Anemia of Old Age

Sanford, Angela M.; Morley, John E.

doi:10.1007/s12603-019-1214-x

Cited by 9 publications

(9 citation statements)

References 32 publications

(24 reference statements)

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“…Similarly to dolphins, as humans age, they exhibit declining hemoglobin levels and a higher prevalence of anemia (also defined as hemoglobin <12 g/dL) ( 44 ). Anemia with aging has been attributed to greater RBC fragility and is a risk factor for increased morbidity and mortality ( 45 – 48 ). The estimated prevalence of older individuals with anemia globally ranges from 20% to 76% ( 48 , 49 ).…”

Section: Discussionmentioning

confidence: 99%

“…The estimated prevalence of older individuals with anemia globally ranges from 20% to 76% ( 48 , 49 ). While one-third of cases of anemia among the elderly are attributed to nutritional deficiencies and another third are characterized as anemia of chronic disease, one-third of cases are classified as “unexplained” anemia or “anemia of old age” ( 47 , 49 ). Along with our present findings, these data support the notion that anemia of old age may be associated with, or the product of, an accelerated aging rate in a subset of individuals.…”

Section: Discussionmentioning

confidence: 99%

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A 25-y longitudinal dolphin cohort supports that long-lived individuals in same environment exhibit variation in aging rates

Venn‐Watson

Jensen

Schork

2020

Proc. Natl. Acad. Sci. U.S.A.

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While it is believed that humans age at different rates, a lack of robust longitudinal human studies using consensus biomarkers meant to capture aging rates has hindered an understanding of the degree to which individuals vary in their rates of aging. Because bottlenose dolphins are long-lived mammals that develop comorbidities of aging similar to humans, we analyzed data from a well-controlled, 25-y longitudinal cohort of 144 US Navy dolphins housed in the same oceanic environment. Our analysis focused on 44 clinically relevant hematologic and clinical chemistry measures recorded during routine blood draws throughout the dolphins’ lifetimes. Using stepwise regression and general linear models that accommodate correlations between measures obtained on individual dolphins, we demonstrate that, in a manner similar to humans, dolphins exhibit independent and linear age-related declines in four of these measures: hemoglobin, alkaline phosphatase, platelets, and lymphocytes. Using linear regressions and analyses of covariance with post hoc Tukey–Kramer tests to compare slopes (i.e., linear age-related rates) of our four aging rate biomarkers among 34 individual dolphins aging from 10 y to up to 40 y old, we could identify slow and accelerated agers and differentiate subgroups that were more or less likely to develop anemia and lymphopenia. This study successfully documents aging rate differences over the lifetime of long-lived individuals in a controlled environment. Our study suggests that nonenvironmental factors influencing aging rate biomarkers, including declining hemoglobin and anemia, may be targeted to delay the effects of aging in a compelling model of human biology.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A 25-y longitudinal dolphin cohort supports that long-lived individuals in same environment exhibit variation in aging rates

Venn‐Watson

Jensen

Schork

2020

Proc. Natl. Acad. Sci. U.S.A.

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“…The increasing importance of this concept of in-depth primary care-based analysis of various etiological factors contributing to anemia in the elderly has also been brought to light in multiple other recent reports from international literature. [21222324] Keeping in mind the comparatively small sample size included in the study, the authors acknowledge that a larger population-based study will better reflect on the prevalence and causes of anemias in asymptomatic elderly subjects and is hence recommended.…”

Section: Discussionmentioning

confidence: 99%

Does aging have an impact on hemoglobin? Study in elderly population at rural teaching hospital

Raisinghani

Kumar

Acharya

et al. 2019

J Family Med Prim Care

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Background:The prevalence of anemia increases with age. Some serious underlying conditions may lead to anemia in the old age. The present study was undertaken to detect and do morphological typing of anemia and further delineate etiological factors in elderly patients.Methods:In this hospital-based prevalence study carried out a tertiary care center over one and half years, a total of 90 patients were fully evaluated for etiology and typing of anemia in elderly (>60 years age) patients. Details of other significant medical and surgical history were noted. Laboratory investigations were conducted, which included complete hemogram, peripheral blood smear, reticulocyte count, erythrocyte sedimentation rate estimation, serum urea, serum creatinine and serum lactate dehydrogenase, bone marrow examination (with Prussian blue marrow iron staining), serum iron and serum total iron-binding capacity, serum ferritin, and stool and urine examination.Results:The mean hemoglobin as per age was 60–64 years- 5.95 gm%, 65–69 years - 6.7 gm%, 70–74 years - 6.58 gm%, and 75–79 years - 6.87 gm%. The difference not being significant (p = 0.33). Morphologically, 53 patients (24 males and 29 females) had microcytic anemia, 27 (17 males and 10 females) had normocytic anemia, and 10 (8 males and 2 females) had macrocytic anemia. Anemia of chronic disease (ACD) was the most common occurrence (50, 55.56%), followed by iron deficiency anemia (IDA) (27, 30%), macrocytic anemia (9, 10%), and others 4 (4.44%). The cause of anemia was found in 10 out of 27 (37.03%) patients in the IDA group, 28 out of 50 (56%) in the ACD group, whereas the etiology was discernible in only one out of nine cases (11.1%) of macrocytic anemias.Conclusion:There was no significant difference observed in the mean hemoglobin levels as the age increased. Morphologically, the majority of the patients had microcytic anemia, followed by normocytic anemia. A population-based study is recommended for further assessment of the prevalence and causes of anemias in asymptomatic elderly subjects.

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“…It has been noticed that there are 75% chances of negligence of symptoms by the patients [29,30]. Also no related positive finding could be recognized on general physical examinations as there are insufficient signs on physical examination that are specific for mild to moderate anemia [3,31,32]. However signs and symptoms vary from weakness, irritability, alopecia, xerostomia and depression especially in iron deficiency anemia (IDA).…”

Section: Clinical Featuresmentioning

confidence: 99%

“…At the same time as considering the sociodemographic profile as a causative factor, geriatric anemia was significantly seen associated with high socioeconomic status followed by employment and chronic diseases [45,46]. Another aspect discussed by Freedman ML and associate suggested that low values in elderly especially in men is a physiologic phenomenon or values of anemia need to be revised in this age group is not known [31,47].…”

Section: Etiopathogenesismentioning

confidence: 99%

Geriatric Anemia

Rana¹,

Rana²

2021

Update in Geriatrics

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Anemia is growing in importance as a public health issue and a biomedical research priority in the geriatric age group but data on the causes and prevalence is not substantial. World health organization (WHO) has defined anemia as hemoglobin concentration (Hb %) below 12 g/dL in women and below 13 g/dL in men. Although it was previously believed that decline in Hb levels might be a normal consequence of aging, later suggested that anemia does reflect underlying poor health and makes elders vulnerable to adverse outcomes. Geriatric anemia has been found to be prevalent in up to 21.1% of patients in Europe and 11.0% of men and 10.2% of women of 65 years and older in the US. There is little literature that explores the various causes of anemia and its association with socio-demographic profile with underlying diseases, hence lesser research has led anemia to go undiagnosed and untreated.

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Anemia of Old Age

Cited by 9 publications

References 32 publications

A 25-y longitudinal dolphin cohort supports that long-lived individuals in same environment exhibit variation in aging rates

A 25-y longitudinal dolphin cohort supports that long-lived individuals in same environment exhibit variation in aging rates

Does aging have an impact on hemoglobin? Study in elderly population at rural teaching hospital

Geriatric Anemia

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