Angiosarcoma of the adrenal gland

Kędzierski, Leszek; Hawrot-Kawecka, Anna; Holecki, Michał; Duława, Jan

doi:10.20452/pamw.1899

Cited by 5 publications

(5 citation statements)

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“…Angiosarcomas are very rare, malignant vascular tumors with high mortality rates (3,4). Primary adrenal angiosarcoma is an especially rare entity that was first described by Kareti et al (5) in 1988.…”

Section: Discussionmentioning

confidence: 99%

“…Also, administration of radiation therapy in the past or previous abdominal traumas has no correlation with adrenal angiosarcoma (1). In most cases, adrenal angiosarcomas are diagnosed coincidentally following routine workup for patient complaints, which are generally non-specific abdominal discomfort or pain (2,3). In this report, we present a new case of adrenal gland angiosarcoma of unusual size, which will enrich the collected scientific data on this very rare clinical entity.…”

Section: Introductionmentioning

confidence: 86%

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Adrenal angiosarcoma

et al. 2018

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Adrenal angiosarcoma is an uncommon neoplasm that derives from the vascular endothelium; due to its biological behavior, it should be distinguished from other adrenal tumors. We herein report a case of a 57-year-old woman with diagnosis of an adrenal tumor that was suspected to be malignant. The specimen was histopathologically proved to be an angiosarcoma. The patient was suffering from right upper quadrant pain; after laboratory and radiological workup, a non-functioning right adrenal mass, 14 cm in size, was recognized. A right subcostal incision was made, and adrenalectomy was performed successfully with tumor-free surgical margins. Two months after the operation, a positron emission tomography-computed tomography scan was ordered for follow-up. No tumor tissue or any other metastatic foci remained. The patient had been referred to our medical oncology department and underwent retroperitoneal radiotherapy. However, unfortunately, the patient died due to cardiac insufficiency during the follow-up period.Keywords: Adrenal angiosarcoma, adrenal gland, malignant vascular tumors, adrenal incidentaloma INTRODUCTIONAdrenal angiosarcomas are infrequently encountered neoplasms in daily practice; therefore, they are not well documented in the literature. The etiological factors of this neoplasm are still not clearly understood; however, in a case report, exposure to some carcinogens was believed to be the cause of an adrenal angiosarcoma. There is no evidence supporting the relationship between primary adrenal angiosarcoma and multiple neuroendocrine tumors. Also, administration of radiation therapy in the past or previous abdominal traumas has no correlation with adrenal angiosarcoma (1). In most cases, adrenal angiosarcomas are diagnosed coincidentally following routine workup for patient complaints, which are generally non-specific abdominal discomfort or pain (2, 3). In this report, we present a new case of adrenal gland angiosarcoma of unusual size, which will enrich the collected scientific data on this very rare clinical entity. CASE PRESENTATIONA 57-year-old female patient with right upper abdominal pain was admitted to our hospital. Her past medical history included hypertension and hypercholesterolemia, which were under control. On physical examination, slight tenderness was found in the right upper quadrant, without any rebound or Murphy's sign. Cholecystitis was one of our differential diagnoses; therefore, the patient underwent abdominal ultrasound (US). Multiple gallstones were detected; however, significantly, a 14-cm abdominal lesion was also recognized beneath the liver. Therefore, computed tomography (CT) scans of the abdomen (Figure 1) and chest were ordered. A heterogeneous mass 14×12 cm in diameter, originating from the right adrenal gland, was revealed without contrast dying. There were no additional metastatic disseminations. Blood and urinary analyses documented no hormonal activity of the tumor. Preoperative LDH measurement was 422 U/L, VMA was 1.93 mg/day, normetanephrine was 255.5 µg/24 h, m...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 86%

Adrenal angiosarcoma

et al. 2018

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“…Patients present in a variety of ways including flank or abdominal pain, palpable mass, fatigue, weight loss, fever, or clinically asymptomatic with a mass detected on incidental imaging. Table 1 summarizes the age, sex, type of presentation, treatment, and follow-up for previously reported cases 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27. Patients who present with systemic symptoms tend to have worse outcomes than those with localized symptomatology.…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma of the Adrenal Gland Treated Using a Multimodal Approach

Fuletra

Ristau

Milestone

et al. 2017

Urology Case Reports

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Angiosarcoma of the adrenal gland is an extremely rare malignancy. We report a case of a 59-year-old female who presented with abdominal pain and profound anemia. A 7 cm enhancing, lipid-poor adrenal mass with calcifications that extended posterior to the vena cava was identified on imaging. Patient underwent right adrenalectomy with retroperitoneal lymph node dissection. Pathology demonstrated angiosarcoma of the adrenal gland. Consolidative treatment included adjuvant radiation and chemotherapy. Patient remains disease free 1.5 years following treatment. Prior reported literature on the diagnosis and management of adrenal angiosarcoma is reviewed.

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“…PAA is an extremely rare aggressive neoplasm. The first example of PAA was described by Kareti in 1988 [ 11 – 14 ]. Patients usually present non-specific symptoms like abdominal pain.…”

Section: Discussionmentioning

confidence: 99%

“…Radiation therapy may be not effective [ 12 ]. In the largest series of nine PAA tumors found in literature, thee patients survived, three died from the recurrence of the disease and three died of any other causes [ 13 , 14 ]. Our patient (case four) had recurrence of the disease and died after two years.…”

Section: Discussionmentioning

confidence: 99%

The collection of five interesting cases of adrenal tumors from one medical center

Babińska

Pęksa

Świątkowska−Stodulska

et al. 2014

World J Surg Onc

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IntroductionAdrenal tumors are detected incidentally in 4 to 8% of patients in imaging studies. Adenomas, pheochromocytomas and adrenocortical carcinomas represent the most common tumors of the adrenal glands. Rarely are final histopathological reports are surprising.AimThe aim of our study is a retrospective analysis of selected clinical characteristics and hormonal studies in five cases of rare adrenal tumors.Materials and methodsWe present five interesting cases of adrenal tumors: two medullary hyperplasia, one adenomatoid tumor, one hydatid cyst and a primary angiosarcoma of the adrenal gland. The final diagnosis was established by means of microscopic examination of the specimens.ConclusionsThe number of adrenal tumors was increased due to widespread use of imaging procedures. In patients without any known extra-adrenal malignancy most lesions are benign, non-hyper functioning adenomas. Adrenal tumors should be evaluated biochemically and radiologically.

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Angiosarcoma of the adrenal gland

Cited by 5 publications

References 0 publications

Adrenal angiosarcoma

Adrenal angiosarcoma

Angiosarcoma of the Adrenal Gland Treated Using a Multimodal Approach

The collection of five interesting cases of adrenal tumors from one medical center

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