“…Importantly, in addition to enabling large-scale lesion studies, modern neuroimaging techniques have also enabled researchers to create detailed population-scale brain atlases that delineate the boundaries of regional grey matter parcels and map the trajectories of inter-regional white matter connections (Power et al, 2011;Rojkova et al, 2016;Yeh et al, 2018;Yeo et al, 2011). These atlases can be integrated with empirical lesion data to quantify a lesion's expected impact on specific grey matter regions and white matter connections (Carter et al, 2012;Catani et al, 2012;Foulon et al, 2018;Fridriksson et al, 2013;Griffis et al, 2020Griffis et al, , 2019Griffis et al, , 2017aGriffis et al, , 2017bHope et al, 2015;Kuceyeski et al, 2015Kuceyeski et al, , 2016Pacella et al, 2019;Thiebaut De Schotten et al, 2014), enabling advanced, anatomically-informed lesion analyses that can account for both the focal damage and distributed disconnections caused by lesions. Atlas-based lesion quantification approaches typically involve first registering a patient's lesion to the same brain coordinate space as the desired brain atlas, and then embedding the lesion into the atlas to estimate the amount of damage/disconnection sustained by the structures of interest (Catani et al, 2012;De Schotten and Foulon, 2018;Forkel and Catani, 2018).…”