Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls

Abstract

Objective To compare total and regional estimates of body composition, by direct and indirect techniques, for the optimal prediction of CRP among young (9–12 year old), Hispanic girls ( N =232). Methods Standard anthropometric techniques were used to measure height, weight, and waist circumference. Dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) assessed body composition. Fasting serum CRP was measured by the Beckman Coulter AU5812 Clinical Chemistry Analyzer. Associations between each total and regional body composition parameter and CRP were tested using linear regression (log-transformed, continuous CRP) and ordinal logistic regression (CRP < 1.0, ≥1.0–2.9, and ≥ 3.0 mg/L), controlling for maturation, dietary energy, physical activity, and medications. Results All measures of total and regional body fat were positively associated with CRP (P<0.0001), except for intermuscular fat by pQCT. There were no clinically relevant differences in their association with CRP between anthropometric (BMI; waist circumference) and DXA-derived (total fat and regional fat: trunk, gynoid, android fat, leg) measures of fat. Conclusions Measurement of body habitus in Hispanic girls, by multiple commonly available means, predicts CRP equally well.

Association of recurrent common infections and subclinical cardiovascular disease in Mexican women

“…Several studies have found that obesity induces production of pro-inflammatory molecules, promoting a low-level chronic inflammatory state [54][55][56][57], whose relation with aging has also been documented [58,59]. To assess this potential interaction, we conducted stratified analyses using these factors.…”