Angiotensin-(1–7) in human follicular fluid correlates with oocyte maturation

Cavallo, Ines Katerina Damasceno; Cruz, Cynthia Dela; Oliveira, Marilene; Puerto, Helen L. Del; Dias, Júlia A; Lobach, Veronica N. M.; Casalechi, Maíra; Camargos, Maria G.R.; Reis, Adelina Martha dos; Santos, Robson A.S.; Reis, Fernando M.

doi:10.1093/humrep/dex072

Cited by 42 publications

(31 citation statements)

References 32 publications

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“…A series of immune cytokines have been identified differentially expressed in the FF of PCOS women (6,7). Furthermore, cytokines, growth factors, proteins, metabolites, and microRNAs found in FF have been associated with oocyte competence, while angiotensin-(1-7) levels in human FF have been correlated with oocyte maturation (8,9). Impaired oocyte quality and outcomes of in-vitro fertilization (IVF) in PCOS have been linked to changes in the components of FF, yet the mechanisms have not been fully elucidated (7, 10).…”

Section: Introductionmentioning

confidence: 99%

TMT Based Proteomic Analysis of Human Follicular Fluid From Overweight/Obese and Normal-Weight Patients With Polycystic Ovary Syndrome

Zhang

et al. 2019

Front. Endocrinol.

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Conclusion: In this proteomic study, a panel of proteins were found differentially expressed in the follicular fluid of PCOS. Inflammatory, immunological, and metabolic abnormalities were identified inside the intra-follicular environment, which could be aggravated by obesity. The identified proteins were correlated with follicular growth and may be considered as candidate biomarkers as well as therapeutic targets of PCOS.

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Section: Introductionmentioning

confidence: 99%

TMT Based Proteomic Analysis of Human Follicular Fluid From Overweight/Obese and Normal-Weight Patients With Polycystic Ovary Syndrome

Zhang

et al. 2019

Front. Endocrinol.

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“…Recent studies describe RAS as a complex system arranged on two main axes: one represented by the ACE/ANG II/ANG I receptor, and the other ACE 2/ANG 1-7/MAS receptor (26). The intermediate products ANG 1-7 have been shown to be biologically active, which renders it more difficult to quantify the process and to manage and control this system with appropriate medication (27). This study is, to the best of our knowledge, one of the first studies in our country showing elevated ANG II levels in the follicular fluid collected from OHSS patients.…”

Section: Discussionmentioning

confidence: 99%

ANG II, VEGF in Ovarian Hyperstimulation Syndrome

et al. 2020

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Background and aims. Severe Ovarian Hyperstimulation Syndrome (OHSS) forms with very aggressive clinical evolution are still common, despite prophylactic measures. Besides the Vascular Endothelial Growth Factor (VEGF), there are other angiogenic factors, like Renin-Angiotensin-Aldosterone System (RAS), that might be associated with this disorder. Our study aims to evaluate the role of VEGF and Angiotensin II (ANG II) in the development of early severe OHSS, in high risk patients under prophylactic Cabergoline therapy. Material and Methods. We recruited 192 patients undergoing in vitro fertilization (IVF) procedures with high risk for OHSS development. Out of these, 106 patients with OHSS were enrolled in the study, of which 28 subjects had a severe form of disease (group I), and 78 patients had a mild/ moderate form (group II). We collected blood and follicular fluid from our study participants and determined serum and follicular VEGF and ANG II levels using Enzyme-Linked Immunosorbent Assay (ELISA) technique. Results. Follicular VEGF, ANG II, and serum VEGF levels were significantly higher in group I versus group II. Serum VEGF titers were 645.97 versus 548.62 (p = 0.0008), follicular VEGF titers were 2919.52 versus 1093.68 (p < 0.0001), and follicular ANG II levels were 281.64 versus 65.76 (p < 0.0001). No significant differences have been shown between the two groups for serum ANG II levels. Conclusion. Our study results provide evidence of a OHSS phenotype that is more prone to undergo severe clinical forms of disease, despite treatments with VEGF receptor blockers, and show that ANG II appears to play a major role alongside VEGF, in the development of these severe forms of disease.

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“…also profiled miRNA expression using aortic tissues from 8 AAAD patients and 9 controls, they showed that 33 miRNAs was upregulated and 8 miRNAs was significantly downregulated (>2-fold). However, only the upregulation of miR-21-5p was validated by RT-PCR 35 . Moreover, aberrant upregulated miR-30a and decreased miR-124 was also observed in the aortic tissue of AAAD patients 36 , 37 .…”

Section: Discussionmentioning

confidence: 99%

Characterization of serum miRNAs as molecular biomarkers for acute Stanford type A aortic dissection diagnosis

Wang

Pan

et al. 2017

Sci Rep

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Early and convenient diagnosis is urgently needed for acute Stanford type A aortic dissection (AAAD) patients due to its high mortality within the first 48 hours. Circulating microRNAs (miRNAs) are promising biomarkers of cardiovascular diseases, however, little is known about circulating miRNAs involved in AAAD. Here, the blood serum was sampled from 104 AAAD+ patients and 103 age-matched donors. Initial screening was conducted using the TaqMan Low Density Array followed by RT-qPCR confirmation. According to the two-phase selection and validation process, we found that miR-25, miR-29a and miR-155 were significantly elevated, while miR-26b was markedly decreased in AAAD+ serum samples compared with AAAD− individuals. Most importantly, for individuals with hypertension, which is a major contributor to AAAD, the 4-miRNA panel also showed high accuracy in predicting those who are more likely to develop AAAD. In the blind trial set, the panel correctly classified 93.33% AAAD+ patients and 86.67% controls from the hypertension cohort. Finally, the serum miRNA-based biomarker for early AAAD detection was supported by a retrospective analysis. Taken together, we identify a distinct profile of 4-miRNA that can serve as a noninvasive biomarker for AAAD diagnosis, especially for those with hypertension.

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Angiotensin-(1–7) in human follicular fluid correlates with oocyte maturation

Abstract: Research supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). The authors have nothing to disclose.

Cited by 42 publications

References 32 publications

TMT Based Proteomic Analysis of Human Follicular Fluid From Overweight/Obese and Normal-Weight Patients With Polycystic Ovary Syndrome

TMT Based Proteomic Analysis of Human Follicular Fluid From Overweight/Obese and Normal-Weight Patients With Polycystic Ovary Syndrome

ANG II, VEGF in Ovarian Hyperstimulation Syndrome

Characterization of serum miRNAs as molecular biomarkers for acute Stanford type A aortic dissection diagnosis

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