Anthropometry, Body Fat, and Venous Thromboembolism

Severinsen, Marianne Tang; Kristensen, Søren Risom; Johnsen, Søren Paaske; Dethlefsen, Claus; Tjønneland, Anne; Overvad, Kim

doi:10.1161/circulationaha.109.863241

Cited by 120 publications

(105 citation statements)

References 23 publications

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“…Indeed Choy et al, 28 showed an association between increased WC and raised blood pressure. Although several studies have shown that a larger HC is protective against HT and metabolic diseases 29,30 , our study showed such protection in males only while larger HC was associated with higher blood pressure in females. Some of these studies which showed that a large HC confers protection against CVDs also demonstrated that without controlling for BMI or WC, HC was associated with higher blood pressure in females 33,34 .…”

contrasting

confidence: 90%

Association of waist and hip circumferences with the presence of hypertension and pre-hypertension in young South African adults

2015

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Background: Obesity is one of the most important risk factors for cardiovascular diseases (CVDs) including hypertension (HT) which is itself a risk factor for CVDs. Recent studies suggest that waist circumference (WC) may be more sensitive than Body Mass Index (BMI) in determining individual risk scores for CVDs. Objectives: The current study aimed at investigating the influence of various anthropometric variables on blood pressure status in a group of students from Walter Sisulu University. Methods: Informed consent was obtained from 216 male and female students from Walter Sisulu University with a mean age of 22.1±0.2 years. Anthropometric measurements were performed for each participant. Blood pressure was measured in triplicates after 10 minutes of rest and the average computed. Results: Just over 46% of the subjects were diagnosed with hypertension (HT) and pre-HT. The gender specific prevalence of HT/pre-HT was higher in the male (76.7%) compared to the female (30.5%) group. Waist circumference (WC) and total body fat (TBF) correlated significantly with blood pressure and HT/pre-HT in females but not males. ROC analysis showed that with the exception of waist-to-hip (WHR), all other anthropometric measurements and ratios studied can be used to discriminate blood pressure in young adult females not males. Sci. 2015 15(3):908-16. doi: http://dx.doi.org/10.4314/ahs.v15i3.27 Conclusion

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confidence: 90%

Association of waist and hip circumferences with the presence of hypertension and pre-hypertension in young South African adults

2015

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“…Our study was confined to women, but other prospective studies have found a similar relationship between increasing body size and venous thromboembolism risk for men in the absence of surgery, 28,30,31,49,50 as have studies in which sex-adjusted estimates were reported. 51,52 Previous studies that explored the independent effects of obesity on venous thromboembolism risk following surgery have not reported sex-specific analyses, 8 -15 so it is not known whether the relationship differs between women and men.…”

Section: Strengths and Limitationssupporting

confidence: 64%

“…[27][28][29][30][31] Overall, previous prospective studies have reported a 2-to 3-fold increased risk of venous thromboembolism associated with a body mass index Ն30 kg/m 2 in comparison with women who were not overweight or obese. [27][28][29][30][31][32][33] These studies included far fewer participants and cases of venous thromboembolism than this study and consequently their power to undertake detailed explorations of risk was limited; the study with the largest number of cases, the Iowa Women's Health Study, 29 included only 463 events that did not occur after surgery, a recent cancer diagnosis, or another acute precipitating event (compared with Ͼ4000 events included here).…”

Section: Findings In Relation To Previous Studiesmentioning

confidence: 93%

Body Mass Index, Surgery, and Risk of Venous Thromboembolism in Middle-Aged Women

Parkin

Sweetland²,

Balkwill³

et al. 2012

Circulation

111

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FRS, for the Million Women Study CollaboratorsBackground-Obesity and surgery are known risk factors for venous thromboembolism (VTE), but there is limited information about the independent effects of obesity on the incidence of postoperative VTE. We linked questionnaire data from the Million Women Study with hospital admission and death records to examine the risk of VTE in relation to body mass index (BMI) both in the absence of surgery and in the first 12 weeks following an operation. Methods and Results-Overall, 1 170 495 women (mean age, 56.1 years) recruited in 1996 to 2001 through the National Health Service Breast Screening Programme in England and Scotland were followed for an average of 6 years, during which time 6438 were admitted to hospital or died of VTE. The adjusted relative risks of VTE increased progressively with increasing BMI and women with a BMI Ն35 kg/m 2 were 3-4 times as likely to develop VTE as those with a BMI 22.5 to 24.9 (relative risk 3.45 [95% CI 3.09 -3.86]). Overweight and obese women were more likely than lean women to be admitted for surgery and also to develop postoperative VTE. During a 12-week period without surgery, the incidence rates of VTE per 1000 women with a BMI Ͻ25 and Ն25 were 0.10 (0.09 -0.10) and 0.19 (0.18 -0.20); the corresponding rates in the 12 weeks following day and inpatient surgery were, respectively, about 4 and 40 times higher. Conclusions-VTE risk increases with increasing BMI and the associated excess risk is much greater after surgery than without surgery. (Circulation. 2012;125:1897-1904.)

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“…Our inability to establish a statistically significant impact of smoking on the risk of VTE may be attributable to the fact that information regarding smoking was available on only 65% of the cohort. The consistent risks of smoking for VTE in the general population were established by studies with much larger sample sizes (4000 to 1.1 million individuals) (38)(39)(40)(41)(42)(43). Likewise, the lack of a protective association between antiplatelet or HMG-CoA reductase inhibitor use and VTE risk may relate to the sample size.…”

Section: Discussionmentioning

confidence: 97%

Venous Thromboembolism in Patients with Membranous Nephropathy

Lionaki¹,

Derebail²,

Hogan³

et al. 2012

Clinical Journal of the American Society of Nephrology

188

148

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SummaryBackground and objectives The aims of this study were to determine the frequency of venous thromboembolic events in a large cohort of patients with idiopathic membranous nephropathy and to identify predisposing risk factors.Design, setting, participants, & measurements We studied patients with biopsy-proven membranous nephropathy from the Glomerular Disease Collaborative Network (n=412) and the Toronto Glomerulonephritis Registry (n=486) inception cohorts. The cohorts were pooled after establishing similar baseline characteristics (total n=898). Clinically apparent and radiologically confirmed venous thromboembolic events were identified. Potential risk factors were evaluated using multivariable logistic regression models.Results Sixty-five (7.2%) subjects had at least one venous thromboembolic event, and this rate did not differ significantly between registries. Most venous thromboembolic events occurred within 2 years of first clinical assessment (median time to VTE = 3.8 months). After adjusting for age, sex, proteinuria, and immunosuppressive therapy, hypoalbuminemia at diagnosis was the only independent predictor of a venous thromboembolic event. Each 1.0 g/dl reduction in serum albumin was associated with a 2.13-fold increased risk of VTE. An albumin level ,2.8 g/dl was the threshold below which risk for a venous thromboembolic event was greatest.Conclusions We conclude that clinically apparent venous thromboembolic events occur in about 7% of patients with membranous nephropathy. Hypoalbuminemia, particularly ,2.8 g/dl, is the most significant independent predictor of venous thrombotic risk.

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Anthropometry, Body Fat, and Venous Thromboembolism

Cited by 120 publications

References 23 publications

Association of waist and hip circumferences with the presence of hypertension and pre-hypertension in young South African adults

Association of waist and hip circumferences with the presence of hypertension and pre-hypertension in young South African adults

Body Mass Index, Surgery, and Risk of Venous Thromboembolism in Middle-Aged Women

Venous Thromboembolism in Patients with Membranous Nephropathy

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