Anemia in Children with and without Helicobacter pylori Infection

Haghi-Ashtiani, Mohammad Taghi; Monajemzadeh, Maryam; Motamed, Farzaneh; Mahjoub, Fatemeh; Sharifan, Mojgan; Shahsiah, Reza; Kashef, Nasim

doi:10.1016/j.arcmed.2008.04.005

Cited by 19 publications

(19 citation statements)

References 30 publications

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“…Different results have been achieved in Iran, where the frequency of H. pylori infection in children with and without anemia was similar (44 vs 50%). Among infected children, 36% had anemia vs 42.2% ( p = .59) in noninfected ones [61]. Similar findings have been reported in Northwest Turkey where authors hypothesized that IDA might be explained by inadequate dietary intake [62].…”

Section: Hematologic Diseasessupporting

confidence: 64%

Helicobacters and Extragastric Diseases

et al. 2009

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For two decades, Helicobacter pylori has been considered as the culprit in many extragastric manifestations. However, for several of these supposed associations the hypothesis of an etiological role has not yet been fully investigated. This may be due to a series of factors linked to the epidemiological features of the studies and to the diseases investigated. This review attempts to highlight the main reported associations of H. pylori with extragastric manifestations during the last year. The most convincing data arise in the field of idiopathic thrombocytopenic purpura (ITP) and sideropenic anemia. Long-term follow-up studies have shown that 50% of subjects with ITP maintain a hematological response after H. pylori eradication. There is also growing evidence of the role of H. pylori in other diseases, including ischemic heart disease even though results are not conclusive.

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Section: Hematologic Diseasessupporting

confidence: 64%

Helicobacters and Extragastric Diseases

et al. 2009

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“…Case reports, observational epidemiologic studies and small intervention trials [10–12,22,23], provided evidence on the association between H. pylori infection and decreased iron stores. In contrast, such association could not be established in other observational studies conducted among children [13–16]. It has been suggested that age might have effect modification on the association between H. pylori infection and iron deficiency in Alaskan children [11].…”

Section: Discussionmentioning

confidence: 94%

“…An association between H. pylori infection and reduced iron stores has been reported in various countries [8–12]; however, this association in children is poorly understood. Some studies conducted among school‐age children and adolescents [8,10–12] found an association between H. pylori infection and increased prevalence of iron deficiency or iron deficiency anemia, others reported negative results [13–16]. A study carried out among 7‐ to 11‐ year‐old Native Alaskan children showed effect modification of age; the association between H. pylori infection and iron deficiency was evident only in children aged 9 years or more [11].…”

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confidence: 99%

Is the Association Between Helicobacter pylori Infection and Anemia Age Dependent?

et al. 2010

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“…They found a lower prevalence of iron deficiency and IDA in H. pylori ‐negative children compared with H. pylori ‐positive children [21]. On the other hand, no association between H. pylori infection and IDA was seen in three other studies [22–24]. It is indeed difficult to distinguish between anemia due to infection with H. pylori and to other confounding factors, such as poor nutritional status or another underlying disease.…”

Section: Extra‐gastrointestinal Manifestationsmentioning

confidence: 99%

Helicobacter pylori Infection in Pediatrics

Kindermann

Lopes

2009

Helicobacter

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his review summarizes the articles published on Helicobacter pylori infection in children between April 2008 and March 2009. Recent evidence highlights the decreasing prevalence trend of H. pylori infection and supports both intrafamilial and extrafamilial transmission. The association with various symptoms is still being debated. Interestingly, H. pylori infection seems inversely associated with allergic diseases. Monoclonal stool antigen tests are widely used and accurate for the diagnosis of H. pylori infection, but less accurate in young children. The new biprobe real-time PCR assay applied to stools showed a poor sensitivity in children. Using the urea hydrolysis rate next to the delta over baseline values, the (13)C-urea breath test provides excellent results for all age children, even for young children. Treatment of H. pylori infection remains a challenge, considering suboptimal efficacy of current therapy. Among emerging alternatives, sequential treatment appears promising. The adjunction of probiotics to conventional regimens, although eliciting great interest, has shown limited therapeutic benefit.

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Anemia in Children with and without Helicobacter pylori Infection

Cited by 19 publications

References 30 publications

Helicobacters and Extragastric Diseases

Helicobacters and Extragastric Diseases

Is the Association Between Helicobacter pylori Infection and Anemia Age Dependent?

Helicobacter pylori Infection in Pediatrics

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