Androgenic and Spermatogenic Activity of Alkylamide‐Rich Ethanol Solution Extract of <i>Anacyclus pyrethrum</i> DC

Sharma, Vikas; Boonen, Jente; Spiegeleer, Bart De; Dixit, Vinod Kumar

doi:10.1002/ptr.4697

Cited by 46 publications

(37 citation statements)

References 23 publications

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“…Administration of alkamide-rich extracts of A. pyrethrum showed improvement in sexual behavior of male rats. With respect to the similar properties observed in L. meyeni the authors suspected the presence of pellitorine (101a) as possible contributor to these effects and hypothesized that alkamides may mimic the action of testosterone or stimulate secretion of testosterone that improves sexual function (Sharma et al , 2013. Similar effects on sexual behavior in male rats were detected in the ethanolic flower extract of Acmella paniculata.…”

Section: Miscellaneous Propertiesmentioning

confidence: 82%

Alkamides: a critical reconsideration of a multifunctional class of unsaturated fatty acid amides

Greger

2015

Phytochem Rev

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Alkamides are natural products formed by connecting straight-chain, mostly unsaturated, aliphatic acids with various amines by an amide linkage. More than 300 derivatives are known from eight plant families consisting of various combinations of 200 acids with 23 amines. Apart from a few saturated derivatives alkamides with unsaturated acid parts are grouped into compounds with purely olefinic patterns and those with olefinic and acetylenic linkages. Derived from C 18 oleic acid the acid parts are modified either by chain elongations to C 28 or by oxidative shortenings to C 4 acid residues. Substrate and regiospecific desaturases and acetylenases are responsible for their characteristic patterns of unsaturation. Amine parts are derived from various amino acids by decarboxylation. Beside the widespread isobutylamines alkamides with six-and five-membered ring amines and those with phenylalanine derived amines are characteristic for the Asteraceae and Piperaceae while benzylamines are restricted to the Brassicaceae. Within the Asteraceae 2-methylbutylamine distinguishes the tribe Heliantheae from Anthemideae characterized by ring amines. Alkamides with elongated olefinic acid parts are mainly found in Piperaceae and Brassicaceae while acetylenic acid parts are typical for Asteraceae. A wide variety of biological activities ranges from the characteristic pungent/ tingling property and high insecticidal toxicity to significant antifungal, antibacterial, antiprotozoal, molluscicidal, cercaricidal, and acaricidal activity. They also act as plant growth-promoting substances. Position and stereochemistry of the double bonds are essential for the different qualities of the pungent taste. Medically alkamides possess anti-inflammatory and analgesic properties and are responsible for immunomodulatory and cannabinomimetic effects.

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Section: Miscellaneous Propertiesmentioning

confidence: 82%

Alkamides: a critical reconsideration of a multifunctional class of unsaturated fatty acid amides

Greger

2015

Phytochem Rev

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“…Additional study further demonstrated the androgenic potential and increased sperm quality (sperm count, motility and viability) along with the fertilising capacity of the semen sample of rats treated with ethanol extract of A. pyrethrum after 28 days of treatment (Sharma et al, 2013). Other effects caused by the ethanol-rich extract include increased weight of the testis and accessory sex glands (prostate, seminal vesicles and epididymis) and spermatogenic activities and reproductive hormone (luteinising hormone and follicle-stimulating hormone) concentrations (Sharma et al, 2013). The aqueous extract of the roots of A. pyrethrum also has the capacity to improve the sexual behaviour of treated rats along with pronounce anabolic and spermatogenic effects.…”

Section: Anac Yclus Pyre Thrummentioning

confidence: 87%

“…The petroleum ether extract of A. pyrethrum was shown to increase the penile erection index, mount and intromission frequency along with decreased mount latency, intromission latency period of male rats (Sharma et al, ). Additional study further demonstrated the androgenic potential and increased sperm quality (sperm count, motility and viability) along with the fertilising capacity of the semen sample of rats treated with ethanol extract of A. pyrethrum after 28 days of treatment (Sharma et al, ). Other effects caused by the ethanol‐rich extract include increased weight of the testis and accessory sex glands (prostate, seminal vesicles and epididymis) and spermatogenic activities and reproductive hormone (luteinising hormone and follicle‐stimulating hormone) concentrations (Sharma et al, ).…”

