Another glimpse over the salting-out assisted liquid–liquid extraction in acetonitrile/water mixtures

An Insight on Salting‐out Assisted Liquid–Liquid Extraction for Phytoanalysis

“…One of the most important parameters in SALLE is the type of salt used as salting-out agent (Valente et al, 2013a). The salts used for these studies were selected according to our previous results (Valente et al, 2013a).…”

Salting-out assisted liquid-liquid extraction method coupled to gas chromatography for the simultaneous determination of thujones and pulegone in beverages

“…The main factors affecting the extraction such as type of salt and its amount, type of organic solvent, vortex and centrifuge times were investigated. Acetonitrile is the most widely used solvent for SALLE [20] and has many attractive properties such as the good miscibility with water, its favourable polarity that facilitates the extraction of a wide range of compounds and furthermore, can be directly injected to GC instruments. Acetonitrile is also less harmful to the environment compared to the other common liquid extraction solvents.…”

Recent advances in sample preparation techniques to overcome difficulties encountered during quantitative analysis of small molecules from biofluids using LC-MS/MS

“…54 A more convenient way to achieve phase separation between an aqueous sample and a water-miscible solvent is salt-assisted liquid-liquid extraction (SALLE), where the polarity of the aqueous phase is increased by adding high concentration of salt, leading to phase separation. 55 This approach has been used for quantitation of pharmaceutical compounds from biouids using LC 56 or LC-MS/MS. [57][58][59] Novel sample preparation methods Many common interferents can be removed with conventional sample preparation methods (e.g.…”