Animal models of tuberculosis

Gupta, Umesh Datta; Katoch, Vishwa Mohan

doi:10.1016/j.tube.2005.08.008

Cited by 141 publications

(121 citation statements)

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“…As demonstrated earlier, the lungs and respiratory tract of guinea pigs closely resemble those of humans; in fact, of all available rodent models, guinea pigs most closely resemble the respiratory tract of primates. 47,48 Guinea pigs are available in ample supply and, compared with NHPs, can be purchased and housed in a cost-efficient manner. On necropsy, the lungs of guinea pigs are of considerable size and permit assessments of gross anatomy and histopathologic analysis of lung tissue, mediastinal lymph nodes, pleural involvement, spleen, and blood dissemination.…”

Section: Discussionmentioning

confidence: 99%

Plague in Guinea Pigs and Its Prevention by Subunit Vaccines

Quenee

Ciletti

Berube

et al. 2011

The American Journal of Pathology

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Human pneumonic plague is a devastating and transmissible disease for which a Food and Drug Administration-approved vaccine is not available. Suitable animal models may be adopted as a surrogate for human plague to fulfill regulatory requirements for vaccine efficacy testing. To develop an alternative to pneumonic plague in nonhuman primates, we explored guinea pigs as a model system. On intranasal instillation of a fully virulent strain, Yersinia pestis CO92, guinea pigs developed lethal lung infections with hemorrhagic necrosis, massive bacterial replication in the respiratory system, and blood-borne dissemination to other organ systems. Expression of the Y. pestis F1 capsule was not required for the development of pulmonary infection; however, the capsule seemed to be important for the establishment of bubonic plague. The mean lethal dose (MLD) for pneumonic plague in guinea pigs was estimated to be 1000 colony-forming units. Immunization of guinea pigs with the recombinant forms of LcrV, a protein that resides at the tip of Yersinia type III secretion needles, or F1 capsule generated robust humoral immune responses. Whereas LcrV immunization resulted in partial protection against pneumonic plague challenge with 250 MLD Y. pestis CO92, immunization with recombinant F1 did not. rV10, a vaccine variant lacking LcrV residues 271-300, elicited protection against pneumonic plague, which seemed to be based on conformational antibodies directed against LcrV.

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Section: Discussionmentioning

confidence: 99%

Plague in Guinea Pigs and Its Prevention by Subunit Vaccines

Quenee

Ciletti

Berube

et al. 2011

The American Journal of Pathology

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“…Estos involucran ratones, cobayos, conejos y primates no humanos cada uno de los cuales presenta sus propias ventajas y limitaciones (Gupta y Katoch, 2005;Borrero et al, 2011).…”

Section: Fase De Descubrimientounclassified

Search for synthetic and natural substances with in vitro bioactivity against Mycobacterium tuberculosis. Part I

Moreno¹,

Ribón²

2017

JOSHA

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“…Although Robert Koch had first infected mice with tubercle bacilli, he used guinea pigs to establish bacteria as the etiologic agent that causes tuberculosis [1]. The remarkable similarities between humans and guinea pigs in many physiological traits have been outlined by several authors [2] and [3], and continue to give reason to use guinea pigs as the preferred model for various diseases and pathological conditions affecting humans, even if mouse or rat models for the same subject of research exist.…”

Section: Introductionmentioning

confidence: 99%

“…Considering susceptibility to certain diseases, disease progression, and the immune response in infected mice however, alternative models using guinea pigs, rabbits, rats, and even non-mammalian species may turn out more suitable than mice to study a certain condition [4]. Most of these alternative models however suffer from a lack of genetically defined strains and absence of the research tools listed above.…”

Section: Introductionmentioning

confidence: 99%