Angiogenic factors in squamous cell carcinoma of the oral cavity: do they have prognostic relevance?

Schimming, Ronald; Reusch, Petra; Kuschnierz, Jens; Schmelzeisen, Rainer

doi:10.1016/j.jcms.2003.11.004

Cited by 42 publications

(37 citation statements)

References 29 publications

(30 reference statements)

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“…Several retrospective studies in HNSCC have demonstrated that VEGF-A expression is associated with clinicopathological factors and/or poor patient's outcome, suggesting that VEGF-A could serve as a prognostic marker (Eisma et al, 1997;Maeda et al, 1998;Mineta et al, 2000;Smith et al, 2000;Lim et al, 2003;Kimura et al, 2004;Uehara et al, 2004;Kyzas et al, 2005b). However, the status of VEGF-A remains unclear since other HNSCC retrospective studies have shown no correlation between VEGF-A expression and tumour prognosis (Salven et al, 1997;Tae et al, 2000;Do et al, 2004;Schimming et al, 2004). These conflicting results may be due partly to the method of detection of VEGF-A expression (ie immunohistochemistry), used in most of the previous reports, and which is a semiquantitative method.…”

mentioning

confidence: 99%

Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance

Onesto

Chamorey

et al. 2006

Br J Cancer

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Vascular endothelial growth factor-A (VEGF-A) has been demonstrated to play an important role in tumour angiogenesis and to influence prognosis in many cancers. However its prognostic value in head and neck squamous cell carcinomas (HNSCCs) remains controversial. Therefore, we investigated the clinical relevance of VEGF-A expression in HNSCCs and analysed whether its expression was associated with PAIP2 protein levels, a VEGF-A mRNA-binding partner that strongly regulates VEGF-A expression in tissue culture. We determined the correlation of VEGF-A and PAIP2 protein levels, quantitatively evaluated in tumour tissue homogenates from 54 patients with HNSCC, to clinicopathological parameters. We showed that VEGF-A expression in HNSCC is correlated to the stage of tumour differentiation ( P =0.050) and is an independent prognostic factor for progression-free survival ( P =0.001) and overall survival ( P =0.0004). In a pharynx carcinoma cell line, we demonstrated by RNA interference that VEGF-A expression is closely controlled by PAIP2. Moreover, in human HNSCCs, VEGF-A expression is significantly correlated to PAIP2 protein levels ( P =0.0018). Nevertheless, PAIP2 expression is associated with neither clinicopathological factors nor patient's survival. Our data suggest that, in contrast to PAIP2 protein levels, which are unrelated to tumour prognosis, VEGF-A expression could serve as a prognostic marker in head and neck cancer and may be helpful for targeted therapies.

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mentioning

confidence: 99%

Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance

Onesto

Chamorey

et al. 2006

Br J Cancer

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“…13 A high vascular density is reportedly associated with advanced tumour stage and a poor prognosis in oral cancers. [11][12][13] We therefore postulated that quantitative evaluation of the vascularity of tongue cancers on Doppler intraoral ultrasonography images predict the grade of malignancy and occurrence of cervical lymph node metastasis and accordingly devise three quantitative indexes of vascularity, the BAR, BNR and BWR. The BAR, which is a measure of the quantity of blood flow within a cancer, did not differ significantly between patients with and without cervical lymph node metastases.…”

Section: Discussionmentioning

confidence: 99%

“…10 High blood vessel density and histological grade of malignancy are significantly related to cervical lymph node metastasis in patients with oral squamouscell carcinoma. [11][12][13] Shinozaki et al 5 reported that the presence of blood vessel infiltration is a determinant of prognosis of cervical lymph node metastasis and that Doppler-identified blood vessel infiltration and lymph duct infiltration have significantly different associations with prognosis. However, no studies have used Doppler intraoral ultrasonography images to quantitatively evaluate vascularity within tumours and in their invasion fronts.…”

