Anosognosia for theory of mind deficits: A single case study and a review of the literature

Pacella, Valentina; Scandola, Michele; Beccherle, Maddalena; Bulgarelli, Cristina; Avesani, Renato; Carbognin, Giovanni; Agostini, Giulia; Schotten, Michel Thiebaut de; Moro, Valentina

doi:10.1016/j.neuropsychologia.2020.107641

Cited by 14 publications

(10 citation statements)

References 98 publications

(118 reference statements)

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“…However, recent advances relating to the techniques used for the collection and analysis of neuroimaging data indicate that if neuroanatomical investigations are limited to the mapping of lesions (i.e. an analysis of the direct, discrete lesions), there is a risk that the work on the brain is oversimplified and this may impede the understanding of those symptoms that are due to functional impairments in regions that are distant from the site of the damage [15,17]. Diaschisis (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, the patient's lesions were compared to data from an anatomical atlas (AAL, http://www. cyceron.fr/web/aal anatomical automatic labeling.html) and the tractography reconstruction of one hemisphere was compared with the reconstruction of its homologue (a procedure already followed in previous studies; [17,23]). Finally, we also consider that the patient's MRI shows signs of cortical atrophy that have not yet been specifically investigated.…”

Section: How the Analysis Of The Disconnections Helps Us To Understanmentioning

confidence: 99%

“…In the present study, our aim was to overcome these limitations and take advantage of recent methodological advances in the neuroimaging of structural connectivity that have already proven to be fruitful in the study of neuropsychological deficits [15][16][17]. The objective was to investigate the contribution of white matter tract disconnections in the clinical manifestation of AHS.…”

Section: Introductionmentioning

confidence: 99%

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The Role of White Matter Disconnection in the Symptoms Relating to the Anarchic Hand Syndrome: A Single Case Study

Pacella¹,

Ricciardi²,

Bonadiman³

et al. 2021

Preprint

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The anarchic hand syndrome refers to an inability to control the movements of one’s own hand which acts as if it had a will of its own. The symptoms may differ depending on whether the brain lesion is anterior, posterior, callosal or subcortical, but the relative classifications are not conclusive. This study investigates the role of white matter disconnections in a patient whose symptoms are inconsistent with the mapping of the lesion site. A repeated neuropsychological investigation was associated with a review of the literature on the topic to identify the frequency of various different symptoms relating to this syndrome. Furthermore, an analysis of the neuroimaging regarding structural connectivity allowed us to investigate the grey matter lesions and white matter disconnections. The results indicated that some of the patient’s symptoms were associated with structures that, although not directly damaged, were dysfunctional due to a disconnection in their networks. This suggests that the anarchic hand may be considered as a disconnection syndrome involving the integration of multiple antero-posterior, insular and interhemispheric networks. In order to comprehend this rare syndrome better, the clinical and neuroimaging data need to be integrated with the clinical reports available in the literature on the topic.

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Section: Discussionmentioning

confidence: 99%

Section: How the Analysis Of The Disconnections Helps Us To Understanmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Role of White Matter Disconnection in the Symptoms Relating to the Anarchic Hand Syndrome: A Single Case Study

Pacella¹,

Ricciardi²,

Bonadiman³

et al. 2021

Preprint

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“…A considerable amount of evidence indicates that the cognitive processes supporting human Theory of Mind capacities are both associated with identifiable neural correlates (see Heleven & Van Overwalle 2018) and distinct from more generalized executive function in the brain (see e.g. Hartwright et al 2015;Samson et al 2015;Bradford et al 2020;Pacella et al 2020). If the knowledge-centric Theory of Mind program is to achieve success comparable to that of its belief-centric counterpart, this observation is key.…”

Section: Main Textmentioning

confidence: 99%

Knowledge and the Brain: Why the Knowledge-Centric Theory of Mind Program Needs Neuroscience

Bricker¹

2021

Preprint

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The knowledge-centric Theory of Mind research program suggested by Phillips et al. stands to gain significant value by embracing a neurocognitive approach that takes full advantage of techniques like fMRI and EEG. This neurocognitive approach has already begun providing important insights into the mechanisms of knowledge attribution, insights which support the claim that it is more basic than belief attribution.

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“…In the present study, our aim was to overcome these limitations and take advantage of recent methodological advances in the neuroimaging of structural connectivity that have already proven to be fruitful in the study of neuropsychological deficits [ 15 , 16 , 17 ]. The objective was to investigate the contribution of white matter tract disconnections in the clinical manifestation of AHS.…”

Section: Introductionmentioning

confidence: 99%

The Role of White Matter Disconnection in the Symptoms Relating to the Anarchic Hand Syndrome: A Single Case Study

et al. 2021

Self Cite

View full text Add to dashboard Cite

The anarchic hand syndrome refers to an inability to control the movements of one’s own hand, which acts as if it has a will of its own. The symptoms may differ depending on whether the brain lesion is anterior, posterior, callosal or subcortical, but the relative classifications are not conclusive. This study investigates the role of white matter disconnections in a patient whose symptoms are inconsistent with the mapping of the lesion site. A repeated neuropsychological investigation was associated with a review of the literature on the topic to identify the frequency of various different symptoms relating to this syndrome. Furthermore, an analysis of the neuroimaging regarding structural connectivity allowed us to investigate the grey matter lesions and white matter disconnections. The results indicated that some of the patient’s symptoms were associated with structures that, although not directly damaged, were dysfunctional due to a disconnection in their networks. This suggests that the anarchic hand may be considered as a disconnection syndrome involving the integration of multiple antero-posterior, insular and interhemispheric networks. In order to comprehend this rare syndrome better, the clinical and neuroimaging data need to be integrated with the clinical reports available in the literature on this topic.

show abstract

Anosognosia for theory of mind deficits: A single case study and a review of the literature

Cited by 14 publications

References 98 publications

The Role of White Matter Disconnection in the Symptoms Relating to the Anarchic Hand Syndrome: A Single Case Study

The Role of White Matter Disconnection in the Symptoms Relating to the Anarchic Hand Syndrome: A Single Case Study

Knowledge and the Brain: Why the Knowledge-Centric Theory of Mind Program Needs Neuroscience

The Role of White Matter Disconnection in the Symptoms Relating to the Anarchic Hand Syndrome: A Single Case Study

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