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“…In fact, it was emphasized that insulin injection could be used as a challenge to test the functional integrity of vagus fibers to the stomach. At one time, insulin effect on gastrointestinal (GI) motility was recommended as a model to compare prokinetic drugs on GI motility, which is comparable to metoclopramide [ 18 , 19 ]. In addition, it was also reported that insulin may have a permissive role in maintaining basal pattern motility in the sheep intestine [ 20 ].…”
Section: Discussionmentioning
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“…In fact, it was emphasized that insulin injection could be used as a challenge to test the functional integrity of vagus fibers to the stomach. At one time, insulin effect on gastrointestinal (GI) motility was recommended as a model to compare prokinetic drugs on GI motility, which is comparable to metoclopramide [ 18 , 19 ]. In addition, it was also reported that insulin may have a permissive role in maintaining basal pattern motility in the sheep intestine [ 20 ].…”
Section: Discussionmentioning
“…Some contrasting reports are also available about production of depressant effect on GI motility by releasing norepinephrine in rats [ 21 , 22 ] and some attributed this inhibitory effect due to hyperpolarization of smooth muscle [ 23 ] or to the phenol content of commercial insulin [ 24 ]. Moreover, these observations were recorded at higher concentrations of insulin [ 14 , 18 , 20 ].…”
Section: Discussionmentioning