volume 107, issue 5, P2123-2130 2006
DOI: 10.1182/blood-2005-08-3099
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Abstract: IntroductionThe process of leukocyte extravasation is crucial to host survival, such that following application of an inflammatory or infectious stimulus, a coordinated series of cellular and vascular responses is set in train: in this scenario, the blood-borne polymorphonuclear leukocyte (PMN) represents the first line of defense in innate immunity as it is the first cell type to rapidly extravasate. 1 PMN trafficking is tightly regulated, such that proinflammatory and anti-inflammatory mediators operate in …

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