volume 10, issue 8, P1884-1901 2018
DOI: 10.18632/aging.101510
View full text
Yi-Fan Lian, Yan-Lin Huang, Jia-Liang Wang, Mei-Hai Deng, Tian-Liang Xia, Mu-Sheng Zeng, Min-Shan Chen, Hong-Bo Wang, Yue-Hua Huang

Abstract: Anillin (ANLN) is an actin-binding protein essential for assembly of cleavage furrow during cytokinesis. Although reportedly overexpressed in various human cancers, its role in hepatocellular carcinoma (HCC) is unclear. To address this issue, we confirmed that in 436 liver samples obtained from surgically removed HCC tissues, higher ANLN expression was detected in tumor tissues than in adjacent non-tumor tissues of HCC as measured by immunohistochemistry, quantitative real-time PCR and western blotting. Correl…

expand abstract