Anthralin. Different concentration effects on epidermal cell DNA synthesis rates in mice and clinical responses in human psoriasis

Lowe, Nicholas J.

doi:10.1001/archderm.117.11.698

Cited by 12 publications

(8 citation statements)

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“…Several important practical points arise from this study. The results obtained using dithranol solution confirm those of Lowe & Breeding (1981) using a similar hairless mouse model. It is of interest that there is no significant local inhibition of epidermal DNA synthesis at concentra-tions below o 05% since this supports accepted clinical practice that such low concentrations of dithranol are therapeutically ineffective.…”

Section: Discussionsupporting

confidence: 76%

The effect on epidermal DNA synthesis of a combination of topical steroid with either dithranol or tar as used for psoriasis

Clement¹,

Hehir²,

Phillips³

et al. 1983

Br J Dermatol

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The hairless mouse was used to investigate the effects of a combination of glucocorticosteroid with either dithranol or tar on epidermal DNA synthesis, in order to determine whether such combinations reduce epidermal DNA synthesis more effectively than the single agents. Dithranol alone produced a significant local inhibition of DNA synthesis at concentrations of 0.1% and 0.05% but not at lower concentrations. Dose-response data for dilutions of clobetasol propionate and betamethasone 17-valerate showed progressive diminution of both local and systemic effects with decreasing concentrations. An additive effect was found from combining clobetasol propionate with dithranol and from combining betamethasone 17-valerate with liquor picis carbonis. These combined preparations were tested again after storage for 6 months and 2 months respectively and showed no loss of efficacy. These results lend justification to the use of these combined preparations in the treatment of psoriasis.

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Section: Discussionsupporting

confidence: 76%

The effect on epidermal DNA synthesis of a combination of topical steroid with either dithranol or tar as used for psoriasis

Clement¹,

Hehir²,

Phillips³

et al. 1983

Br J Dermatol

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“…Usually, this agent is applied in increasing concentrations from 0.05 to 4%. Comparative studies demonstrated its efficacy also in a low -0.1% concentration [23] . Low-strength formulations are not only active, as also confirmed by light microscopy, transmission electron and scanning electron microscopy, but also less irritating and staining [24] .…”

Section: Discussionmentioning

confidence: 90%

In Search for New Antipsoriatic Agents: NAD<sup>+</sup> Topical Composition

Woźniacka

Szajerski

Adamus

et al. 2006

Skin Pharmacol Physiol

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The aim of the study was to examine the effectiveness of the oxidized form of nicotinamide adenine dinucleotide (NAD⁺), adenosine precursor, in 37 patients suffering from psoriasis. As NAD⁺ is known to be relatively unstable, the second goal was to establish the proper conditions for the satisfactory stability of topical NAD⁺ composition. In each patient, two matching plaques were selected for the study. Topical treatment with 1 or 0.3% NAD⁺ in Vaseline ointment administered twice daily was compared with overnight therapy with 0.1% anthralin applied for 12 h and placebo. The enzymatic method was applied to determine the stability of NAD⁺ in Vaseline ointment. After a 4-week application, the reduction in erythema, infiltration and desquamation caused by 1 or 0.3% topical NAD⁺ composition was similar to the reduction caused by 0.1% anthralin. It was demonstrated that NAD⁺ underwent a considerable decomposition at room temperature, while it was sufficiently stable at 5°C; thus, for a longer use the agent should be stored at fridge temperature. NAD⁺ therapy combines good efficacy, cosmetic acceptability and convenient twice-daily application.

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“…Tar is thought to exert its antipsoriatic effects by suppressing epidermal DNA synthesis. 29,30 Tar is available in numerous preparations and is successfully compounded with salicylic acid and also with betamethasone. 31 Acceptable patient compliance with tar is dif®cult to attain because it is a messy compound that stains.…”

Section: Anthralin and Tarmentioning

confidence: 99%

Drug Interactions in Psoriasis: The Pros and Cons of Combining Topical Psoriasis Therapies

Endzweig-Gribetz¹,

Brady²,

Lynde³

et al. 2002

Journal of Cutaneous Medicine and Surgery: Incorporating Medica

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Anthralin. Different concentration effects on epidermal cell DNA synthesis rates in mice and clinical responses in human psoriasis

Cited by 12 publications

References 0 publications

The effect on epidermal DNA synthesis of a combination of topical steroid with either dithranol or tar as used for psoriasis

The effect on epidermal DNA synthesis of a combination of topical steroid with either dithranol or tar as used for psoriasis

In Search for New Antipsoriatic Agents: NAD<sup>+</sup> Topical Composition

Drug Interactions in Psoriasis: The Pros and Cons of Combining Topical Psoriasis Therapies

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