Section: Introductionmentioning

confidence: 99%

Vascularity as assessed by Doppler intraoral ultrasound around the invasion front of tongue cancer is a predictor of pathological grade of malignancy and cervical lymph node metastasis

Yamamoto¹,

Yuasa²,

Okamura³

et al. 2016

Dentomaxillofacial Radiology

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Objectives: To quantitatively evaluate the relationship of vascularity of tongue cancer as demonstrated on intraoral ultrasonography images and tumour thickness with pathological grade of malignancy and the presence of cervical lymph node metastases. Methods: 18 patients with tongue cancer were enrolled in this retrospective study. Using Doppler ultrasonography images of the invasion front of the cancers along the length of their tumour boundaries, three vascular indexes were analysed quantitatively, namely ratio of blood flow signal area within the cancer to whole tumour area (BAR), blood flow signal number ratio (BNR) and blood flow signal width ratio (BWR). The associations between these three indexes and occurrence of cervical lymph node metastasis and pathological grade of malignancy [Yamamoto-Kohama (YK) classification] were assessed. Furthermore, the relationship between tumour thickness and occurrence of cervical lymph node metastasis was evaluated on B-mode intraoral ultrasonography images. Results: There was no significant association between BAR and tumour thickness or occurrence of cervical lymph node metastasis. The BNRs and BWRs of patients with cervical lymph node metastasis were significantly higher than those of patients without nodal involvement. The BWRs of patients with high-grade malignancy (YK-4C) were significantly higher than those of patients with low-grade malignancy (YK-2 or 3). Conclusions: BNR and BWR on the invasion front of the tongue cancer are predictors of pathological grade of malignancy and cervical lymph node metastasis. Dentomaxillofacial Radiology (2016Radiology ( ) 45, 20150372. doi: 10.1259 Cite this article as: Yamamoto C, Yuasa K, Okamura K, Shiraishi T, Miwa K. Vascularity as assessed by Doppler intraoral ultrasound around the invasion front of tongue cancer is a predictor of pathological grade of malignancy and cervical lymph node metastasis. Dentomaxillofac Radiol 2016; 45: 20150372.

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“…A expressão protéica de CD105 no tecido tumoral é correlacionada com invasão microvascular, mas parece haver uma correlação inversa entre a densidade vascular e a progressão do tumor. Nas últimas décadas, numerosos estudos têm sido desenvolvidos para correlacionar os fatores angiogênicos e densidade microvascular (DMV) do tumor, com suas características clínicas e patológicas Albo et al, 1994;Schimming et al, 2004). A DMV foi determinada com anticorpo anti-CD105 e estabelecida como um fator independente de prognóstico, com níveis mais elevados relacionando-se diretamente com menor sobrevida câncer-específica.…”

Section: Discussionunclassified

“…Nas últimas décadas, inúmeros estudos foram desenvolvidos a fim de correlacionar os fatores angiogênicos e a densidade vascular do tumor com os aspectos clínicopatológicos da doença Albo et al, 1994;Schimming et al, 2004 (Carmeliet, 2005). Está localizado no gene 6p21.3 em humanos (Ferrara; DavisSmyth, 1997), sendo importante regulador da vasculogênese e angiogênese .…”

Section: Em Estudo Avaliando a Expressão Gênica Da Molécula De Adesãounclassified

Análise da expressão dos genes CD105 (endoglina), VEGF, VEGFR1 e VEGFR2 no carcinoma de células renais e correlação com fatores prognósticos

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Angiogenic factors in squamous cell carcinoma of the oral cavity: do they have prognostic relevance?

Cited by 42 publications

References 29 publications

Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance

Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance

Vascularity as assessed by Doppler intraoral ultrasound around the invasion front of tongue cancer is a predictor of pathological grade of malignancy and cervical lymph node metastasis

Análise da expressão dos genes CD105 (endoglina), VEGF, VEGFR1 e VEGFR2 no carcinoma de células renais e correlação com fatores prognósticos

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