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“…The intertwined relationship between the ACE/Ang II/AT 1 receptor axis and its counterlever ACE2/Ang-(1–7)/mas-R axis is now buttressed on a firm literature and its clinical impact is beginning to be fully appreciated in terms of the possibility that many cases of essential hypertension, particularly those associated with low renin, may be explained by a genetic or acquired deficiency of ACE2 or Ang-(1–7) activity. Research in this field is extending knowledge of disease processes outside the cardiovascular system as altered function of the ACE2/Ang-(1–7)/mas-R axis is being implicated in the pathology of cancer (Altundag et al, 2006; Menon et al, 2007; Rodgers et al, 2002, 2003, 2006; Soto-Pantoja et al, 2009; Zhou et al, 2009), liver disease (Alfany-Fernandez et al, 2009; Carvalho et al, 2007; Herath et al, 2007, 2009; Lubel et al, 2008, 2009; Pereira et al, 2007), blood disorders (Ellefson et al, 2004; Heringer-Walther et al, 2009; Kucharewicz et al, 2002), and autoimmune diseases (Pignone et al, 2007). …”
Section: Discussionmentioning
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“…The intertwined relationship between the ACE/Ang II/AT 1 receptor axis and its counterlever ACE2/Ang-(1–7)/mas-R axis is now buttressed on a firm literature and its clinical impact is beginning to be fully appreciated in terms of the possibility that many cases of essential hypertension, particularly those associated with low renin, may be explained by a genetic or acquired deficiency of ACE2 or Ang-(1–7) activity. Research in this field is extending knowledge of disease processes outside the cardiovascular system as altered function of the ACE2/Ang-(1–7)/mas-R axis is being implicated in the pathology of cancer (Altundag et al, 2006; Menon et al, 2007; Rodgers et al, 2002, 2003, 2006; Soto-Pantoja et al, 2009; Zhou et al, 2009), liver disease (Alfany-Fernandez et al, 2009; Carvalho et al, 2007; Herath et al, 2007, 2009; Lubel et al, 2008, 2009; Pereira et al, 2007), blood disorders (Ellefson et al, 2004; Heringer-Walther et al, 2009; Kucharewicz et al, 2002), and autoimmune diseases (Pignone et al, 2007). …”
Section: Discussionmentioning