Angiosarcoma of the heart.

Shackell, Melina; Mitko, A; Williams, Peter; Sutton, George C.

doi:10.1136/hrt.41.4.498

Cited by 28 publications

(8 citation statements)

References 12 publications

(21 reference statements)

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“…1 Most malignant cardiac tumors are angiosarcomas. 2 Leiomyosarcomas are extremely rare primary cardiac tumors. 3 We report herein the case of a primary cardiac leiomyosarcoma.…”

Section: Introductionmentioning

confidence: 99%

Rapidly Growing Primary Cardiac Leiomyosarcoma: Report of a Case

et al. 2000

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Primary cardiac leiomyosarcomas are very rare. A 19-year-old man was admitted to a local hospital with dyspnea and hemoptysis. He was later transferred to our hospital because of his worsening dyspnea. An enhanced chest computed tomography scan demonstrated a large mass in the left atrium. A transthoracic echocardiogram showed a large mobile mass in the left atrium. The tumor was totally resected. The pathohistological examination showed leiomyosarcoma. The tumor rapidly recurred. and a second and third operation were performed. After the third operation, the patient was treated with radiotherapy. There was no local recurrence but multiple distant metastases were found 2 months after completion of radiation therapy.

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“…1 Most malignant cardiac tumors are angiosarcomas. 2 Leiomyosarcomas are extremely rare primary cardiac tumors. 3 We report herein the case of a primary cardiac leiomyosarcoma.…”

Section: Introductionmentioning

confidence: 99%

Rapidly Growing Primary Cardiac Leiomyosarcoma: Report of a Case

et al. 2000

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“…Previous studies demonstrated the rapid growth of angiosarcoma, resulting in poor prognosis [4,5]. Rapid and accurate assessment of tumor location and its relationship to adjacent structures is therefore essential to consider the indication of medical or invasive care.…”

Section: Discussionmentioning

confidence: 99%

A case of right atrial tumor diagnosed by cardiac computed tomography

Okuyama

Fukuda

Ehara

et al. 2010

Journal of Cardiology Cases

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A 60-year-old woman was admitted with chief complaints of dyspnea for the previous 3 weeks. Transthoracic echocardiography (TTE) showed the amount of pericardial effusion and signs of cardiac tamponade. However, a tumor was not detected by TTE in any view. Multidetector computed tomography (MDCT) showed that the tumor protruded into the right atrium, invading to the outside of the heart. Transesophageal echocardiography (TEE) also showed the mobile tumor in the right atrium. In conclusion, this report may demonstrate that MDCT and TEE are required as complementary methods in the detection of cardiac tumors.

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“…Cytologic results of effusions in patients with advanced angiosarcoma can be negative, even after repeated testing. 5 The differential diagnosis of a nodular mass in the pericardium includes metastatic tumor, soft-tissue sarcoma, rhabdomyosarcoma, melanoma, mesothelioma, and Kaposi sarcoma. The criteria by which a tumor is considered a post-irradiation sarcoma were originally proposed by Cahan and colleagues 6 and were subsequently revised by Murray and associates.…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma Causing Cardiac Constriction Late after Radiation Therapy for Breast Carcinoma

Sharma¹,

DeValeria²,

Scherber³

et al. 2016

Texas Heart Institute Journal

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P ericardial constriction remains a difficult diagnosis that requires a high degree of clinical suspicion, careful clinical examination, and multimodality imaging. The cause of the constriction can be challenging to ascertain and often becomes evident only at the time of surgical resection. Such is the case we present.Primary tumors of the pericardium are extremely rare, with an incidence of between 0.001% and 0.28% in an autopsy study 1 ; approximately 8% of those are angiosarcoma. In a study by Kirova and colleagues 2 of 16,705 patients who received radiation therapy (RT) for breast cancer, only 13 patients developed angiosarcoma of the breast, chest wall, or skin after a median follow-up period of 9.3 years. Pericardial angiosarcoma after RT is rare but has been described.1 To our knowledge, this is the 2nd report of angiosarcoma of the pericardium after RT. Case ReportA 41-year-old woman presented with 8 weeks of progressive dyspnea, orthopnea, and cough. Her history included intracystic papillary carcinoma of the left breast 8 years earlier (treated with lumpectomy and postoperative RT). The details of the protocol and dosage of radiation used during the treatment were not available. The physical examination was consistent with pleural and pericardial effusions. The white cell count was elevated, as were the serum creatinine level (2 mg/dL [normal range, 0.6-1.1 mg/ dL] and the blood urea nitrogen level (46 mg/dL [normal range, 6-21 mg/dL]). Her other laboratory tests-coagulation profile, autoimmune/rheumatologic disease assay, and urinalysis-were within normal limits. A chest radiograph revealed bilateral pleural effusions. Computed tomography (Fig. 1) revealed a large amount of pericardial fluid extending to the aortic root, with an increased density suggesting hemorrhage or high protein content and a possible anterior mass over the right atrium, thought to represent an ill-defined mass or organized hematoma and pleural effusions.Transthoracic echocardiography revealed preserved left ventricular ejection fraction, diastolic dysfunction, bilateral pleural effusions, and evidence of effusive-constrictive pericarditis. Thoracocentesis and pericardiocentesis through a pericardial window revealed no malignant cells. Laboratory evaluation of the effusions for autoimmune and rheumatologic disease was negative.The patient underwent open-chest pericardiectomy for constrictive pericarditis. On the visceral pericardium, there were nodular masses-7-mm thick, rubbery, and dark red-brown-adherent to the parietal pericardium.Microscopically, these were spindle-cell neoplastic cells with marked nuclear pleomorphism, consistent with angiosarcoma (Fig. 2). The malignant cells expressed vimentin, factor VIII, podoplanin, and CD31, with focal expression of CD34. The

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Angiosarcoma of the heart.

Cited by 28 publications

References 12 publications

Rapidly Growing Primary Cardiac Leiomyosarcoma: Report of a Case

Rapidly Growing Primary Cardiac Leiomyosarcoma: Report of a Case

A case of right atrial tumor diagnosed by cardiac computed tomography

Angiosarcoma Causing Cardiac Constriction Late after Radiation Therapy for Breast Carcinoma

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