Angiographic Findings in Postinfarction Patients Under the Age of 35

Burkart, F; Salzmann, C

doi:10.1007/978-3-642-68294-0_9

Cited by 14 publications

(7 citation statements)

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“…8 Angiograms of the left coronary artery in LAO hemiaxial position of a 35.year-old man (above) and a 28-year-old woman (below) 3 months and 4 months, respectively, after anteroseptal myocardial infarction, In both patients, two streaks of contrast medium in the proximal left anterior descending artery are seen, indicating recanalization of a thrombus One-vessel disease is predominant in myocardial infarction at a young age contrary to the myocardial infarction of middle and advanced ages (48,59). Findings of other authors (9,14,25,64,70) confirm this statement. Only onethird of consecutive patients under age 60 showed one-vessel disease (5).…”

Section: Discussionsupporting

confidence: 66%

Myocardial Infarction at a Young Age (Under 40 Years)

Roskamm¹,

Gohlke²,

Stürzenhofecker³

et al. 1984

Int J Sports Med

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Coronary morphology, risk factors, long-term prognosis, and progression of coronary arteriosclerosis were investigated in 679 (649 mean and 30 women) post-infarction patients under 40 years of age. These patients represented 80% of 844 MI patients under 40 who were referred to our hospital in the years 1973-1980; 20% had refused coronary angiography; 465 patients were followed up for 1-7 years (mean 3.5 years). In 164 patients, a second coronary angiography was performed 3.8 years after the first angiogram, which was done an average 3 months after the acute episode. The main results were as follows: 8.4% of the patients had zero-vessel disease and 3.7% had a normal coronary angiogram. The majority had single-vessel disease (57.3%). The prevalence of zero-vessel disease decreased with age while that of multivessel disease increased. With increasing vessel involvement, the prevalence of hypercholesterolemia, hypertriglyceridemia, and hypertension increased. A history of smoking was equally common in patients with zero-, single-, double-, and triple-vessel disease. In women the combination of smoking and the use of oral contraceptive drugs was frequently seen. In one-quarter of the zero-vessel disease patients, the infarction occurred during unusually intense physical exercise. The statistical analysis of the survival data using the proportional hazards model (univariate analysis) showed the variables heart volume/body wt., ventricular arrhythmias, PCP at rest, PCP max, work capacity, ventricular function, and number of diseased vessels to be of prognostic importance. Multivariate analysis using this model revealed the following independent variables to be relevant to prognosis: heart volume/body wt., ventricular arrhythmias, ventricular function, and number of diseased vessels. After an average of 3.8 years since the first coronary angiography, 28.6% of the patients showed a significant progression of coronary arteriosclerosis (at least two degrees of stenosis according to the AHA classification). In the subgroup of patients with multilocular disease in the first angiogram, progression was 10 times as frequent as in a group with initial unilocular disease (34.3% vs 3.6%). Patients with progression had continued to smoke significantly more often than patients without progression (38.4%) vs 14.5%). Regression of coronary angiographic findings was significantly more frequent in the group of patients with initial unilocular disease than in those with multilocular disease in the first angiogram (28.6% vs 10.6%). Regression might be explained as recanalization and organization of a thrombus.(ABSTRACT TRUNCATED AT 400 WORDS)

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Section: Discussionsupporting

confidence: 66%

Myocardial Infarction at a Young Age (Under 40 Years)

Roskamm¹,

Gohlke²,

Stürzenhofecker³

et al. 1984

Int J Sports Med

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“…The present findings of predominantly single-vessel disease in young patients in this study also suggests the same. 10 Moreover, the predominance of angiographic single vessel disease in these young patients as in this study primarily suggest that premature myocardial infarction probably result from a rapid progressive event, such as thrombosis or plaque rupture, rather than a gradually evolving process such as atherosclerosis and thus substantiate the need for an intense and aggressive approach directed towards primary and secondary preventions of premature cardiovascular disease. 11 The management of MI generally is not dependent on age and guideline-suggested therapies are just as applicable to younger patients as they are to their older counterparts.…”

Section: Discussionmentioning

confidence: 50%

Risk factor analysis and angiographic findings in young myocardial infarction patients in tertiary care centre of rural population in South India

2019

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Background: Coronary Artery Disease (CAD) is the leading cause of death and accounts for around 12million deaths annually worldwide. The pattern of coronary artery involvement and clinical outcome varies with age suggesting different underlying pathophysiology. Better understanding this specific problem will lead to further improvement in management. The aim was to study the risk factors and angiographic findings in young patients with acute myocardial infarction. Methods: Thirty-nine patients were included in this study. Patients included in the study underwent elective angiographic performed by the percutaneous femoral approach using standard angiographic techniques. Echo and lipid profile were done to all patients. Data were analysed using MS-Excel. Results: In this study, 39 patients were included, 37 male and 2 female patients, the average age of the patients was 35.12 years. 59% of patients had hypertriglyceridemia, 23.1% of patients hypercholesteremia. 45.9% of male patients were having a history of smoking and alcoholism. 84.6% of patients had obstructive CAD, single vessel disease was observed in 59%, double vessel disease in 7.7%, triple vessel in 2.6% patients. Conclusions: Acute myocardial infarction in young predominantly affects males. Dyslipidemia, smoking and alcoholism were found to be common associated factors in young MI. This emphasizes the need for lifestyle modification for primary prevention. Coronary angiography revealed normal coronaries in 12% suggesting different underlying process other than atherosclerosis. With timely intervention and appropriate management, prognosis is good in young MI patients.

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“…[16][17][18] Many studies have shown LAD to be the vessel most commonly involved followed by RCA and LCX in young patients. 10,17 In comparision with old age ACS patients, our study indicates that the distribution of coronary lesions is not age dependant.…”

Section: Discussionmentioning

confidence: 99%