Anthropometric charts and congenital anomalies in newborns with Down syndrome

Mircher, Clotilde; Toulas, Jeanne; Cieuta‐Walti, Cécile; Marey, Isabelle; Conte, Martine; Briceño, Laura González; Tanguy, Marie‐Laure; Rethoré, M O; Ravel, Aimé

doi:10.1002/ajmg.a.38305

Cited by 12 publications

(10 citation statements)

References 33 publications

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“…In our previous study, we found no difference between Toledo's study and ours for birth OFC measurement for boys and girls (Mircher et al, ). When we compared OFC at age 14, we found no difference between Toledo's study and ours for boys, whereas our girls' OFC was slightly bigger, but we miss data to perform statistical comparisons.…”

Section: Discussioncontrasting

confidence: 63%

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Growth curves for French people with Down syndrome from birth to 20 years of age

Mircher

Briceño

Toulas

et al. 2018

American J of Med Genetics Pt A

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We present new and complete growth charts for 2,598 healthy French children and adolescents with Down syndrome (DS) from 0 to 20 years old, obtained with highly reliable statistical methods. This study is retrospective and addresses data collected over a period of 12 years, monocentric and with a satisfactory representation of the population nationwide. Final occipito‐frontal circumference (OFC) is at the fifth percentile compared to WHO charts, with a drop between 12 and 18 months. Final height is at the first percentile compared to WHO charts for girls and boys with two periods of reduced growth velocity: before 36 months and around puberty. We observed no pubertal growth peak for girls. For boys, pubertal growth peak showed to happen earlier and to be less significant than in the general population. When compared to a previous French study with people affected with DS, pubertal growth acceleration begins at a later age for girls and boys; girls in our study are taller at age 15 (+5 cm), but there is no difference for boys at this age. Overweight is more frequent compared to the typical French population. Mean body mass index (BMI) rises rapidly above the 75th percentile of typical French children as early as age 4, with an earlier age for precocious adiposity rebound. The second period for rapid increase of BMI is around 14 years old. When compared to a previous French study with DS, we did not observe any BMI increase, at least up to the age of 14.

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Section: Discussioncontrasting

confidence: 63%

“…Therefore, there seems to be two slowdown periods in OFC growth: just before full term (Mircher et al, ) and around 12 months. Several authors have also observed a slowdown between age 0 and 4 (Myrelid et al, ), but some of them earlier than us, around 6 months (Palmer et al, ; Tuysuz et al, ).…”

Section: Discussionmentioning

confidence: 99%

Growth curves for French people with Down syndrome from birth to 20 years of age

Mircher

Briceño

Toulas

et al. 2018

American J of Med Genetics Pt A

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“…The mean birth weight and birth length is reduced in new-borns with DS, with mean birth weight closer to the mean of unaffected children than birth length (6). Reduced growth rate leading to short stature in adult age is a well-known characteristic of most persons with DS.…”

Section: Nutritional Statusmentioning

confidence: 99%

“…Growth charts for persons with DS from birth to 18 or 20 years of age have been developed based on several national cohorts (40)(41)(42)(43)(44)(45)(46). Traditionally growth curves may be useful in children to monitor growth and nutritional status.…”

Section: Nutritional Statusmentioning

confidence: 99%

Nutritional challenges in children and adolescents with Down syndrome

Nordstrøm

Retterstøl

Hope

et al. 2020

The Lancet Child & Adolescent Health

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Several features and comorbidities in DS have nutritional implications and consequences, which needs to be addressed in further detail. In this review, we searched and assessed the literature from year 2000-2019 and found in total 57 nutritionally relevant articles.In infancy and early childhood, children with DS have high risk of oral motor difficulties and pharyngeal dysphagia with aspiration, which requires systematic attention. To improve nutritional status in children with underweight and clinical signs of feeding problems further evaluation of underlying causes is required. Clinical interventions should promote swallowing safety and development of feeding abilities.Already from 4-5 years of age overweight may become a concern. To prevent disease later in life, there is an urgent need for more research on nutritional aspects in prevention and treatment of obesity for adolescents with DS. The present review did not find any data to support the use of dietary supplementation except when deficiency is documented. In addition, the literature presented clearly documents the need for more research using larger study samples, and control groups, addressing important nutritional challenges in children and adolescents with DS.

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“…El RN con SD también se asocia a un peso de nacimiento inferior al de la población general 28,30,35 . Nuestro 26,4% fue inferior al 30% descrito en otra cohorte chilena y superior a otra con 12% de pacientes con peso menor a 2.000 g y EG promedio de 37,3 semanas 6,13 .…”

Section: Discussionunclassified

Anomalías congénitas y comorbilidad en neonatos con Síndrome de Down

et al. 2020

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El Síndrome de Down se presenta en 2,5 de 1.000 recién nacidos vivos chilenos. Presentan más anomalías congénitas y comorbilidades que la población general, aumentando su tasa de hospitalización.Objetivo: Describir las anomalías congénitas y comorbilidades de neonatos con Síndrome de Down nacidos y/u hospitalizados en la década 2008-2018.Pacientes y Método: Retrospectivamente se revisaron registros de los pacientes nacidos y/u hospitalizados dentro de sus 28 días de vida entre el 1 de enero de 2008 y el 31 de diciembre de 2018. Para cada paciente se consignó: edad materna, antecedentes familiares de Síndrome de Down, antecedentes pre y perinatales y resultado de estudio genético. Se consignó la edad al ingreso, el motivo principal de ingreso, comorbilidades, días de hospitalización y fallecimiento. Se excluyeron dos pacientes con más del 50% de ficha incompleta. Se exploraron asociaciones entre morbilidades, anomalías y fallecimiento.Resultados: 140 de 79.506 (0,2%) recién nacidos vivos fueron diagnosticados con Síndrome de Down en el período neonatal. 24,7% fueron prematuros y 26,4% tuvieron bajo peso para su edad gestacional. Los porcentajes de morbilidad y hospitalización fueron 83,6% y 90%. La principal causa de ingreso fue la poliglobulia, y la más frecuente hiperbilirrubinemia. Fallecieron 4 pacientes (2,9%) y 70,7% presentó alguna una anomalía congénita, principalmente cardíaca. La mediana de edad materna fue de 36 años y 57,1% tenía 35 años o más.Conclusiones: Esta investigacion aporta información relevante para optimizar el manejo perinatal y el seguimiento de los pacientes con Síndrome de Down

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Anthropometric charts and congenital anomalies in newborns with Down syndrome

Cited by 12 publications

References 33 publications

Growth curves for French people with Down syndrome from birth to 20 years of age

Growth curves for French people with Down syndrome from birth to 20 years of age

Nutritional challenges in children and adolescents with Down syndrome

Anomalías congénitas y comorbilidad en neonatos con Síndrome de Down

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