Androgen receptor activity in human breast cancer and its relationship with oestrogen and progestogen receptor activity

Androgen receptor expression in male breast carcinoma: lack of clinicopathological association

“…We found no significant association between AR and age, in line with a few reports on FBC (Allegra et al, 1979;Bryan et al, 1984;Miller et al, 1985), nor did we find any association with tumour size or lymph node status, in accordance with similar results on FBCs (Allegra et al, 1979;Miller et al, 1985;Langer et al, 1990). A trend towards association (P = 0.08) was observed for histological grade: 42.8% G1 or 2 cases, but only 8.3% G3 were AR positive, in agreement with studies on FBCs showing that hormone receptors are expressed at higher rates in well-differentiated tumours (Millis, 1980;Walker et al, 1988).…”

“…The reliability of the method is also supported by the association between AR and ER (chi-squared 15.19, P = 0.0001) or by the linear relationship between AR and ER scores (r 0.51, P < 0.001) found in the present series. These results are in accordance with most studies showing association between AR and ER in FBCs (Allegra et al, 1979;Miller et al, 1985;Soreide et al, 1992;Isola, 1993) or MBCs (Pacheco et al, 1986). …”

Androgen receptor expression in male breast carcinoma: lack of clinicopathological association

“…We found no significant association between AR and age, in line with a few reports on FBC (Allegra et al, 1979;Bryan et al, 1984;Miller et al, 1985), nor did we find any association with tumour size or lymph node status, in accordance with similar results on FBCs (Allegra et al, 1979;Miller et al, 1985;Langer et al, 1990). A trend towards association (P = 0.08) was observed for histological grade: 42.8% G1 or 2 cases, but only 8.3% G3 were AR positive, in agreement with studies on FBCs showing that hormone receptors are expressed at higher rates in well-differentiated tumours (Millis, 1980;Walker et al, 1988).…”

“…The reliability of the method is also supported by the association between AR and ER (chi-squared 15.19, P = 0.0001) or by the linear relationship between AR and ER scores (r 0.51, P < 0.001) found in the present series. These results are in accordance with most studies showing association between AR and ER in FBCs (Allegra et al, 1979;Miller et al, 1985;Soreide et al, 1992;Isola, 1993) or MBCs (Pacheco et al, 1986). …”

Androgen, estrogen, and progesterone receptor levels in malignant and benign breast tumors: A multivariate analysis approach

“…It is possible, as suggested by Perez and Coombes (1983, that the interaction between estrogen and ER is the common denominator underlying the action of most hormones, including androgens. Frequency of PR positivity paralleling that of AR positivity has been recently described for breast carcinomas (Miller et al, 1985). Our results confirm this finding.…”

Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer

“…AR expression was shown in several previous studies to be associated with ER and PgR positivity of breast carcinoma tissue [3,11,14,15,18]. The frequent coexpression of AR, ER, and PgR could also be an explanation for the advantage in SAR for patients with AR-expressing tumours, as observed in the present study.…”

Androgen receptor expression in male breast carcinoma: lack of clinicopathological association

“…We found no significant association between AR and age, in line with a few reports on FBC (Allegra et al, 1979;Bryan et al, 1984;Miller et al, 1985), nor did we find any association with tumour size or lymph node status, in accordance with similar results on FBCs (Allegra et al, 1979;Miller et al, 1985;Langer et al, 1990). A trend towards association (P = 0.08) was observed for histological grade: 42.8% G1 or 2 cases, but only 8.3% G3 were AR positive, in agreement with studies on FBCs showing that hormone receptors are expressed at higher rates in well-differentiated tumours (Millis, 1980;Walker et al, 1988).…”

“…The reliability of the method is also supported by the association between AR and ER (chi-squared 15.19, P = 0.0001) or by the linear relationship between AR and ER scores (r 0.51, P < 0.001) found in the present series. These results are in accordance with most studies showing association between AR and ER in FBCs (Allegra et al, 1979;Miller et al, 1985;Soreide et al, 1992;Isola, 1993) or MBCs (Pacheco et al, 1986). …”

Androgen, estrogen, and progesterone receptor levels in malignant and benign breast tumors: A multivariate analysis approach

“…It is possible, as suggested by Perez and Coombes (1983, that the interaction between estrogen and ER is the common denominator underlying the action of most hormones, including androgens. Frequency of PR positivity paralleling that of AR positivity has been recently described for breast carcinomas (Miller et al, 1985). Our results confirm this finding.…”

Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer

“…AR expression was shown in several previous studies to be associated with ER and PgR positivity of breast carcinoma tissue [3,11,14,15,18]. The frequent coexpression of AR, ER, and PgR could also be an explanation for the advantage in SAR for patients with AR-expressing tumours, as observed in the present study.…”

Androgen receptor expression in male breast carcinoma: lack of clinicopathological association

“…We found no significant association between AR and age, in line with a few reports on FBC (Allegra et al, 1979;Bryan et al, 1984;Miller et al, 1985), nor did we find any association with tumour size or lymph node status, in accordance with similar results on FBCs (Allegra et al, 1979;Miller et al, 1985;Langer et al, 1990). A trend towards association (P = 0.08) was observed for histological grade: 42.8% G1 or 2 cases, but only 8.3% G3 were AR positive, in agreement with studies on FBCs showing that hormone receptors are expressed at higher rates in well-differentiated tumours (Millis, 1980;Walker et al, 1988).…”

“…The reliability of the method is also supported by the association between AR and ER (chi-squared 15.19, P = 0.0001) or by the linear relationship between AR and ER scores (r 0.51, P < 0.001) found in the present series. These results are in accordance with most studies showing association between AR and ER in FBCs (Allegra et al, 1979;Miller et al, 1985;Soreide et al, 1992;Isola, 1993) or MBCs (Pacheco et al, 1986). …”

Androgen, estrogen, and progesterone receptor levels in malignant and benign breast tumors: A multivariate analysis approach

“…It is possible, as suggested by Perez and Coombes (1983, that the interaction between estrogen and ER is the common denominator underlying the action of most hormones, including androgens. Frequency of PR positivity paralleling that of AR positivity has been recently described for breast carcinomas (Miller et al, 1985). Our results confirm this finding.…”

Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer

“…AR expression was shown in several previous studies to be associated with ER and PgR positivity of breast carcinoma tissue [3,11,14,15,18]. The frequent coexpression of AR, ER, and PgR could also be an explanation for the advantage in SAR for patients with AR-expressing tumours, as observed in the present study.…”