Androgen deprivation therapy and cardiac function: effects of endurance training

Hydock, David S.; Wonders, Karen Y.; Schneider, Carole M.; Hayward, Reid

doi:10.1038/sj.pcan.4500890

Cited by 11 publications

(12 citation statements)

References 33 publications

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“…LV homogenates were analyzed for MHC isoform expression according to the techniques described by Talmadge and Roy (71) and described previously by our group (8,29). Approximately 100 mg of ventricular tissue was minced in 10 volumes of 4°C homogenizing buffer (mM: 250 sucrose, 100 KCl, 5 EDTA, and 20 Tris-base, pH 6.8) and homogenized with a glass tissue grinder.…”

Section: Methodsmentioning

confidence: 99%

“…Thus far, studies have shown a cardioprotective effect of exercise training during hypogonadal conditions (4,44). However, these studies used surgical castration to induce hypogonadism in male and female rats, and, to our knowledge, only one study has explored the effects of motorized treadmill running on cardiac function during chemical gonadectomy in male rats (29) and no studies have examined the effects of exercise on the female heart during chemical gonadectomy. Therefore, the second purpose of this investigation was to investigate the effects of voluntary wheel running activity on cardiac function in adult male and female rats receiving Zoladex.…”

mentioning

confidence: 92%

“…In addition, surgical gonadectomy-induced cardiac dysfunction has been shown to be associated with a shift in cardiac myosin heavy chain (MHC) isoform distribution from the fast ATPase activity ␣-isoform to the slow ATPase activity ␤-isoform (4,49,60). With the exception of one report (29), minimal work has been done investigating the effects of chemical gonadectomy on cardiac function and cardiac MHC in the male or female heart. Therefore, the first purpose of this investigation was to determine the effects of chemical gonadectomy with Zoladex on cardiac function in adult male and female rats.…”

mentioning

confidence: 97%

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Effects of voluntary wheel running on cardiac function and myosin heavy chain in chemically gonadectomized rats

Hydock

Lien²,

Schneider³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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Reducing testosterone and estrogen levels with a luteinizing hormone-releasing hormone agonist such as Zoladex (i.e., chemical gonadectomy) is a common treatment for many prostate and breast cancer patients, respectively. There are reports of surgical gonadectomy inducing cardiac dysfunction, and exercise has been shown to be cardioprotective under these circumstances. Minimal research has been done investigating the effects of chemical gonadectomy and increased physical activity on cardiac function. The purpose of this investigation was to examine the effects of chemical gonadectomy and physical activity on cardiac function. Male (M) and female (F) Sprague-Dawley rats received either Zoladex treatment (Zol) that suppressed gonadal function for 8 wk or control implants (Con) and either were allowed unlimited access to voluntary running wheels (WR) or remained sedentary (Sed) throughout the treatment period. In vivo and ex vivo left ventricle (LV) function were then assessed, and myosin heavy chain (MHC) expression was analyzed to help explain LV functional differences. Hearts from M Sed+Zol exhibited significantly lower aortic blood flow velocity, developed pressure, and maximal rate of pressure development and higher beta-MHC expression than M Sed+Con. Hearts from F Sed+Zol exhibited significantly lower LV wall thicknesses, fractional shortening, and developed pressure and higher beta-MHC expression than F Sed+Con. This cardiac dysfunction was not evident in hearts from M or F WR+Zol, and this was associated with a preservation of the MHC isoform distribution. Thus an 8-wk chemical gonadectomy with Zoladex promoted cardiac dysfunction in male and female rats, and voluntary wheel running protected against this cardiac dysfunction.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 92%

mentioning

confidence: 97%

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Effects of voluntary wheel running on cardiac function and myosin heavy chain in chemically gonadectomized rats

Hydock

Lien²,

Schneider³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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“…Our laboratory 21 investigated potential cardiovascular benefits of exercise training in an animal model following androgen deprivation therapy. We found that exercise training protected against cardiac dysfunction by preserving the distribution of cardiac myosin heavy chain distribution.…”

Section: Discussionmentioning

confidence: 99%

Exercise Training Manages Cardiopulmonary Function and Fatigue During and Following Cancer Treatment in Male Cancer Survivors

et al. 2007

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This investigation determined the cardiopulmonary function and fatigue alterations in male cancer survivors during treatment as well as following treatment utilizing similar exercise assessment protocols and individualized, prescriptive exercise interventions. The study included 45 male cancer survivors that were referred by local oncologists. Following a comprehensive screening and physical examination, cardiovascular endurance, pulmonary function, and fatigue were assessed leading to the development of 12-week individualized exercise prescriptions and exercise interventions. The cancer survivors were divided into during treatment (DTm) and following treatment (FTm) groups. Repeated-measures analysis of variance and analyses of covariance were used to compare pre-versus postintervention and between groups. Cardiopulmonary function was maintained in the DTm, whereas the FTm showed significant reductions in resting heart rate (P < < .05) with concurrent increases in predicted VO 2 max and time on treadmill (P < < .05) postexercise intervention. Fatigue levels did not increase in the DTm group, whereas the FTm group showed significant reductions in behavioral fatigue, affective fatigue, sensory fatigue, cognitive/mood fatigue, and total fatigue (P < < .05) after the exercise intervention. The results of the current study suggest that moderate intensity, individualized, prescriptive exercise intervention maintains or improves cardiovascular and pulmonary function with concomitant reductions in fatigue in cancer survivors during and following cancer treatment. Exercise appears to be a safe, efficacious strategy for improving physical fitness in cancer survivors during and following treatment.

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“…[59][60][61] Further, a recent study using an animal model has found that aerobic exercise has the potential to provide a protective effect against cardiac dysfunction during ADT. 62 Thus, aerobic and resistance exercise may be an effective method to minimize or overcome ADT cardiovascular-related toxicities. 63 Although it has long been known that physical exercise is an essential lifestyle contributor to significantly reduce cardiovascular and metabolic diseases, efficacy for patients receiving ADT has not been established.…”

Section: Physical Exercise As Potential Countermeasurementioning

confidence: 99%

Cardiovascular and metabolic complications during androgen deprivation: exercise as a potential countermeasure

Galvão

Taaffe

Spry

et al. 2009

Prostate Cancer Prostatic Dis

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Apart from the well-established adverse musculoskeletal and sexual health effects of androgen deprivation therapy (ADT), evidence is accumulating of substantial ADT-related cardiovascular and metabolic complications, which may impact quality of life and overall survival. In this brief review we discuss (1) the incidence of cardiovascular and metabolic complications during/ following ADT from large cohort studies, (2) the increased risk factors for cardiovascular and metabolic disease from cross-sectional and prospective studies and (3) the use of physical exercise as a countermeasure in this new era of ADT-related toxicity. It is clear that exercise has the potential to provide a myriad of benefits to men undergoing ADT that may result in reduced morbidity and mortality, and subsequently improve quality of life.

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Androgen deprivation therapy and cardiac function: effects of endurance training

Cited by 11 publications

References 33 publications

Effects of voluntary wheel running on cardiac function and myosin heavy chain in chemically gonadectomized rats

Effects of voluntary wheel running on cardiac function and myosin heavy chain in chemically gonadectomized rats

Exercise Training Manages Cardiopulmonary Function and Fatigue During and Following Cancer Treatment in Male Cancer Survivors

Cardiovascular and metabolic complications during androgen deprivation: exercise as a potential countermeasure

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