39), respectively.…”

Multiomics profiling of APECED peripheral blood highlights compositional increases in alternatively activated B cell subsets

“…Other APECED enriched IgG autoantibody targets of interest were against mast cell alpha beta tryptase TPSAB1, the glycine receptor subunit GLRA1, and neuron specific enolase ENO2. These autoantibody species have been previously observed in Sjogrens (36), Rheumatoid Arthritis (37), motor disorders (38), and eye disease (39), respectively. These autoantibody profiling results help to outline the extent of broken B cell tolerance in our patient cohort and demonstrate patient to patient variability in autoantibody species and levels.…”

“…Other APECED enriched IgG autoantibody targets of interest were against mast cell alpha beta tryptase TPSAB1, the glycine receptor subunit GLRA1, and neuron specific enolase ENO2. These autoantibody species have been previously observed in Sjogrens (36), Rheumatoid Arthritis (37), motor disorders (38), and eye disease (39), respectively.…”

Autoimmune Retinopathy Mimicking Heritable Retinal Degeneration in a Patient With Common Variable Immune Deficiency

“…6 Typically, however, screening for antiretinal autoantibodies results in multiple bands that range in size and intensity, and it is extremely rare to observe a single pathogenic autoantibody. 7 In this case, multiple circulating antiretinal antibodies were identified, suggesting a humoral component of immune activation. However, we also identified a strong T-cell response, demonstrating that both arms of the immune system are involved in the retinal injury seen in AIR.…”

Proteomic identification of specifically carbonylated brain proteins in APPNLh/APPNLh×PS-1P264L/PS-1P264L human double mutant knock-in mice model of Alzheimer disease as a function of age

“…Further, increased oxidation of alpha-enolase also occurs in other models of AD [57, 67]. Several pathologies are linked to enolase-dependent pathways [68, 69]. …”

Multiomics profiling of APECED peripheral blood highlights compositional increases in alternatively activated B cell subsets

“…Other APECED enriched IgG autoantibody targets of interest were against mast cell alpha beta tryptase TPSAB1, the glycine receptor subunit GLRA1, and neuron specific enolase ENO2. These autoantibody species have been previously observed in Sjogrens (36), Rheumatoid Arthritis (37), motor disorders (38), and eye disease (39), respectively. These autoantibody profiling results help to outline the extent of broken B cell tolerance in our patient cohort and demonstrate patient to patient variability in autoantibody species and levels.…”

“…Other APECED enriched IgG autoantibody targets of interest were against mast cell alpha beta tryptase TPSAB1, the glycine receptor subunit GLRA1, and neuron specific enolase ENO2. These autoantibody species have been previously observed in Sjogrens (36), Rheumatoid Arthritis (37), motor disorders (38), and eye disease (39), respectively.…”

Autoimmune Retinopathy Mimicking Heritable Retinal Degeneration in a Patient With Common Variable Immune Deficiency

“…6 Typically, however, screening for antiretinal autoantibodies results in multiple bands that range in size and intensity, and it is extremely rare to observe a single pathogenic autoantibody. 7 In this case, multiple circulating antiretinal antibodies were identified, suggesting a humoral component of immune activation. However, we also identified a strong T-cell response, demonstrating that both arms of the immune system are involved in the retinal injury seen in AIR.…”

Proteomic identification of specifically carbonylated brain proteins in APPNLh/APPNLh×PS-1P264L/PS-1P264L human double mutant knock-in mice model of Alzheimer disease as a function of age

“…Further, increased oxidation of alpha-enolase also occurs in other models of AD [57, 67]. Several pathologies are linked to enolase-dependent pathways [68, 69]. …”

Multiomics profiling of APECED peripheral blood highlights compositional increases in alternatively activated B cell subsets

“…Other APECED enriched IgG autoantibody targets of interest were against mast cell alpha beta tryptase TPSAB1, the glycine receptor subunit GLRA1, and neuron specific enolase ENO2. These autoantibody species have been previously observed in Sjogrens (36), Rheumatoid Arthritis (37), motor disorders (38), and eye disease (39), respectively. These autoantibody profiling results help to outline the extent of broken B cell tolerance in our patient cohort and demonstrate patient to patient variability in autoantibody species and levels.…”

“…Other APECED enriched IgG autoantibody targets of interest were against mast cell alpha beta tryptase TPSAB1, the glycine receptor subunit GLRA1, and neuron specific enolase ENO2. These autoantibody species have been previously observed in Sjogrens (36), Rheumatoid Arthritis (37), motor disorders (38), and eye disease (39), respectively.…”

Autoimmune Retinopathy Mimicking Heritable Retinal Degeneration in a Patient With Common Variable Immune Deficiency

“…6 Typically, however, screening for antiretinal autoantibodies results in multiple bands that range in size and intensity, and it is extremely rare to observe a single pathogenic autoantibody. 7 In this case, multiple circulating antiretinal antibodies were identified, suggesting a humoral component of immune activation. However, we also identified a strong T-cell response, demonstrating that both arms of the immune system are involved in the retinal injury seen in AIR.…”

Proteomic identification of specifically carbonylated brain proteins in APPNLh/APPNLh×PS-1P264L/PS-1P264L human double mutant knock-in mice model of Alzheimer disease as a function of age

“…Further, increased oxidation of alpha-enolase also occurs in other models of AD [57, 67]. Several pathologies are linked to enolase-dependent pathways [68, 69]. …”