Angiolymphoid Hyperplasia With Eosinophilia Associated With Anomalous Dilatation of Occipital Artery: IL-5 and VEGF Expression of Lesional Mast Cells

Aoki, M.

doi:10.1001/archderm.138.7.982

Cited by 27 publications

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“…Vascular malformation, such as arteriovenous (AV) shunts and thrombi, are found in 42% and 20% of cases, respectively, according to previous studies 8 . Arteritis, dilation of the occipital artery, 14 radial artery aneurysm, and facial artery aneurysm 15 have all been cited as causal. Damage to vessel walls, including fragmented elastic lamina, fibrointimal proliferation, and/or disruption of the muscular wall, has also been reported 15 .…”

Section: Discussionmentioning

confidence: 96%

“…Recently, mast cells present in the infiltrate of an ALHE lesion have been shown to express interleukin‐5 and vascular endothelial growth factor, suggesting that mast cells may have a role in the angiogenic response and eosinophil infiltration of ALHE 14 . The levels of eosinophil cationic protein, released from eosinophil granules, have also been shown to correlate with the clinical course of ALHE 16 …”

Section: Discussionmentioning

confidence: 99%

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Angiolymphoid hyperplasia with eosinophilia induced by trauma

Busquets

Sánchez

2006

Int J Dermatol

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A 48‐year‐old Hispanic man presented to our clinic with multiple, bright red, firm nodules limited to the right side of the scalp (Fig. 1). The patient had first noted a lesion 6 months previously, and complained of mild associated pruritus and ease of bleeding. The first lesion developed at the exact site at which the patient had accidentally hit his head against a filing cabinet 2 years previously. The trauma had been associated with significant bleeding, which required more sutures than expected. In a magnetic resonance image, the initial nodule was visualized and, because of its firm consistency, the diagnosis of a lipoma was made. Surgical excision of the tumor was attempted, but was complicated by significant bleeding, which required extensive electrocoagulation. Shortly thereafter, multiple new lesions slowly began to develop around the original nodule. In addition, the patient complained of new‐onset migraine headaches. 1 Linear arrangement of erythematous nodules on the scalp On physical examination, the right side of the patient's scalp showed multiple, erythematous, firm papules and nodules measuring 0.5–2.5 cm in diameter. These were slightly alopecic, and the largest and earliest tumor was pulsatile. There was no associated lymphadenopathy or peripheral eosinophilia. On angiography, an arteriovenous malformation was detected. Specifically, branches from the occipital arteries bilaterally appeared to feed the malformation (Fig. 2). Skin biopsy of one of the nodules revealed lobular proliferations of capillary‐sized vessels around larger central vessels, with a mild perivascular infiltrate of lymphocytes and eosinophils in the dermis. The larger vessels were lined by characteristic “hobnail” endothelial cells, which protruded into the lumen (Fig. 3). As this vascular anomaly was thought to underlie his skin lesion, the patient was treated with embolization using polyvinyl alcohol particles and fiber coils, which resulted in increased pallor of the lesions, a greater than 50% decrease in size, decreased pulsatility, and resolution of his migraine headaches. Six months after this successful procedure, no new lesions had developed. Presently, the patient is opting to defer further treatment in the hope that the lesions will resolve entirely. A second endovascular treatment with polyvinyl alcohol particles and acrylic glue is pending based on the course of his disease. 2 Dilated and tortuous branches from the right occipital artery feed into an arteriovenous malformation (AVM), with the resultant scalp lesions visible on angiogram (lateral view) 3 Vascular proliferation with well‐formed lumens and cells protruding into them in a hobnail‐like fashion, together with a mixed‐cell inflammatory infiltrate (hematoxylin and eosin, ×200)

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Angiolymphoid hyperplasia with eosinophilia induced by trauma

Busquets

Sánchez

2006

Int J Dermatol

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“…[6]Interleukin 5 and vascular endothelial growth factor were also found to be increased in some cases. [7 ]The subcutaneous lesions associated with ALHE may vary in colour, shape and size. Ranging from red to brown in colour, the lesions may be smooth or centrally eroded with crusting.…”

Section: Discussionmentioning

confidence: 99%

Angiolymphoid Hyperplasia with Eosinophilia- A Case Report in an Elderly Patient

Bajpai¹,

Deepti²

2014

IOSRJDMS

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“…[9] Interleukin 5 and vascular endothelial growth factors were also found to be increased in some cases. [10]…”

Section: Discussionmentioning

confidence: 99%

Angiolymphoid hyperplasia with eosinophilia mimicking multiple cylindromas: a rare case report

et al. 2014

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Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare and idiopathic vascular disorder. It is characterized by red to brown papules and nodules, typically localized on the head and neck, particularly around the ear as singular or multiple lesions. Although ALHE is a benign disease, lesions are often persistent and difficult to eradicate. Young to middle age women are more commonly affected. The histological examination corresponds to a florid vascular proliferation with atypical endothelial cells surrounded by a lymphocytic and eosinophilic infiltrate. We describe an elderly male with multiple nodular lesions over the scalp mimicking cylindromas; the histological examination was consistent with ALHE.

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Angiolymphoid Hyperplasia With Eosinophilia Associated With Anomalous Dilatation of Occipital Artery: IL-5 and VEGF Expression of Lesional Mast Cells

Cited by 27 publications

References 0 publications

Angiolymphoid hyperplasia with eosinophilia induced by trauma

Angiolymphoid hyperplasia with eosinophilia induced by trauma

Angiolymphoid Hyperplasia with Eosinophilia- A Case Report in an Elderly Patient

Angiolymphoid hyperplasia with eosinophilia mimicking multiple cylindromas: a rare case report

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