2005
DOI: 10.1007/s00408-004-2533-0
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Abstract: The angiogenesis system has been implicated in inflammatory and neoplastic processes; nevertheless, it has been little studied in relation to the pleural space. Our aim is to analyze pleural and plasma levels of the activators--vascular endothelial growth factor, basic fibroblastic growth factor, and inhibitors--endostatin and thrombospondin-1 and to estimate the association between these factors and related biochemical markers. We analyzed pleural fluid from 105 patients with one of the following types of ple… Show more

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Cited by 24 publications
(31 citation statements)
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“…RUIZ et al [36] reported that angiogenic activators were higher in neoplastic pleural effusions than nonmalignant effusions. However, no significant difference in endostatin levels was noticed.…”
Section: Discussionmentioning
confidence: 99%
“…RUIZ et al [36] reported that angiogenic activators were higher in neoplastic pleural effusions than nonmalignant effusions. However, no significant difference in endostatin levels was noticed.…”
Section: Discussionmentioning
confidence: 99%
“…Following independent review, 181 publications concerning VEGF and pleural effusions were considered to be eligible for inclusion in the analysis. Of these publications, 144 were excluded for being beyond the scope of the present study, one was excluded due to the lack of a control group (9), two letters to the editor were excluded due to the limited data they contained (21,22), four publications were excluded as they recruited <10 patients in one of study groups (10,11,14,23) and 20 were excluded as they did not allow data extraction or calculation of the sensitivity and specificity (12,13,(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41). The remaining 10 studies, based on 514 patients with MPE and 511 without MPE, were available for the meta-analysis (42-51).…”
Section: Resultsmentioning
confidence: 99%
“…Both angiogenic factors and angiogenesis inhibitors are likely contributors to the formation of effusion in the pleural space (Ruiz et al, 2005). Endostatin is one of a number of endogenously generated antiangiogenic protein fragments that have been shown to have antitumor activity in murine models (Skovseth et al, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…Endostatin is one of a number of endogenously generated antiangiogenic protein fragments that have been shown to have antitumor activity in murine models (Skovseth et al, 2005). Although serum levels of endostatin have extensively been studied in patients with malignant diseases, only a few studies evaluated endostatin levels in PE (Sumi et al, 2003;Ruiz et al, 2005;Sack et al, 2005;Zhang et al, 2012;Koniari et al, 2011;Hsu et al, 2009;Yanagawa et al, 1999;Ziora et al, 2002;Fiorelli et al, 2011;. Previous studies reported that in comparison with either VEGF or endostatin determination in serum or pleural fluid, the combined detection of two factors improved the diagnostic sensitivity and accuracy (Zhang et al, 2012;Zhou et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
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