2021
DOI: 10.1021/acsami.1c08565
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Abstract: In a search for a solution to large-area soft and hard tissue defects, whether or not tissue regeneration or tissue-substitutes transplantation is used, the problems with angiogenesis need to be solved urgently. Thus, a new and efficient proangiogenic approach is needed. Nanoengineering systems have been considered one of the most promising approaches. In this study, we modify the tetrahedral framework nucleic acid (tFNA) for the first time with two different angiogenic DNA aptamers to form aptamer–tFNA nanost… Show more

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Cited by 20 publications
(24 citation statements)
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“…The osteogenic function of cells that promote bone regeneration requires a network of microvessels, which mediate the transport of circulating of cells, oxygen, nutrients, and waste products ( Laschke and Menger, 2015 ). Besides, Zhao et al modified the tetrahedral framework nucleic acid (tFNA) with aptamers to form aptamer-tFNA nanostructures, tFNA-Apt02 and tFNA-AptVEGF, and they exhibited stronger angiogenesis, further provided a new and efficient proangiogenic approach ( Zhao et al, 2021 ). Therefore, newly formed microvessels within grafts are critical for successful bone tissue engineering.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The osteogenic function of cells that promote bone regeneration requires a network of microvessels, which mediate the transport of circulating of cells, oxygen, nutrients, and waste products ( Laschke and Menger, 2015 ). Besides, Zhao et al modified the tetrahedral framework nucleic acid (tFNA) with aptamers to form aptamer-tFNA nanostructures, tFNA-Apt02 and tFNA-AptVEGF, and they exhibited stronger angiogenesis, further provided a new and efficient proangiogenic approach ( Zhao et al, 2021 ). Therefore, newly formed microvessels within grafts are critical for successful bone tissue engineering.…”
Section: Discussionmentioning
confidence: 99%
“…The role of SPRY2 in angiogenesis and the regulation of SPRY2 by the miR-23/27 cluster has been previously demonstrated (Zhou et al, 2011), as well as the regulation of SPRY2 by miR-21 (Thum et al, 2008). Li et al fabricated the resultant bioswitchable nanocomposite by integrating the sticky-end tFNA (stFNA) and miRs (miR-21, miR-124, miR-335, and miR-2861), further promoting bone regeneration via inhibiting the expression of HDAC5 (Li S. et al, 2021). A similar research reported that exosomal miR-21 derived from umbilical MSC-sEVs promoted angiogenesis by upregulating the NOTCH1/DLL4 pathway (Zhang et al, 2021).…”
Section: Discussionmentioning
confidence: 99%
“…Fluorescence images of each sample were obtained under a confocal laser microscope (Nikon, Tokyo, Japan). 29 , 30 …”
Section: Methodsmentioning
confidence: 99%
“… 144 Apt02 AptVEGF aptamer tFNA in vitro human umbilical vein endothelial cells in vivo female BALB/c mice promoted endothelial cell proliferation and migration increased tubule formation enhanced spheroid sprouting promoted formation of microvessels Zhao et al. 145 Alg@ori, oridonin alginate microspheres; ALG/PVA, alginate/poly-(vinyl alcohol); Amo, anti-miRNA oligonucleotides; anti-VEGF-R2, anti-vascular endothelial growth factor receptor-2; CHT/PVA, chitosan/poly-(vinyl alcohol); FKBPL, FK506-binding protein-like; HA-ADH, adipic dihydrazide-modified hyaluronic acid; HA-PEI, hyaluronic acid-polyethyleneimine; IL-6, interleukin 6; LbL, layer-by-layer; LPP, lipoproteoplex; miRNA, microRNA; OHMPC, oxidized hydroxymethyl propyl cellulose; PDGFα, platelet-derived growth factor subunit α; PEI, polyethyleneimine; PEUR, poly(ester urethane); PHD2, prolyl hydroxylase domain protein 2 PTK-UR, poly(thioketal urethane); SD, Sprague-Dawley; shRNA, short hairpin RNA; siRNA, short interfering RNA; STZ, streptozotocin; tFNA, tetrahedral framework nucleic acid; tHA-PEGDA, thiolated hyaluronic acid-polyethylene diacrylate; TNF-α, tumor necrosis factor α; α -SMA, alpha smooth muscle actin. …”
Section: Gene-silencing-based Therapeutics For Wound Angiogenesismentioning
confidence: 99%
“…By this combination, they showed tFNA-Apt02 and tFNA-AptVEGF had a stronger ability to promote endothelial cell proliferation and migration, tubule formation, spheroid sprouting, and formation of microvessels in vivo ( Figure 11 C). 145 …”
Section: Gene-silencing-based Therapeutics For Wound Angiogenesismentioning
confidence: 99%