Abstract:More than 65 loci, encoding up to 500 different genes,
have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D).
Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, for example,
those responsible for neonatal or maturity-onset diabetes of the young, only a few of those identified by GWAS, notably
TCF7L2 and ZnT8/SLC30A8, have to date been examined in mouse mod…
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