Annular Elastolytic Giant Cell Granuloma Heralding Onset and Recurrence of Acute Myelogenous Leukemia

Garg, Amit; Kundu, Roopal V.; Plotkin, Olga; Aronson, Iris K.

doi:10.1001/archderm.142.4.532

Cited by 30 publications

(24 citation statements)

References 5 publications

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“…15 Boussault and colleagues 50 explained this condition as a kind of immune response against a tumor antigen. In 2 of these cases the treatment of the malignancy was followed by the regression of the EAGCG, 49,50 and in 1 of the cases there was a relapse of the granuloma when the leukemia recurred. 49 The coexistence of elastolytic granuloma and leukemia infiltration in the same skin lesions or development in preexisting lymphomatous lesions has been documented.…”

Section: Systemic Associationsmentioning

confidence: 99%

“…In 2 of these cases the treatment of the malignancy was followed by the regression of the EAGCG, 49,50 and in 1 of the cases there was a relapse of the granuloma when the leukemia recurred. 49 The coexistence of elastolytic granuloma and leukemia infiltration in the same skin lesions or development in preexisting lymphomatous lesions has been documented. 51,52 Monoclonal gammopathy of unknown significance has also been related to EAGCG.…”

Section: Systemic Associationsmentioning

confidence: 99%

See 1 more Smart Citation

Elastolytic Actinic Giant Cell Granuloma

Gutiérrez‐González

Pereiro

Toribio

2015

Dermatologic Clinics

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Section: Systemic Associationsmentioning

confidence: 99%

Section: Systemic Associationsmentioning

confidence: 99%

Elastolytic Actinic Giant Cell Granuloma

Gutiérrez‐González

Pereiro

Toribio

2015

Dermatologic Clinics

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“…[23] A particularly interesting case report described a patient in whom AEGCG lesions heralded the onset and recurrence of acute myelogenous leukemia. [24] Therefore, the clinically similar AEGCG lesions should also prompt an appropriate investigation for underlying malignancy.…”

Section: Is Granuloma Annulare Associated With Hematopoietic and Solimentioning

confidence: 99%

Non-Infectious Granulomatous Diseases of the Skin and their Associated Systemic Diseases

Hawryluk

Izikson

English

2010

American Journal of Clinical Dermatology

109

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Non-infectious granulomatous diseases of the skin are a broad group of distinct reactive inflammatory conditions that share important similarities. As a group, they are relatively difficult to diagnose and distinguish both clinically as well as histologically. Many of these disorders have significant associations with systemic diseases that impact the patient's overall prognosis. In this update, we offer a discussion of emerging concepts and controversies in this field, as presented through evidence-based answers to seven important clinical questions regarding palisading and epithelioid granulomata. These questions offer an opportunity to review ten non-infectious granulomatous conditions that have implications for systemic disease: granuloma annulare, annular elastolytic giant cell granuloma, necrobiosis lipoidica, methotrexate-induced accelerated rheumatoid nodulosis, necrobiotic xanthogranuloma, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, palisaded neutrophilic granulomatous dermatitis, sarcoidosis, and metastatic Crohn disease. Recent clinical, epidemiologic, and laboratory studies have shed some light on these diseases, the association of these conditions with systemic disorders, and their overall prognoses.

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“…Kawakami et al 14 described a 70-year-old man with a 3-month history of "GA-like" lesions on his arms; on further workup, he was found to have underlying adult T-cell leukemia. Another report described a 57-year-old man with a 9-month history of a pruritic eruption that was found to be annular elastolytic giant cell granuloma 13 ; further workup revealed underlying AML. Hinckley et al 6 reported 2 cases in which GA was the presenting feature of chronic myelomonocytic leukemia.…”

Section: 10mentioning

confidence: 99%