Antagonistic Action of Lactobacilli and Bifidobacteria in Relation to Staphylococcus aureus and Their Influence on the Immune Response in Cases of Intravaginal Staphylococcosis in Mice

Abstract

The antibacterial activity of Lactobacillus casei IMV B-7280, Lact. acidophilus IMV B-7279, Bifidobacterium longum VK1, and B. bifidum VK2 strains or their various compositions in relation to Staphylococcus aureus in vitro and on models of experimental intravaginal staphylococcosis of mice was determined. It was found that under the influence of these strains and their various compositions, the in vitro growth of Staph. aureus was inhibited, and the number of colonies of Staph. aureus plated from the vagina of infected mice was significantly reduced. The antibacterial activity of these strains separately and in compositions correlated with their ability to improve the performance of the immune response. These strains were the most effective in the following compositions: Lact. casei IMV B-7280— B. longum VK1— B. bifidum VK2. Strains of Lact. casei IMV B-7280, Lact. acidophilus IMV B-7279, B. bifidum VK2, and B. longum VK1 are prospective components of future probiotic drugs efficient in treating staphylococcosis and for immunity correction.

Preventive effect ofLactobacillus reuteriCRL1324 on Group BStreptococcusvaginal colonization in an experimental mouse model

“…, ; Lazarenko et al . ). However, the preventive effect of lactobacilli on GBS in animal experimental models was not evidenced up today.…”

“…), and can activate the immune system, improving the host's response against urogenital pathogens (Lazarenko et al . ; Wagner and Johnson ). In the present work, the i.va.…”

“…Several research groups have evidenced through in vitro studies that lactobacilli strains inhibit the growth of GBS by production of metabolites as organic acids and bacteriocin-like substances (Bodaszewska et al 2010;Ju arez Tom as et al 2011;Ruiz et al 2012;De Gregorio et al 2014). Some other publications have demonstrated the in vivo protective effect of different lactobacilli strains on several urogenital microorganisms by using a murine experimental model (Pascual et al 2010;Joo et al 2011Joo et al , 2012Lazarenko et al 2012). However, the preventive effect of lactobacilli on GBS in animal experimental models was not evidenced up today.…”

Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity

“…These results suggest the potential using of probiotics in order to alleviate the occurrence of metabolic diseases by less radical approach comparing with drugs or hormone therapy. We showed that preliminary selected and characterized probiotic strains of Lactobacillus casei IMV B-7280, Bifidobacterium animalis VKL, B. animalis VKB and their various compositions have high ability to balance immune response to infectious diseases [15] and are able to effectively prevent MSG-obesity in rats [16].…”

Lectin Systems Imitating Probiotics: Potential and Prospects for Biotechnology and Medical Microbiology

“…It takes place multisynergism of anti-Candida action between PBL and antibiotics (azoles, amphotericin B, nystatin). Taken together, PBL imitate anti-Staphylococcus and anti-Candida activities of probiotic lactobacilli and bifidobacteria [33,34] and can be potentially used for treatment of candidoses and staphylococcoses.…”