Anthralin minute entire skin treatment. A new outpatient therapy for psoriasis

Schwarz, T.

doi:10.1001/archderm.121.12.1512

Cited by 7 publications

(3 citation statements)

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“…In a split comparison study to determine the optimal period of anthralin application, 10 minutes of anthralin contact time gave maximum antipsoriatic activity with minimal side effects. Dosimetry variables for AMEST were employed based on patient’s pigmentation type, erythematous response, therapeutic effect, and so on 41,42 . Treatment of 43 patients resulted in complete clearing in 31 patients (72%), with 90% improvement in two patients (5%) and <90% clearing in seven patients (16%).…”

Section: Methodsmentioning

confidence: 99%

Anthralin/dithranol in dermatology

Sehgal¹,

Verma

Khurana

2014

Int J Dermatology

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Anthralin (1,8-dihydroxy-9anthrone, dithranol) was first synthesized as a derivative of chrysarobin, prepared from the araroba tree in Brazil over a century ago. Drawbacks to the use of anthralin include irritation and discoloration of the skin. This property of the molecule prompted workers to investigate details of its pharmacology, mode of action, and indications. The major point of this article is to highlight and revisit these aspects for pertinent future use. Therefore, it is worthwhile to consider that the drug is relatively innocuous, yet effective, and is devoid of any systemic side effects in contrast to a wide variety of systemic and topical therapies available for psoriasis and other dermatoses.

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Section: Methodsmentioning

confidence: 99%

Anthralin/dithranol in dermatology

Sehgal¹,

Verma

Khurana

2014

Int J Dermatology

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“…These results are superior to those of a study from 1983, in which less than 40% had more than 75% improvement in lesions after 6 weeks [5]. Dithranol treatment of adults at daycare centers has been reported to result in clearing in 63–77% of the patients after 14–42 treatment days [6,7,8]. …”

Section: Discussionmentioning

confidence: 82%

Dithranol Therapy in Childhood Psoriasis: Unjustifiably on the Verge of Falling into Oblivion

et al. 2010

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Background: In childhood psoriasis, physicians aim for an effective and safe treatment such as with dithranol. This study presents the largest study of dithranol-treated patients described in the literature. Objective: The aim of the study was to determine the position of dithranol in the treatment strategy for psoriasis. Methods: All juvenile patients receiving dithranol treatment at our center were evaluated retrospectively. Results: Sixty patients (with 82 treatment episodes in total) were included. The mean age at the start of dithranol treatment was 11.1 years (range: 3.7–17.9 years). The result of the treatment was: excellent (3.7%), good (69.5%), moderate (8.5%), reasonable (13.4%) or disappointing (4.9%). Mild irritation was seen in 39%, and severe irritation in 63% of the patients. Conclusions: Dithranol can be regarded as an efficacious and safe topical therapy for the treatment of childhood psoriasis. It is a valuable alternative topical treatment which should not be disregarded in the treatment regimen for childhood psoriasis and should be commenced before ultraviolet or systemic treatments are initiated.

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“…Short-contact anthralin therapy has been found to be equally effective with less associated irritation or staining. [35][36][37][38] Another development used to ameliorate anthralin-induced side effects is the ajplication of 10% triethanolamine following anthralin. 3 Recently, a product containing triethanolamine, has been made available for this use and is effective in reducing staining of skin, hair, nails, and fabrics when used before and after removal of the anthralin.…”

Section: Journal Of Cutaneous Medicine and Surgerymentioning

confidence: 99%