volume 29, issue 1, P39-49 2012
DOI: 10.3233/jad-2012-111772
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Hadassa M. Jochemsen, Mirjam I. Geerlings, Anne M. Grool, Koen L. Vincken, Willem PTM. Mali, Yolanda van der Graaf, Majon Muller

Abstract: High levels of angiotensin-converting-enzyme (ACE) may increase the risk of dementia through blood pressure elevation and subsequent development of cerebral small-vessel disease. However, high ACE levels may also decrease this risk through amyloid degradation which prevents brain atrophy. Within the SMART-MR study, a prospective cohort study among patients with symptomatic atherosclerotic disease, serum ACE levels were measured at baseline and a 1.5 Tesla brain MRI was performed at baseline and after on averag…

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