Angiosarcoma of the breast

Vorburger, Stephan A.; Xing, Yan; Hunt, Kelly K.; Lakin, Gregory E.; Benjamin, Robert S.; Feig, Barry W.; Pisters, Peter W.T.; Ballo, Matthew T.; Chen, Lei; Trent, Jonathan C.; Burgess, M. A.; Patel, Shreyaskumar; Pollock, Raphael E.; Cormier, Janice N.

doi:10.1002/cncr.21531

Cited by 198 publications

(185 citation statements)

References 32 publications

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“…The tumor diameter is the most important prognostic factor. The five-year survival rate is 70% if the tumor diameter is less than 5 cm, but only 35% if the tumor diameter is more than 5 cm, with no significant effect from tumor grade on survival rate [12].…”

Section: Discussionmentioning

confidence: 96%

Angiosarcoma of the Breast with Silicone Granuloma: A Case Report

Takenaka¹,

Tanaka²,

Isobe³

et al. 2009

Kurume Med. J.

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Summary:Angiosarcoma of the breast is a rare non-epithelial tumor and that accounts for less than 0.1% of primary malignancies of the breast. The disease has a relatively higher occurrence among young people, and its prognosis (3-year-survival of only 38%) is extremely poor compared to breast cancer. Here we present a case of an 87-year-old woman who had undergone bilateral breast augmentation with silicone injections in her youth. Although she became aware of a tumor in her right breast, she waited 8 years before seeking treatment. She felt the tumor growing and experienced swelling and pain, but she ended up declining therapy at that time. Two years later she was brought to our hospital by ambulance for continuous bleeding from the same tumor of the breast, which by that time was over 11 cm in diameter. We performed emergency mastectomy. The histological diagnosis was angiosarcoma of the breast with silicone granuloma.

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Section: Discussionmentioning

confidence: 96%

Angiosarcoma of the Breast with Silicone Granuloma: A Case Report

Takenaka¹,

Tanaka²,

Isobe³

et al. 2009

Kurume Med. J.

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“…Multiple other factors have sporadically been shown to affect prognosis, including grade and margin status, although the size of previous studies has made the drawing of definitive conclusions difficult. The major aetiological factor that is implicated in the development of breast sarcoma is previous irradiation of the breast after treatment for a prior malignancy [8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Treatment for breast sarcoma: A large, single-centre series

Pencavel

Allan

Thomas

et al. 2011

European Journal of Surgical Oncology (EJSO)

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Please cite this article as: Pencavel T, Allan CP, Thomas M, Hayes A. Treatment for breast sarcoma: a large, single-centre series., European Journal of Surgical Oncology (2011Oncology ( ), doi: 10.1016Oncology ( / j.ejso.2011 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Breast sarcoma. Conflict of Interest:The authors are not aware of any competing or conflicting interest in the preparation of this manuscript. Synopsis:Breast sarcoma is a rare condition. This large series evaluates prognostic factors from the standpoint of a large tertiary referral centre. Previous breast irradiation emerges as the factor most strongly associated with poorer prognosis; other factors are also discussed. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT AbstractBackground

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“…8 The median latency period ranges from 59 to 103 months in the literature, which is in line with our data. 8,[24][25][26][27][28] RAS may be of any type, but angiosarcoma was the most common in our patient group and in other series of thoracic RAS. [2][3][4]19,22 Angiosarcoma may be associated with chronic lymphedema of a limb or of the chest wall (Stewart-Treves [ST] syndrome), which is diagnosed most frequently after axillary lymph node dissection as a part of breast cancer treatment and can occur in the lymphedematous arm itself or in the shoulder, axillary, or chest wall region.…”

Section: Discussionmentioning

confidence: 55%

Reirradiation and hyperthermia for radiation‐associated sarcoma

Jong

Oldenborg

Oei

et al. 2011

Cancer

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BACKGROUND:The objective of this study was to evaluate the role of reirradiation and hyperthermia in the treatment of radiation-associated sarcoma (RAS) in the thoracic region, which is an increasing, yet extremely rare condition with a poor prognosis. METHODS: Between 1979 and 2009, 16 patients with RAS in the thoracic region were treated in the Academic Medical Center and the Institute Verbeeten with reirradiation and hyperthermia. In 13 patients, this treatment was given for unresectable disease and 3 times after resection as adjuvant treatment. The median latency period between the original malignancy diagnosis and the RAS diagnosis was 86 months (range 19-212 months). Histology was angiosarcoma in 11 patients (69%). The literature on reirradiation with or without hyperthermia for RAS was reviewed. RESULTS: The median survival was 15.5 months (range, 3-204 months). Four patients were not evaluable for response. The response rate for the remaining 12 patients was 75% (7 complete responses and 2 partial responses). Six patients remained free of local failure until death (5 months and 7 months) or last follow-up (8 months, 11 months, 39 months, and 68 months). CONCLUSIONS: The current study indicates that combined reirradiation and hyperthermia for RAS in the thoracic region is feasible. The high response rate and the possibility of durable local control suggest that this treatment is promising. Cancer 2012;118:180-

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Angiosarcoma of the breast

Cited by 198 publications

References 32 publications

Angiosarcoma of the Breast with Silicone Granuloma: A Case Report

Angiosarcoma of the Breast with Silicone Granuloma: A Case Report

Treatment for breast sarcoma: A large, single-centre series

Reirradiation and hyperthermia for radiation‐associated sarcoma

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