Angiographic Quantification of Thrombus in ST‐Elevation Acute Myocardial Infarction Presenting with an Occluded Infarct‐Related Artery and Its Relationship with Results of Percutaneous Intervention

Miranda-Guardiola, Faustino; Rossi, Angélica; Serra, Antonio; García, Bruno; Rumoroso, José Ramón; Íñiguez, Andrés; Vaquerizo, Beatriz; Triano, José Luis; Sierra, Gilberto; Bruguera, Jordi

doi:10.1111/j.1540-8183.2009.00464.x

Cited by 26 publications

(15 citation statements)

References 23 publications

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“…Those which did not provide these features angiographically were defined as grade 0, 1, 2, 3. Finally, we classified patients as a high thrombus burden (grade 4 and 5) and low thrombus burden (grade 0, 1, 2, 3) in our study 17) .…”

Section: Methodsmentioning

confidence: 99%

The Elevated Soluble ST2 Predicts No-Reflow Phenomenon in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Somuncu

Akgün

Çakır

et al. 2019

JAT

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Aim: The primary percutaneous procedure resulted in a significant improvement in the prognosis of myocardial infarction. However, no-reflow phenomenon restrains this benefit of the process. There are studies suggesting that soluble suppression of tumorigenicity (sST2) can be valuable in the diagnosis and progression of heart failure and myocardial infarction. In this study, we aimed to investigate the effect of sST2 on no-reflow phenomenon in ST-elevated myocardial infarction (STEMI).Method: This study included 379 patients (258 men; mean age, 60 ± 11 years) who underwent primary percutaneous treatment for STEMI. sST2 levels were measured from blood samples taken at admission. Patients were divided into two groups according to Thrombolysis in Myocardial Infarction(TIMI) flow grade: group 1 consists of TIMI 0,1,2, accepted as no-reflow, and group 2 consists of TIMI 3, accepted as reflow.Results: No-reflow phenomenon occurred in 60 patients (15.8%). The sST2 level was higher in the no-reflow group (14.2 ± 4.6 vs. 11.3 ± 5.0, p = 0.003). Moreover, regression analysis indicated that diabetes mellitus, lower systolic blood pressure, multivessel vascular disease, high plaque burden, and grade 0 initial TIMI flow rate were other independent predictors of the no-reflow phenomenon in our study. Besides, when the patients were divided into high and low sST2 groups according to the cut-off value from the Receiver operating characteristics analysis, being in the high sST2 group was associated with 2.7 times increased odds for no-reflow than being in the low sST2 group.Conclusion: sST2 is one of the independent predictors of the no-reflow phenomenon in STEMI patients undergoing primary percutaneous coronary intervention.

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Section: Methodsmentioning

confidence: 99%

The Elevated Soluble ST2 Predicts No-Reflow Phenomenon in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Somuncu

Akgün

Çakır

et al. 2019

JAT

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“…As reported previously in de novo lesion STEMI, a high thrombus grade is more often seen with reduced initial TIMI 3 flow and the same finding was observed in this study with ST. Glycoprotein IIb/IIIa inhibitors were administered more often to patients with high thrombus burden, likely due to operator recognition of the requirement for potent and immediate antiplatelet therapy. A large thrombus burden during de novo STEMI treated with PCI is associated with an increased risk of future ST and correlates with worse outcomes . A high thrombus grade during PCI for ST was also previously reported to be associated with recurrent ST .…”

Section: Discussionmentioning

confidence: 77%

Angiographic characteristics of definite stent thrombosis: Role of thrombus grade, collaterals, epicardial coronary flow, and myocardial perfusion

Reeves

Patel

Armstrong

et al. 2014

Cathet Cardio Intervent

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The majority of ST patients present with late/very late ST with high thrombus burden and STEMI. Presence of collateral vessels and low thrombus burden is cardioprotective, while reduced initial TIMI flow is associated with larger infarct size and recurrent ST. Aspiration thrombectomy and repeat stenting are associated with improved epicardial coronary artery flow and myocardial perfusion among patients treated for ST. © 2014 Wiley Periodicals, Inc.

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“…Although proximal location of culprit lesion was higher in OC (+) group, it is unrelated to thrombus grade. Miranda‐Guardiola et al also showed that there is no predictive role for the location of the culprit lesion on the thrombus grade. Thrombus containing lesions are well‐known predictors of complications in P‐PCI because of increased risk of acute vessel closure, no reflow, distal embolization, reinfarction, and stent thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Drospirenone‐Containing Oral Contraceptives and Risk of Adverse Outcomes After Myocardial Infarction

Karabay

Kocabay

Oduncu

et al. 2013

Cathet Cardio Intervent

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This is the first study to evaluate the myocardial infarction risk and its subsequent clinical sequelae in women having a STEMI while taking the OC-Yasmin. Women on the oral contraception Yasmin, who underwent coronary revascularization had a lower post-procedural complete ST resolution and worse left ventricular function. Furthermore, OC use with Yasmin is an independent predictor of a high-grade thrombus burden.

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Angiographic Quantification of Thrombus in ST‐Elevation Acute Myocardial Infarction Presenting with an Occluded Infarct‐Related Artery and Its Relationship with Results of Percutaneous Intervention

Abstract: Only a third of STEMI patients present with an LT, being diabetes and lack of clopidogrel pretreatment independent predictors. An LT is strongly associated with worse PCI results.

Cited by 26 publications

References 23 publications

The Elevated Soluble ST2 Predicts No-Reflow Phenomenon in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

The Elevated Soluble ST2 Predicts No-Reflow Phenomenon in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Angiographic characteristics of definite stent thrombosis: Role of thrombus grade, collaterals, epicardial coronary flow, and myocardial perfusion

Drospirenone‐Containing Oral Contraceptives and Risk of Adverse Outcomes After Myocardial Infarction

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