Angiogenesis and host immune response contribute to the aggressive character of non-melanoma skin cancers in renal transplant recipients

Mackenzie, K. A.; Miller, Andrew P.; Hock, Barry D.; Gardner, Jacqui; Simcock, Jeremy; Roake, Justin; Dachs, Gabi U.; Robinson, Bridget A.; Currie, Margaret J.

doi:10.1111/j.1365-2559.2011.03845.x

Cited by 15 publications

(9 citation statements)

References 38 publications

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“…In a cohort of 598 kidney transplant recipients, low plasma ascorbate status was associated with risk of death from cancer [ 36 ]. Kidney transplant recipients are known to be at increased risk of several cancer types due to ongoing immune-suppression [ 37 ], and there is growing evidence of the importance of ascorbate in immune cell function [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics

et al. 2020

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Vitamin C (ascorbate) acts as an antioxidant and enzyme cofactor, and plays a vital role in human health. Vitamin C status can be affected by illness, with low levels being associated with disease due to accelerated turnover. However, robust data on the ascorbate status of patients with cancer are sparse. This study aimed to accurately measure ascorbate concentrations in plasma from patients with cancer, and determine associations with patient or tumor characteristics. We recruited 150 fasting patients with cancer (of 199 total recruited) from two cohorts, either prior to cancer surgery or during cancer chemo- or immunotherapy. A significant number of patients with cancer had inadequate plasma ascorbate concentrations. Low plasma status was more prevalent in patients undergoing cancer therapy. Ascorbate status was higher in women than in men, and exercising patients had higher levels than sedentary patients. Our study may prompt increased vigilance of ascorbate status in cancer patients.

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Section: Discussionmentioning

confidence: 99%

Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics

et al. 2020

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“…Tumors in NMSC have been shown to be more aggressive in recipients of solid organ transplants; one of the factors responsible for this aggressiveness may be the presence of angiogenic factors in the tumor that stimulate its growth . Other rare skin tumors also occur at an increased incidence in the solid organ transplant population, such as Merkel cell tumor, angiosarcoma, cutaneous lymphoma, Kaposi's sarcoma, and sebaceous carcinoma .…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and clinical evolution of non‐melanoma skin cancer in renal transplant recipients: a single‐center experience in São Paulo, Brazil

Hayashida

Fernandes

et al. 2015

Int J Dermatology

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“…Vascular endothelial growth factor (VeGF) and platelet-derived growth factor (PDGF) are the most potent identified tumour pro-angiogenic factor (Mackenzie et al 2011). Using 30% of the IC 50 of the tested sample to treat of Mcf-7 cells resulted in a significant inhibition in the VeGF concentration (p < 0.05) and a non-significant reduction in PDGF concentration compared to the significant inhibition to both of VeGF and PDGF by thalidomide, a known antiangiogenic drug (p < 0.01), as shown in Supplementary Figure S10.…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory, antioxidant and antiangiogenic activities of diosgenin isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm

Selim

Jaouni²

2015

Natural Product Research

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Costus speciosus is an important medicinal plant widely used in several indigenous medicinal formulations. The present study was conducted to evaluate the in vitro anti-inflammatory, antioxidant and antiangiogenic activities of diosgenin isolated from C. speciosus. The diosgenin was isolated from C. speciosus by HPTLC and its biological activities were studied by different protocols. The results demonstrated that LPS stimulated TNF-α generation in RAW 264.7 macrophage culture supernatant up to 3.7-fold of the control and that sample treatment (50 μg/mL) resulted in a highly significant inhibitory effect on LPS-stimulated TNF-α (p < 0.01) in a similar manner to methotrexate inhibitory effect. The tested sample possessed an effective antioxidant scavenging affinity against DPPH radicals as compared with the standard antioxidant activity of vitamin C. The results presented here may suggest that diosgenin isolated from C. speciosus possess anticancer, apoptotic and inhibitory effects on cell proliferation.

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Angiogenesis and host immune response contribute to the aggressive character of non-melanoma skin cancers in renal transplant recipients

Abstract: This study demonstrates increased tumour angiogenesis in NMSC in RTRs, and suggests a role for VEGF-A-positive peritumoural leukocytes in suppressing NMSC development.

Cited by 15 publications

References 38 publications

Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics

Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics

Epidemiology and clinical evolution of non‐melanoma skin cancer in renal transplant recipients: a single‐center experience in São Paulo, Brazil

Anti-inflammatory, antioxidant and antiangiogenic activities of diosgenin isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm

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