Anatomy of the Skin and the Pathogenesis of Nonmelanoma Skin Cancer

Losquadro, William D.

doi:10.1016/j.fsc.2017.03.001

Cited by 102 publications

(90 citation statements)

References 4 publications

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“…The number of people with NMSC increased from 2.4 million to 3.3 million from 2006 to 2012 in the USA [ 5 ]. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin make up 99% of all NMSC, with BCC being 3 to 5 times more common than SCC [ 1 , 4 , 5 , 6 , 7 ]. Other much less common forms of NMSC include: Merkel cell carcinoma (MCC), primary cutaneous B-cell lymphoma, Kaposi sarcoma, carcinosarcoma, and dermatofibrosarcoma [ 6 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin make up 99% of all NMSC, with BCC being 3 to 5 times more common than SCC [ 1 , 4 , 5 , 6 , 7 ]. Other much less common forms of NMSC include: Merkel cell carcinoma (MCC), primary cutaneous B-cell lymphoma, Kaposi sarcoma, carcinosarcoma, and dermatofibrosarcoma [ 6 , 8 ]. Although NMSCs are generally considered to be curable, they pose a vast problem for healthcare worldwide due to rising incidence [ 1 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Updates on the Management of Non-Melanoma Skin Cancer (NMSC)

et al. 2017

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Non-melanoma skin cancers (NMSCs) are the most common malignancy worldwide, of which 99% are basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of skin. NMSCs are generally considered a curable diseases, yet they currently pose an increasing global healthcare problem due to rising incidence. This has led to a shift in emphasis on prevention of NMSCs with development of various skin cancer prevention programs worldwide. This article aims to summarize the most recent changes and advances made in NMSC management with a focus on prevention, screening, diagnosis, and staging.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Updates on the Management of Non-Melanoma Skin Cancer (NMSC)

et al. 2017

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“…The dermis is derived from three different layers: the facial dermis and cervical dermis derive from the neural crest; limb dermis and torso dermis originate from the lateral plate mesoderm; and the dermis of the back evolves from the paraxial mesoderm [ 29 ].…”

Section: Comparison Of Tissue Structure and Composition Of Tendon mentioning

confidence: 99%

Rebuilding Tendons: A Concise Review on the Potential of Dermal Fibroblasts

Chu

Pfeifer

et al. 2020

Cells

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Tendons are vital to joint movement by connecting muscles to bones. Along with an increasing incidence of tendon injuries, tendon disorders can burden the quality of life of patients or the career of athletes. Current treatments involve surgical reconstruction and conservative therapy. Especially in the elderly population, tendon recovery requires lengthy periods and it may result in unsatisfactory outcome. Cell-mediated tendon engineering is a rapidly progressing experimental and pre-clinical field, which holds great potential for an alternative approach to established medical treatments. The selection of an appropriate cell source is critical and remains under investigation. Dermal fibroblasts exhibit multiple similarities to tendon cells, suggesting they may be a promising cell source for tendon engineering. Hence, the purpose of this review article was in brief, to compare tendon to dermis tissues, and summarize in vitro studies on tenogenic differentiation of dermal fibroblasts. Furthermore, analysis of an open source Gene Expression Omnibus (GEO) data repository was carried out, revealing great overlap in the molecular profiles of both cell types. Lastly, a summary of in vivo studies employing dermal fibroblasts in tendon repair as well as pilot clinical studies in this area is included. Altogether, dermal fibroblasts hold therapeutic potential and are attractive cells for rebuilding injured tendons.

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“…In Caucasians the risk for skin cancer exceeds 20% and increases with age [6]. Basal cell carcinoma and squamous cell carcinoma (SCC) constitute the total of 99% of all NMSC cases, whereby BCC is diagnosed 3-5 times more often than SCC [1,5,7].…”

Section: Wprowadzeniementioning

confidence: 99%

“…U osób rasy kaukaskiej ryzyko zachorowania na raka skóry przekracza 20% i wzrasta z wiekiem [6]. Rak podstawnokomórkowy i rak kolczystokomórkowy (squamous cell carcinoma -SCC) stanowią łącznie nawet 99% wszystkich NMSC, przy czym BCC jest rozpoznawany 3-5 razy częściej niż SCC [1,5,7].…”

Section: Aetiology and Risk Factorsunclassified

Basal cell carcinoma. Diagnostic and therapeutic recommendations of Polish Dermatological Society

Lesiak¹,

Czuwara²,

Kamińska‐Winciorek³

et al. 2019

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Incidence of skin cancers is constantly increasing, what constitutes a significant epidemiologic problem of modern medicine. Basal cell carcinoma is the most common neoplasm affecting Caucasians. Histopathological examination is a gold standard that allows for diagnosing skin cancers. The presented recommendations discuss clinical and pathomorphological sub-types of basal cell carcinoma, their dermoscopic features, stage assessment, and methods for treatment as well as prevention of recurrence of this cancer. Surgical excision of the lesion is a basic and preferred therapeutic option. Other non-surgical options show lower treatment efficacy, and thus, should be considered in cases of cancers with low risk of recurrence, when a surgery is contraindicated or impossible.

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Anatomy of the Skin and the Pathogenesis of Nonmelanoma Skin Cancer

Cited by 102 publications

References 4 publications

Updates on the Management of Non-Melanoma Skin Cancer (NMSC)

Updates on the Management of Non-Melanoma Skin Cancer (NMSC)

Rebuilding Tendons: A Concise Review on the Potential of Dermal Fibroblasts

Basal cell carcinoma. Diagnostic and therapeutic recommendations of Polish Dermatological Society

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