“…128 OECs produce growth factors, nerve growth factor 129 (NGF), brain-derived neurotrophic factor (BDNF), glial 130 cell-derived neurotrophic factor (GDNF), and ciliary neu-131 rotrophic factor (CNTF), cell adhesion molecules, and 132 extracellular matrix proteins that are beneficial for axonal 133 regeneration (Woodhall et al 2001;Pellitteri et al 2009;134 Pastrana et al 2006). Olfactory ensheathing cell-condi-135 tioned medium (OECCM) reverts SH-SY5Y damage 136 induced by 6 hydroxydopamine (6OHDA) (Shukla et al 137 2014) and astrocyte damage induced by H 2 O 2 (Jinbo et al 138 2013;Liu et al 2013). Furthermore, OECCM increased 139 oligodendroglial and neuronal differentiation of neural 140 progenitor cells (Carvalho et al 2014) and human mes-141 enchymal stem cells (Zeng et al 2013) (Yang et al 2016), Ab [25][26][27][28][29][30][31][32][33][34][35] 179 (Sangon Biotech, Shanghai, China) was dissolved in ster-180 ilized, double-distilled, water at a concentration of 1 mM 181 and incubated in a capped vial at 37°C for 7 days to form 182 an aggregated form.…”