Angiolymphoid hyperplasia with eosinophilia

Kimura Disease of the Epiglottis

“…The discovery of some cases to be associated with renal glomerular disease in the form of nephrotic syndrome and the demonstration of IgE deposition in the renal glomeruli as well as in the germinal centers of the involved lymph nodes, support the notion that KD is an aberrant immune response i.e. ; autoimmune disorder [1,7,9,11]. In [3].…”

“…Histological differential diagnosis may include ALHE, florid follicular hyperplasia, parasitic/allergic reaction, Castleman disease (CD), Hodgkin lymphoma (HL), and Langerhans histiocytosis (LH) [1,3,11]. KD has certain basic and constant features which can help in confirming the diagnosis and excluding other possibilities (Table 2).…”

“…We feel the most important features are those of the germinal centers. Germinal centers in KD have characteristic features which include: granular to linear deposition of esinophilicpink proteinaceous material, vascularization with infiltration of small blood vessels into the germinal centers, infiltration of esinophils right into the germinal centers with occasional esinophilic microabscess formation with/without esinophilic folliculolysis, and the presence of multinucleated giant cells(polykaryocytes) of the WarthinFinkeldey type within the germinal centers [1,2,6,7,11,12]. A constant feature of KD is the pattern of esinophilic infiltrate.…”

“…A very important histological differential diagnosis and pitfall to be avoided is ALHE. The important and helpful features differentiating KD from ALHE are summarized in (Table 2) [5,[7][8][9][10][11][12]. CD has characteristic ''onion-skin'' layering of the mantle zone with hyalinized blood vessels in the germinal centers.…”

“…However, this observation was based on a single case study and was not validated by subsequent studies [1][2][3]. In addition, no malignant transformation was reported so far to be associated with KD [3,6,11]. Surgical resection is the primary treatment for KD [1,6].…”