Section: Anacyclus Pyrethrummentioning

confidence: 95%

Plants in the management of male infertility

Onuah

Singh

2020

Andrologia

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This review attempts to collate existing data and provide the perspectives for future studies on the effects of plants on the male gonads. For many of these medicinal plants such as Lepidium meyenii, Rupus coreanus, Tribulus terrestres, Panax ginseng, Petasites japonicas, Apium graveolens, Eurycoma longifólia, Pedalium murex, Corchorus depressus, Mucuna pruriens, Astragalus membranaceus, Nigella sativa, Crataegus monogyna, Fagara tessmannii, Phaleria macrocarpa, Anacyclus pyrethrum, Cynomorium songaricum and Morinda officinalis, the mechanism of actions of their active principles and crude extracts has been shown in both laboratory animals, in vitro, and human studies, and includes their antioxidant, anti‐inflammatory, spermatogenesis‐inducing, aphrodisiac, smooth muscle relaxing and androgenic properties. Several active chemical leads including glucosinolates, anthocyanins, protodioscin, ginsenosides, sesquiterpenes, phyto‐oestrogens, quassinoids, diosgenin, thymoquinone, proanthocyanidins and bajijiasu isolated from these plants are known to have target effects on the testis, but efforts have been limited in their application at the clinical level. There still appear to be many more extracts of medicinal plants that have not been characterised to determine the phytochemicals unique to them that have target effects on the gonads. Further, collaborative efforts at isolating pro‐drug candidates from medicinal plants for studies at the molecular, cellular and clinical level towards elucidating their mechanisms of action on the testes are therefore warranted in the light of the current male fertility crisis.

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“…Testosterone is the key hormone responsible for regulating spermatogenesis (Dirican and Kalender, 2012), together with maintaining the blood-testis barrier and, supporting the completion of meiosis and spermiation (Mihalik et al, 2015). Importantly, fructose synthesis and secretion is dependent on the secretion of testosterone (Sharma et al, 2013). As noted above, optimal spermatogenesis is a result of the comprehensive effect of hormonal regulation.…”

Section: Discussionmentioning

confidence: 99%

4-Nonylphenol induces disruption of spermatogenesis associated with oxidative stress-related apoptosis by targeting p53-Bcl-2/Bax-Fas/FasL signaling

Duan

Butler

et al. 2016

Environ. Toxicol.

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4-Nonylphenol (NP) is a ubiquitous environmental chemical with estrogenic activity. Our aim was to test the hypothesis that pubertal exposure to NP leads to testicular dysfunction. Herein, 24 7-week-old rats were randomly divided into four groups and treated with NP (0, 25, 50, or 100 mg/kg body weight every 2 days for 20 consecutive days) by intraperitoneal injection. Compared to untreated controls, the parameters of sperm activation rate, curvilinear velocity, average path velocity, and swimming velocity were significantly lower at doses of 100 mg/kg, while sperm morphological abnormalities were higher, indicating functional disruption and reduced fertilization potential. High exposure to NP (100 mg/kg) resulted in disordered arrangement of spermatoblasts and reduction of spermatocytes in seminiferous tubules, while tissues exhibited a marked decline in testicular fructose content and serum FSH, LH, and testosterone levels. Oxidative stress was induced by NP (50 or 100 mg/kg) as evidenced by elevated MDA, decreased SOD and GSH-Px, and inhibited antioxidant gene expression (CAT, GPx, SOD1, and CYP1B1). In addition, NP treatment decreased proportions of Ki-67-positive cells and increased apoptosis in a dose-dependent manner. Rats treated with 100 mg/kg NP exhibited significantly increased mRNA expression of caspase-1, -2, -9, and -11, decreased caspase-8 and PCNA1 mRNA expression, downregulation of Bcl-2/Bax ratios and upregulation of Fas, FasL, and p53 at the protein and mRNA levels. Taken together, NP-induced apoptosis, hormonal deficiencies, and depletion of fructose potentially impairs spermatogenesis and sperm function. p53-independent Fas/FasL-Bax/Bcl-2 pathways may be involved in NP-induced oxidative stress-related apoptosis. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 739-753, 2017.

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Androgenic and Spermatogenic Activity of Alkylamide‐Rich Ethanol Solution Extract of Anacyclus pyrethrum DC

Cited by 46 publications

References 23 publications

Alkamides: a critical reconsideration of a multifunctional class of unsaturated fatty acid amides

Alkamides: a critical reconsideration of a multifunctional class of unsaturated fatty acid amides

Plants in the management of male infertility

4-Nonylphenol induces disruption of spermatogenesis associated with oxidative stress-related apoptosis by targeting p53-Bcl-2/Bax-Fas/FasL signaling

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