1977
DOI: 10.1016/0002-9378(77)90096-5
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Androstenedione metabolism in patients with endometrial cancer

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Cited by 38 publications
(7 citation statements)
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“…[5][6][7][8][9][10][11] Potischman et al found that even after controlling for endogenous estrogens, BMI remained a significant risk factor for the development of endometrial cancer. 12 We hypothesized that other obesity-related factors and, in particular, insulin resistance, may contribute to an increased risk for endometrial cancer.…”
mentioning
confidence: 99%
“…[5][6][7][8][9][10][11] Potischman et al found that even after controlling for endogenous estrogens, BMI remained a significant risk factor for the development of endometrial cancer. 12 We hypothesized that other obesity-related factors and, in particular, insulin resistance, may contribute to an increased risk for endometrial cancer.…”
mentioning
confidence: 99%
“…this bleedine was followed with a diaenosis of uterine cancer (Wynder, ~s c 1966). Subsequent rctearch explained the cancer-obesity link when increased levels of unbound cstrogen hormone ( produced in fatty tissue via the A to E, conversion) were mcasured (Benjamin & Deutsch, 1976;Calanog, Sall, Grodin & Southren, 1977;Hausknecht & Gusberg, 1973;Siiteri, 1975). Markedly obese women have been identified as being at five times the risk for devcloping uterine cancer than women of normal weight (Kolata, 1985a).…”
Section: Body Fatmentioning
confidence: 99%
“…Calanog (3) reported that the level of androstenedione and the rate of its conversion to estrone were higher in patients with endometrial cancer than in control postmenopausal subjects. Moreover, testosterone secretion from the ovary is also significantly increased in patients with endometrial cancer (2,4).…”
mentioning
confidence: 99%
“…This may have been because androgen probably reduces ovarian secretion of estrogen by a pituitary feedback mechanism in mature mice with a normal estrous cycle. In women after menopause, ovarian secretion of androgen in place of estrogen increases (8) with the increase in the rate of conversion of androstenedione to estrone (3).…”
mentioning
confidence: 99%