Anemia and Low Albumin Levels Are Associated with Severe Community-Acquired Pneumonia in Pregnancy: A Case-Control Study

He, Yanjun; Li, Miaogen; Mai, Caiyuan; Chen, Lujing; Zhang, Xiaoman; Zhou, Jing; Yang, Zhen; Ni, Jia Yan; Chen, Yongxing; Cai, Ming; Qi, Qinglian; Yang, Zaibin

doi:10.1620/tjem.248.297

Cited by 10 publications

(5 citation statements)

References 36 publications

(54 reference statements)

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“…In some studies of pregnancy with community-acquired pneumonia, anemia, hypoproteinemia, and low BMI were proved as risk factors for severe community-acquired pneumonia. 23 Among the patients with COVID-19, we also found that level of hemoglobin and albumin was significantly lower in severe cases than that of mild cases, 24…”

Section: Con S Ider Ati On S On the Delivery Manag Ement For S E Vementioning

confidence: 78%

Pregnancy with COVID‐19: Management considerations for care of severe and critically ill cases

Chen

Jiang

Zhao

2020

American J Rep Immunol

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has been spreading globally, causing over 340 000 deaths. 1 Based on the previous knowledge of two notable coronavirus outbreaks, the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), it is suggested that pregnant women are particularly susceptible to adverse outcomes, including the need for endotracheal intubation, admission to an intensive care unit (ICU), acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndrome (MODS), and even death. 2-4 Also, there is combined with a high incidence of adverse fetal outcomes, including stillbirth, fetal growth restriction, and preterm birth. However, current research suggests that maternal severity with COVID-19 is similar to that of non-pregnant women, with a rate of severe pneumonia at 0%-18%. 5,6 A few critically ill cases have also been reported, causing maternal death and fetal loss. This may indicate that the effect of novel coronavirus (COVID-19) infection on pregnant women may be different from that of SARS and MERS. It is well known that most pregnancy complications, such as hypertensive disorders of pregnancy, will be relieved after the termination of pregnancy. But for COVID-19, we found that postpartum exacerbation presented due to short-term pathophysiological changes immediately after delivery. 7 Gestational weeks of infection, the maturity of the fetus, disease severity, and postpartum exacerbation make the management of severe and critically ill cases of pregnant women with COVID-19 more difficult. This article is mainly to explore those issues and make some clinical suggestions.

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Section: Con S Ider Ati On S On the Delivery Manag Ement For S E Vementioning

confidence: 78%

Pregnancy with COVID‐19: Management considerations for care of severe and critically ill cases

Chen

Jiang

Zhao

2020

American J Rep Immunol

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“…The results found that there were positive correlations between serum resistin and inflammatory cytokines among CAP patients. Furthermore, an earlier project from our research group found that blood routine indices, liver function, and renal function can serve as indicators for pneumonia (27)(28)(29).…”

Section: Discussionmentioning

confidence: 89%

Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia

Chen

Cheng

et al. 2021

Front. Immunol.

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BackgroundResistin is an endogenous ligand of Toll-like receptor 4 that activates several inflammatory signals. But the physiological function of resistin in community-acquired pneumonia (CAP) remains unknown. The goal of this research was to explore the associations between serum resistin and the severity and prognosis in CAP patients through a retrospective cohort study.MethodsAll 212 CAP patients and 106 healthy cases were enrolled. Demographic characteristics were extracted. Serum resistin was determined via enzyme-linked immunosorbent assay. The prognosis was tracked in CAP patients.ResultsSerum resistin on admission was raised in CAP patients compared with control cases. The level of resistin was gradually increased in parallel with CAP severity scores in CAP patients. Pearson and Spearman analyses revealed that serum resistin was positively correlated with CAP severity scores, white blood cells, urea nitrogen, creatinine, and inflammatory cytokines among CAP patients. There were negative relationships between resistin and hematocrit and albumin in CAP patients. Besides, linear and logistic regression analyses further indicated that serum resistin on admission was positively associated with CAP severity scores among CAP patients. Follow-up research revealed that serum resistin elevation on admission prolonged hospital stay in CAP patients.ConclusionSerum resistin on admission is positively correlated with the severity and hospital stay in CAP patients, indicating that resistin may be involved in the physiological process of CAP. Serum resistin may be a potential biomarker in the diagnosis and prognosis for CAP.

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“…Although no study has reported that HB values can predict the occurrence of CIP, He et al. found that low HB was independently associated with the occurrence of community-acquired pneumonia in pregnant women ( 27 ). HB plays the role of transporting oxygen, and its deficiency is related to hypoxia, which may promote the deficiency of lung function, making patients susceptible to pneumonitis.…”

Section: Discussionmentioning

confidence: 99%

“…One study found that a low serum ALB level with pembrolizumab was an independent predictor of CIP (25), consistent with the finding of our study. In addition, Hu et al found that increased ALB concentration was associated with improved lung function (26). ALB is an acute phase reactant that can show the inflammatory state of the body; a decrease in ALB may be related to the inflammatory state of the body, and these mechanisms lead to the occurrence of CIP.…”

Section: Characteristics Numbermentioning

confidence: 99%

Predictive factors and prognosis of immune checkpoint inhibitor-related pneumonitis in non-small cell lung cancer patients

et al. 2023

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ObjectiveTo investigate the influencing factors and prognosis of immune checkpoint inhibitor-related pneumonitis (CIP) in advanced non-small cell lung cancer (NSCLC) patients during or after receiving immune checkpoint inhibitors(ICIs).MethodsThe clinical and laboratory indicator data of 222 advanced NSCLC patients treated with PD-1/PD-L1 inhibitors at the First Affiliated Hospital of Zhengzhou University between December 2017 and November 2021 were collected retrospectively. The patients were divided into a CIP group (n=41) and a non-CIP group (n=181) according to whether they developed CIP or not before the end of follow-up. Logistic regression was used to evaluate risk factors of CIP, and Kaplan‒Meier curves were used to describe the overall survival (OS) of different groups. The log-rank test was used to compare the survival of different groups.ResultsThere were 41 patients who developed CIP, and the incidence rate of CIP was 18.5%. Univariate and multivariate logistic regression analyses showed that low pretreatment hemoglobin (HB) and albumin (ALB) levels were independent risk factors for CIP. Univariate analysis suggested that history of chest radiotherapy was related to the incidence of CIP. The median OS of the CIP group and non-CIP were 15.63 months and 30.50 months (HR:2.167; 95%CI: 1.355-3.463, P<0.05), respectively. Univariate and multivariate COX analyses suggested that a high neutrophil-to-lymphocyte ratio (NLR) level, a low ALB level and the development of CIP were independent prognostic factors for worse OS of advanced NSCLC patients treated with ICIs. Additionally, the early-onset and high-grade CIP were related to shorter OS in the subgroup.ConclusionLower pretreatment HB and ALB levels were independent risk factors for CIP. A high NLR level, a low ALB level and the development of CIP were independent risk factors for the prognosis of advanced NSCLC patients treated with ICIs.

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Anemia and Low Albumin Levels Are Associated with Severe Community-Acquired Pneumonia in Pregnancy: A Case-Control Study

Cited by 10 publications

References 36 publications

Pregnancy with COVID‐19: Management considerations for care of severe and critically ill cases

Pregnancy with COVID‐19: Management considerations for care of severe and critically ill cases

Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia

Predictive factors and prognosis of immune checkpoint inhibitor-related pneumonitis in non-small cell lung cancer patients

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