Annual report of the esophageal cancer radiation group of the Department of Radiotherapy, Tianjin Medical University Cancer Institute &amp; Hospital

Pang, Qingsong; Wei, Xuedong; Zhang, Wencheng; Zhang, Tian; Chen, Xi; Dong, Jie; Wei, Hui; Er, Puchun; Zhao, Jingjing; Han, Dong; Guo, Zhoubo; Lei, Tongda; Du, Qingwu; Guan, Yihui; Wang, Jing; Zhao, Lujun; Wang, Jun; Song, Yi; Liu, Ningbo; Wang, Ping

doi:10.21037/atm-20-4064

Cited by 1 publication

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[7] However, lowdose radiation may be insufficient to eradicate cancer cells and lead to treatment failure, such as uncontrollable tumor progression and tumor relapse. [7,8] To maximize the anti-tumor effect of radiation while minimizing the exposure of healthy tissues, a series of therapeutic techniques have been developed, such as brachytherapy and intensity modulated radiation therapy. [9,10] Nevertheless, these methods mainly focused on accurately positioning the target area rather than improving the radiation efficiency intrinsically.…”

Section: Introductionmentioning

confidence: 99%

Acid‐Responsive Aggregated Gold Nanoparticles for Radiosensitization and Synergistic Chemoradiotherapy in the Treatment of Esophageal Cancer

Luan

Xie

Yang

et al. 2022

Small

View full text Add to dashboard Cite

Radiotherapy and chemotherapy are limited by insufficient therapeutic efficacy of low‐dose radiation and nonspecific drug biodistribution. Herein, an acid‐responsive aggregated nanosystem (AuNPs‐D‐P‐DA) loaded with doxorubicin (DOX) is designed for radiosensitization and synergistic chemoradiotherapy. In response to the acid microenvironment of esophageal cancer (EC), small‐sized AuNPs‐D‐P‐DA forms large‐sized gold nanoparticle (AuNPs) aggregates in tumor tissues to hinder the backflow of AuNPs to the circulation, resulting in enhanced tumor accumulation and retention. Simultaneously, the AuNPs‐based radiosensitization is significantly improved because of the high concentration and large size of intratumoral AuNPs, while DOX are delivered and released specifically into tumor cells triggered by the acid microenvironment for chemo‐radio synergistic therapy. Acid‐responsive AuNPs exacerbate radiation‐induced DNA damage, cell apoptosis, cell cycle arrest, and low colony formation ability in vitro and enhance anti‐tumor efficacy in vivo compared to un‐responsive control. When combined with acid‐responsive DOX, the therapeutic efficacy of the formulation is further improved by their synergistic effect. After the treatment of acid‐responsive AuNPs plus radiotherapy, fatty acid metabolism is reprogrammed in xenograft models, which provides potential targets for further improvement of radiosensitization. In summary, the acid‐responsive AuNPs‐D‐P‐DA nanosystem leverages the radio‐ and chemotherapeutic synergies of AuNPs‐sensitized X‐ray irradiation and acid‐responsive DOX in the treatment of EC.

show abstract