Anemia in Infancy

Kett, Jennifer

doi:10.1542/pir.33-4-186

Cited by 21 publications

(31 citation statements)

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“…Red blood cell count decreases until oxygen delivery is inadequate for metabolic demand and erythropoietin production is stimulated again. In healthy term infants, the red blood cell nadir, a physiologic response to postnatal life and not a hematologic disorder, typically occurs at 8 to 12 weeks of life and at a haemoglobin level of 9-11 g/dl [20].…”

Section: Associated Between Anemia In Breastfeeding Mothers With Amentioning

confidence: 99%

Stunting and Anemia in Infants Among Breastfeeding Mothers in Binjai City

Sudaryati

Nasution

Yustina

2017

Proceedings of the 1st Public Health International Conference (PHICo 2016)

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Abstract-Anemia and stunting are major public health problems, and they have a high prevalence rate in Southeast Asia. In this cross-sectional study, infants from 0 to 6 months and their mothers were investigated to determine the prevalence of stunting and anemia in infants and anemia in breastfeeding mothers. Multistage cluster was used as sampling techniquein selecting five sub districtsin Binjai City of North Sumatera Province, Indonesia. Analysis uses the information of hemoglobin levels from 100 breastfeeding infants and their mothers which have their peripheral blood tested by hemocue. Examination of anemia infants based on the levels of hemoglobin give results <14g/dL for 0-3 days of age, <13g/dL for one weekof age, <12g/dLfor 2 weeks of age, <11g/dL for 1 month of age, <10g/dL for 2-6 monthsof age. Anthropometric indicator (range-for-age ≤2SD) were measured for stunting infants. Data analysis uses chi-square test. The overall prevalence of anemia in infants was 29%, and anemia in breastfeeding mothers was 52%, while prevalence of stunting in infants was 34%. Anemia in breastfeeding mothers is not associated with infant anemia (p=0.685 > 0.05), and with stunting in infant (p=0.161 > 0.05). Hb concentration in infants were not statistically different (p=0.83) among breastfeeding mothers which are anemia (11.4±1.7 g/dL) and non anemia (11.5±2.2 g/dL). The results of this study indicate that maternal anemia during breastfeeding was not associated with anemia and stunting in infants. These results are very important as a baseline for prevention planning of stunting and anemia in children.

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Section: Associated Between Anemia In Breastfeeding Mothers With Amentioning

confidence: 99%

Stunting and Anemia in Infants Among Breastfeeding Mothers in Binjai City

Sudaryati

Nasution

Yustina

2017

Proceedings of the 1st Public Health International Conference (PHICo 2016)

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“…Anemia is defined as hematocrit or hemoglobin concentration <2 SD below age specific mean [1]. The etiology can be broadly classified into a) decreased production of RBC's, b) increased destruction of RBC's or c) increased blood loss in the fetus [2].…”

Section: Discussionmentioning

confidence: 99%

Silent Feto-Maternal Bleed as a Cause of Severe Neonatal Anemia

2016

J Paediatr Child Care

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Feto-maternal bleed is a common presentation during pregnancy that may have adverse consequences on the perinatal clinical course of the infant and mother alike. Anemia is a common presentation of an infant secondary to feto-maternal bleed. Large volume feto-maternal bleeds may lead to severe neonatal anemia in the absence of obvious maternal symptoms. Hence, a high index of suspicion must be maintained in the absence of other obvious causes of neonatal anemia. We describe a case of an infant with severe anemia secondary to a silent feto-maternal bleed associated with a normal appearing placenta on examination and the absence of obvious maternal symptoms.sepsis. Transcutaneous bilirubin was measured at 0.8 mg/dl and later a serum bilirubin showed an unconjugated bilirubin of 0.5 mg/dl and conjugated bilirubin of 0.0 mg/dl. On physical exam, baby had a normal anterior fontanelle without any signs of bulging and a soft non-distended, non-tender abdomen with normal bowel sounds. 20 ml/kg of packed red blood cells was emergently transfused. Blood was transfused over 4 hours in 2 aliquots without any complications. CBC post transfusion showed a Hgb of 10.9 g/dl and a Hct of 31.6%, The heart murmur was no longer audible post transfusion. The baby continued to be hemodynamically stable post transfusion. Hemoglobin electrophoresis was sent and it returned normal results. Further maternal history and an additional bedside test revealed the diagnosis.

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“…The former is important in understanding the mechanisms involved in red blood cell (RBC) production in the hypoxic intrauterine environment, while the latter provides a better understanding of the newborn infant's ability to compensate for the expected decline in postnatal erythropoietic activity that predictably results from the increased oxygen availability and resulting downregulation of erythropoietin synthesis and release (1)(2)(3). In anemic preterm infants, the latter also provides information about the critically ill infant's ability to compensate for blood loss due to the multiple clinical phlebotomies that commonly results from required neonatal care.…”

Section: Introductionmentioning

confidence: 99%

A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs

Kuruvilla

Widness

Nalbant

et al. 2015

AAPS J

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Abstract. Fetal RBCs are produced during a period of very rapid growth and stimulated erythropoiesis under hypoxic intrauterine conditions. Fetal RBC life span varies with gestational age (GA) and is shorter than that in healthy adults. Due to the special kinetic properties of life span-based survival of human RBCs, a mathematical model-based kinetic analysis of the survival of fetal RBCs shortly after birth provides a unique opportunity to Blook backward in time^to evaluate fetal erythropoiesis. This work introduces a novel method that utilizes postnatal in vivo RBC survival data collected within 2 days after birth to study both nonsteady-state (non-SS) in utero RBC production and changing fetal RBC life span over time. The effect of changes in erythropoiesis rate and RBC life span and the effect of multiple postnatal phlebotomies on the RBC survival curves were investigated using model-based simulations. This mathematical model, which considers both changes in the rate of erythropoiesis and RBC life span and which accurately accounts for the confounding effect of multiple phlebotomies, was applied to survival curves for biotin-labeled RBCs from ten anemic very low birth weight preterm infants. The estimated mean fetal RBC production rate scaled by body weight was 1.07×107 RBCs/day g, and the mean RBC life span at birth was 52.1 days; these values are consistent with reported values. The in utero RBC life span increased at a rate of 0.51 days per day of gestation. We conclude that the proposed mathematical model and its implementation provide a flexible framework to study in utero non-SS fetal erythropoiesis in newborn infants.

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Anemia in Infancy

Cited by 21 publications

References 0 publications

Stunting and Anemia in Infants Among Breastfeeding Mothers in Binjai City

Stunting and Anemia in Infants Among Breastfeeding Mothers in Binjai City

Silent Feto-Maternal Bleed as a Cause of Severe Neonatal Anemia

A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs

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