Anisocytosis is associated with myocardial fibrosis and exercise capacity in heart failure with preserved ejection fraction

Rana, Mowadat Hussain; Al-Furaih, Nawaf; Dalton, Jarrod E.; Zidar, David A.; Al‐Kindi, Sadeer G.

doi:10.1016/j.hrtlng.2022.03.013

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…RDW‐SD is calculated from the diameter‐of‐erythrocyte distribution curve at 20% above baseline and is expressed in femtolitres [ 22 , 23 , 24 ]. Originally, RDW was used to evaluate anisocytosis of red blood cells and to differentiate causes of anemia [ 25 , 26 , 27 , 28 , 29 ]. Recently, however, RDW has been employed in various clinical fields.…”

Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width is a useful biomarker to predict bleeding and thrombosis risks in patients with immune thrombocytopenic purpura

Nakamura,

Tsunemine,

Ikunari

et al. 2024

eJHaem

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Bleeding and thrombosis are common complications during immune thrombocytopenic purpura (ITP) treatment. There is a strong need to predict bleeding and thrombosis risks before ITP treatment to optimize therapy and appropriately manage these complications. We performed a retrospective cohort study of 120 patients with primary ITP to identify a biomarker to predict bleeding and thrombosis. We compared blood test results at diagnosis between patients with and without bleeding or thrombosis episodes. The standard deviation of red blood cell distribution width (RDW‐SD) differed significantly between those with and without bleeding and between those with and without thrombosis, leading us to identify it as a variable representative of risk. RDW‐SD was significantly associated with patient age and with histories of several vascular diseases. Multivariate regression analyses showed that RDW integrated several variables associated with vascular risks. RDW‐SD was significantly associated with difficulty with corticosteroid discontinuation (hazard ratio [HR], 2.22, p = 0.01), incidence of bleeding (HR, 2.75, p< 0.01), incidence of thrombosis (HR, 2.67, p< 0.01) and incidence of infection (HR, 1.78, p = 0.04). The RDW‐SD value at the time of ITP diagnosis is a useful biomarker to predict the risks of bleeding, thrombosis, and other complications.

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Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width is a useful biomarker to predict bleeding and thrombosis risks in patients with immune thrombocytopenic purpura

Nakamura,

Tsunemine,

Ikunari

et al. 2024

eJHaem

View full text Add to dashboard Cite

show abstract

“…The coefficient of variation of erythrocyte volume histogram is expressed in % [31][32][33]. Originally, RDW was used to evaluate anisocytosis of red blood cells and to differentiate causes of anemia [34][35][36][37][38]. Recently, however, RDW has been employed in various clinical fields.…”

Section: Discussionmentioning

confidence: 99%

Utilizing red blood cell distribution width (RDW) as a reliable biomarker to predict treatment effects after chimeric antigen receptor T cell therapy

Nakamura,

Jo,

Arai

et al. 2024

Clin Exp Med

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Chimeric antigen receptor T cell (CAR-T) therapy is an effective treatment for B cell malignancies. A certain fraction of patients, however, experience post-CAR-T relapse, and due to the difficulty of precise relapse prediction, biomarkers that can predict the strength and duration of CAR-T efficacy are needed before CAR-T infusion. Therefore, we performed a single-center cohort study including 91 diffuse large B cell lymphoma (DLBCL) patients treated with CAR-T in order to identify such a new prognostic biomarker. After confirming that each of the already reported prognostic parameters (disease status at leukapheresis, primary refractoriness, number of treatment lines, CD3+ cell counts at leukapheresis) has only limited predictive performance, we established a new composite parameter by integrating these four variables, and found that it predicts progression-free survival (PFS) after CAR-T infusion with statistical significance. Moreover, after comprehensive correlation analyses of this new composite parameter with all individual laboratory variables, we determined that the standard deviation of red blood cell distribution width (RDW-SD) at leukapheresis shows significant correlation with the composite parameter and may be a prognostic biomarker (R2 = 0.76, p = 0.02). Validation analysis indicated that a higher RDW-SD is significantly associated with poorer PFS after CAR-T cell therapy (HR, 3.46, P = 0.03). Thus, this study suggests that a single parameter, RDW-SD at leukapheresis, is a novel, useful biomarker that can be obtained early to predict therapeutic effects of CAR-T cell therapy. Post-CAR-T maintenance or re-induction therapies should be adopted for higher risk patients, who may relapse after CAR-T therapy.

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“…Metaanalysis of cohort studies also indi cates that RDW on admission, RDW at discharge, and its change after treatment of HF show prognostic significance in longterm mortality [36]. RDW links to pathophysiology in HF patients, i.e., Bevan et al explained the role of RDW as a prognostic indicator in HF patients by the relationship between the higher RDW and myocardial fibrosis as well as lower exercise capacity estimated by peak oxygen con sumption [37]. The higher RDW in HF patients is associ ated with decompensated hemodynamics such as impaired contractility and elevated enddiastolic pressure of left ven tricle [38,39].…”

Section: Rdw In Heart Failurementioning

confidence: 99%

Red cell distribution width in cardiac diseases: Role of hemorheology and chronic inflammation

Maruyama,

Nakashima

2023

J Biorheol

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Red cell distribution width (RDW) is a simple, inexpensive, and unique laboratory parameter. This hemato logic parameter reflecting the heterogeneity of red cell size was used conventionally to differentiate anemic diseases but is used currently as a prognostic marker of common as well as cardiac diseases. Higher RDW is associated with lower therapeutic response in patients with acute myo cardial infarction undergoing percutaneous coronary inter vention, those with atrial fibrillation undergoing catheter ablation, and those with heart failure under drug therapy. RDW showing such wide usefulness is linked to the chronic inflammation, which dysregulates normal erythropoiesis and impairs deformability of red cells within the micro circulation. Disturbed microcirculation causes persistent and systemic tissue hypoxiareoxygenation insult impairing redox homeostasis, which induces chronic inflammation and clonal hematopoiesis of intermediate potential as a stress memory. Therefore, higher RDW is sustained in many cardiac diseases by hemorheological insult causing chronic inflammation under the clonal expansion of eryth roid cells leading to the reduced deformability and increased RDW of red cells by unknown mechanisms.

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Anisocytosis is associated with myocardial fibrosis and exercise capacity in heart failure with preserved ejection fraction

Cited by 4 publications

References 15 publications

Red blood cell distribution width is a useful biomarker to predict bleeding and thrombosis risks in patients with immune thrombocytopenic purpura

Red blood cell distribution width is a useful biomarker to predict bleeding and thrombosis risks in patients with immune thrombocytopenic purpura

Utilizing red blood cell distribution width (RDW) as a reliable biomarker to predict treatment effects after chimeric antigen receptor T cell therapy

Red cell distribution width in cardiac diseases: Role of hemorheology and chronic inflammation

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