Anatoxin-a: Overview on a harmful cyanobacterial neurotoxin from the environmental scale to the molecular target

Colas, Simon; Marie, Benjamin; Lance, Emilie; Quiblier, Catherine; Tricoire‐Leignel, Hélène; Mattei, César

doi:10.1016/j.envres.2020.110590

Cited by 46 publications

(28 citation statements)

References 127 publications

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“…that had neurotoxin production and resulted in the death of dogs after making contact with these cyanobacterium mats in both France and New Zealand [20,37]. In fact, with regard to ATX, no human fatalities have been reported until now, despite the several deaths reported in wild and domestic animals [38].…”

Section: Anatoxinsmentioning

confidence: 99%

Cyanobacterial Blooms: Current Knowledge and New Perspectives

Moreira

Vasconcelos

Antunes

2022

Earth

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Cyanobacteria are ancient prokaryotes responsible for bloom formation in many freshwater resources worldwide. These dense agglomerations are a result of the rise of nutrient input (N and P) or temperature. The toxin content and illness associated with contact impair human health with repercussions in water quality. Produced by a wide variety of cyanobacteria species, CyanoBlooms are in need of a literature review to achieve a global scenario of its current impacts on freshwater resources aiming at changing behaviors towards CyanoBlooms globally and by making communities more resilient to this recurrent problem. With a global distribution, recent data highlight the impacts of climate change on CyanoBlooms occurrence, namely through the rise of temperature and nutrient input from storms and heavy rainfall. With current worldwide regulations based on the enumeration of the nutrient input of freshwater ecosystems, the increase in field monitoring regarding CyanoBlooms occurrence is demanded since evaluation of this parameter may conceal these massive agglomerations resulting in human health episodes and cyanotoxin outbreaks.

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Section: Anatoxinsmentioning

confidence: 99%

Cyanobacterial Blooms: Current Knowledge and New Perspectives

Moreira

Vasconcelos

Antunes

2022

Earth

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“…Alkaloids are natural compounds containing nitrogen atoms in the aromatic rings, often derivatives from amino acids [157]. Even though most alkaloids are neurotoxins to human beings, some of them have already been approved by the FDA, such as vincristine, atropine and camptothecin derivatives [158][159][160][161]. Trigonelline, a significant constituent of Trigonella foenum-graecum, is reported to be apoptotic and anti-invasive via the downregulation of nuclear factor E2-related factor 2 (Nrf2) dependent proteins and proteasome-dependent proteins [162].…”

Section: Alkaloidsmentioning

confidence: 99%

Progress and Viewpoints of Multifunctional Composite Nanomaterials for Glioblastoma Theranostics

et al. 2022

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The most common malignant tumor of the brain is glioblastoma multiforme (GBM) in adults. Many patients die shortly after diagnosis, and only 6% of patients survive more than 5 years. Moreover, the current average survival of malignant brain tumors is only about 15 months, and the recurrence rate within 2 years is almost 100%. Brain diseases are complicated to treat. The reason for this is that drugs are challenging to deliver to the brain because there is a blood–brain barrier (BBB) protection mechanism in the brain, which only allows water, oxygen, and blood sugar to enter the brain through blood vessels. Other chemicals cannot enter the brain due to their large size or are considered harmful substances. As a result, the efficacy of drugs for treating brain diseases is only about 30%, which cannot satisfy treatment expectations. Therefore, researchers have designed many types of nanoparticles and nanocomposites to fight against the most common malignant tumors in the brain, and they have been successful in animal experiments. This review will discuss the application of various nanocomposites in diagnosing and treating GBM. The topics include (1) the efficient and long-term tracking of brain images (magnetic resonance imaging, MRI, and near-infrared light (NIR)); (2) breaking through BBB for drug delivery; and (3) natural and chemical drugs equipped with nanomaterials. These multifunctional nanoparticles can overcome current difficulties and achieve progressive GBM treatment and diagnosis results.

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“…Benthic blooms are associated with many different toxins, but most commonly with anatoxin-a [10]. Anatoxin-a (ATX) and its congeners, homoanatoxin-a (HTX), dihydroanatoxin-a (dhATX), and dihydrohomoanatoxin-a (dhHTX), are potent agonists of the nicotinic acetylcholine receptors [14]. They interfere with the function of neuromuscular junctions and can cause respiratory arrest in dogs and other vertebrates.…”

Section: Introductionmentioning

confidence: 99%

A singleMicrocoleusspecies causes benthic cyanotoxic blooms worldwide

Junier,

Cailleau,

Fatton

et al. 2023

Preprint

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In the last ten years, blooms of benthic cyanobacteria producing derivatives of the potent neurotoxin anatoxin-a have been repeatedly reported in rivers of temperate regions all over the world. For three series of events, in New Zealand, the USA, and Canada, a cohesive cluster of Microcoleus strains was found to be responsible for the toxin synthesis. Here, we document a similar toxigenic event that occurred at the mouth of the river Areuse in the lake of Neuchatel (Switzerland) and caused the death of several dogs. Using 16S RNA-based community analysis, we show that benthic communities in the river are dominated by Oscillatoriales and especially by the Microcoleus genus. We correlate the detection of one specific sequence variant with the presence of anatoxin-a derivatives and use metagenomics to assemble a complete circular genome of the strain of interest. The strain is distinct from the ones isolated in New Zealand, the USA, and Canada, but belongs to the same species (>94% average nucleotide identity); it shares significant genomic traits with them, in particular a relatively small genome and incomplete vitamin biosynthetic pathways. Overall, our results suggest that the major anatoxin-a-associated benthic proliferations worldwide can be traced back to a single ubiquitous Microcoleus species rather than to a diversity of cyanobacterial lineages. We recommend that this species be monitored internationally and studied in detail in order to help predict and mitigate similar cyanotoxic events.

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Anatoxin-a: Overview on a harmful cyanobacterial neurotoxin from the environmental scale to the molecular target

Cited by 46 publications

References 127 publications

Cyanobacterial Blooms: Current Knowledge and New Perspectives

Cyanobacterial Blooms: Current Knowledge and New Perspectives

Progress and Viewpoints of Multifunctional Composite Nanomaterials for Glioblastoma Theranostics

A singleMicrocoleusspecies causes benthic cyanotoxic blooms worldwide

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